CAS 64567-60-8

2-(2,6-dioxopiperidin-3-yl)-5-hydroxy-1H-isoindole-1,3(2H)-dione

Description:

2-(2,6-Dioxopiperidin-3-yl)-5-hydroxy-1H-isoindole-1,3(2H)-dione, with the CAS number 64567-60-8, is a chemical compound that features a complex structure incorporating both piperidine and isoindole moieties. This compound is characterized by the presence of multiple functional groups, including carbonyls and hydroxyls, which contribute to its potential reactivity and biological activity. The dioxopiperidine portion suggests that it may participate in various chemical reactions, such as nucleophilic attacks or cyclization processes. The hydroxy group on the isoindole ring enhances its solubility in polar solvents and may influence its interaction with biological targets. This compound may exhibit pharmacological properties, making it of interest in medicinal chemistry. Its structural features suggest potential applications in drug development, particularly in the design of compounds targeting specific biological pathways. However, detailed studies on its biological activity, toxicity, and pharmacokinetics would be necessary to fully understand its potential uses and safety profile.

Formula: C₁₃H₁₀N₂O₅

InChI: InChI=1/C13H10N2O5/c16-6-1-2-7-8(5-6)13(20)15(12(7)19)9-3-4-10(17)14-11(9)18/h1-2,5,9,16H,3-4H2,(H,14,17,18)

SMILES: c1cc2c(cc1O)C(=O)N(C1CCC(=NC1=O)O)C2=O

Synonyms:

• 1H-isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-
• Thalidomide-5-OH
• Thalidomide5-HydroxyisoindolineImpurity
• 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione
• 4-Hydroxythalidomide/Thalidomide-5-OH
• ThalidomideImpurity2
• 2-(2,6-DioChemicalbookxo-3-piperidinyl)-5-hydroxy-1H-isoindole-1,3(2H)-dione
• 2-(2,6-Dioxo-3-piperidinyl)-5-hydroxy-1,3-isoindolinedione
• Thalidomide 5-Hydroxyisoindoline Impurity
• Thalidomide Impurity 2
• 2-(2,6-Dioxo-3-piperidinyl)-5-hydroxy-1H-isoindole-1,3(2H)-dione

5-Hydroxythalidomide

CAS: 64567-60-8

Formula: C₁₃H₁₀N₂O₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 274.2289

Ref: IN-DA01EA4C

4-Hydroxy Thalidomide

CAS: 64567-60-8

Formula: C₁₃H₁₀N₂O₅

Color and Shape: Pale Yellow Solid

Molecular weight: 274.24

Ref: 4Z-T-235

2-(2,6-Dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione

CAS: 64567-60-8

2-(2,6-Dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione

Formula: C₁₃H₁₀N₂O₅

Purity: 98%

Color and Shape: white solid

Molecular weight: 274.2289g/mol

Ref: 54-OR62182

Thalidomide-5-OH

CAS: 64567-60-8

Thalidomide-5-OH

Purity: ≥98%

Molecular weight: 274.23g/mol

Ref: 54-BUP18152

2-(2,6-Dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione

CAS: 64567-60-8

Formula: C₁₃H₁₀N₂O₅

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 274.23

Ref: 3B-D6178

Thalidomide-5-OH

CAS: 64567-60-8

Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) is the Thalidomide-based cereblon ligand that used in the recruitment of CRBN

Formula: C₁₃H₁₀N₂O₅

Purity: 98.94%

Color and Shape: Solid

Molecular weight: 274.23

Ref: TM-T9291

4-Hydroxy thalidomide

CAS: 64567-60-8

4-Hydroxy thalidomide is a drug that has a variety of clinical use. It is used in the treatment of leprosy, multiple myeloma and other cancers. 4-Hydroxy thalidomide also shows anti-inflammatory properties and has been shown to inhibit protein synthesis in human liver cells and rat liver microsomes. The drug is an antagonist of hydroxyl group or hydroxy group, which may be due to its ability to inhibit ubiquitin ligases. 4-Hydroxy thalidomide can be metabolized by humans into metabolites that bind to the all-trans retinoic acid receptor, which may lead to fetal bovine syndrome.

Formula: C₁₃H₁₀N₂O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 274.23 g/mol

Ref: 3D-FH46213

2-(2,6-DIOXOPIPERIDIN-3-YL)-5-HYDROXYISOINDOLINE-1,3-DIONE

CAS: 64567-60-8

Purity: 95%

Color and Shape: Solid

Molecular weight: 274.2319946

Ref: 10-F837555

4-Hydroxy Thalidomide

CAS: 64567-60-8

Formula: C₁₃H₁₀N₂O₅

Molecular weight: 274.24

Ref: ST-EA-CP-T144005