CAS 64544-07-6

Cefuroxime axetil

Description:

Cefuroxime axetil is a broad-spectrum cephalosporin antibiotic used primarily to treat bacterial infections. It is a prodrug, meaning it is converted into its active form, cefuroxime, after administration. This compound is characterized by its ability to inhibit bacterial cell wall synthesis, making it effective against a variety of Gram-positive and Gram-negative bacteria. Cefuroxime axetil is typically administered orally and is known for its good bioavailability compared to other cephalosporins. The substance is generally stable in acidic environments, which enhances its absorption in the gastrointestinal tract. It is often used to treat respiratory tract infections, skin infections, and urinary tract infections. Common side effects may include gastrointestinal disturbances, allergic reactions, and, in rare cases, more severe hypersensitivity reactions. As with all antibiotics, it is crucial to use cefuroxime axetil judiciously to prevent the development of antibiotic resistance.

Formula: C₂₀H₂₂N₄O₁₀S

InChI: InChI=1S/C20H22N4O10S/c1-9(25)33-10(2)34-19(28)15-11(7-32-20(21)29)8-35-18-14(17(27)24(15)18)22-16(26)13(23-30-3)12-5-4-6-31-12/h4-6,10,14,18H,7-8H2,1-3H3,(H2,21,29)(H,22,26)/b23-13-/t10?,14-,18-/m1/s1

InChI key: InChIKey=KEJCWVGMRLCZQQ-YJBYXUATSA-N

SMILES: C(OC(OC(C)=O)C)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC)/C3=CC=CO3)=O)C2=O)(SCC1COC(N)=O)[H]

Synonyms:

• 1-(acetyloxy)ethyl (6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2E)-2-furan-2-yl-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-furanyl(methoxyimino)a cetyl)-amino)-8-oxo-, 1-(acetyloxy)ethyl ester, (6R-(6alpha,7beta(Z)))-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-furanyl)-2-(methoxyimino)acetyl]amino]-8-oxo-, 1-(acetyloxy)ethyl ester, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-furanyl(methoxyimino)acetyl]amino]-8-oxo-, 1-(acetyloxy)ethyl ester, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-7-[[2-furanyl(methoxyimino)acetyl]amino]-8-oxo-, 1-(acetyloxy)ethyl ester, [6R-[6α,7β(Z)]]-
• Altacef
• Axoril
• Bioracef
• Bioxime
• Cci 15641
• Cefaks
• Cefazine
• Ceftin
• Cefurax
• Cefuroxime 1-Acetoxymethyl Ester
• Cefuroxime 1-acetoxyethyl ester
• Cefuroxine 1-acetoxyethyl ester
• Cepazine
• Elobact
• Forcef
• Kefurox
• Oraxim
• Ximos
• Xorimax
• Zinacef
• Zinat
• Zinnat

Cefuroxime axetil

CAS: 64544-07-6

Cefuroxime axetil

Formula: C₂₀H₂₂N₄O₁₀S

Purity: 98.2%

Color and Shape: Off White Solid

Molecular weight: 510.10566

Ref: 47-502

CEFUROXIME AXETIL CRS

CAS: 64544-07-6

CEFUROXIME AXETIL CRS

Ref: 41-C0694990

Cefuroxime Axetil

CAS: 64544-07-6

Antibiotics nesoi

Formula: C₂₀H₂₂N₄O₁₀S

Color and Shape: White Off-White Powder

Molecular weight: 510.10566

Ref: 45-1098220

Cefuroxime axetil

CAS: 64544-07-6

Cefuroxime axetil (Zinnat) is a second generation oral cephalosporin antibiotic.

Formula: C₂₀H₂₂N₄O₁₀S

Purity: 99.47% - 99.61%

Color and Shape: White To Off-White Powder

Molecular weight: 510.47

Ref: TM-T1227

Cefuroxime axetil

CAS: 64544-07-6

Cefuroxime axetil

Purity: ≥98%

Molecular weight: 510.47g/mol

Ref: 54-BUP13736

Cefuroxime axetil

CAS: 64544-07-6

Formula: C₁₆H₁₆N₄O₈S

Purity: ≥ 96.0% (sum of diastereoisomers)

Color and Shape: White to almost white powder

Molecular weight: 424.39

Ref: 7W-GP5640

Cefuroxime Axetil

CAS: 64544-07-6

Formula: C₂₀H₂₂N₄O₁₀S

Purity: >95.0%(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 510.47

Ref: 3B-C3750

Cefuroxime Axetil

CAS: 64544-07-6

Color and Shape: Neat

Ref: 86-MM0339.00

Cefuroxime Axetil

CAS: 64544-07-6

Formula: C₂₀H₂₂N₄O₁₀S

Molecular weight: 510.47

Ref: 4Z-C-445059

Cefuroxime Axetil

CAS: 64544-07-6

Applications It is the 1-(acetyloxy) ethyl ester of Cefuroxime (C248060), an injectable second generation cephalosporin with an excellent antibacterial activity. This ester has a broader spectrum of activity than cephalexin (first-generation) and is widely used to treat respiratory tract infections. Antibacterial.
References Nguyen, N., et al.: Pharm. Res., 8, 893 (1991), Stoeckel, K., et al.: Antimicrob. Agents Chemother., 42, 2602 (1998), Scott, L., et al.: Drugs, 61, 1455 (2001), Bulitta, J. B., et al.: Antimicrob. Agents Chemother., 53, 3462 (2009);

Formula: C₂₀H₂₂N₄O₁₀S

Color and Shape: White To Light Yellow

Molecular weight: 510.47

Ref: TR-C248065

Cefuroxime axetil

CAS: 64544-07-6

Cefuroxime axetil is a prodrug of cefuroxime with action on bacterial cell wall synthesis and is used for treating bacterial infections like sinusitis, bronchitis, and gonorrhea.

Formula: C₂₀H₂₂N₄O₁₀S

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 510.48 g/mol

Ref: 3D-AC19882

Cefuroxime Axetil-d3

Controlled Product

CAS: 64544-07-6

Formula: C₂₀D₃H₁₉N₄O₁₀S

Color and Shape: Neat

Molecular weight: 513.493

Ref: TR-C248067