CAS 64657-18-7

(-)-1,9-Dideoxyforskolin

Description:

(-)-1,9-Dideoxyforskolin is a chemical compound derived from the plant Coleus forskohlii, known for its potential pharmacological properties. It is a derivative of forskolin, which is a labdane diterpene. This compound is characterized by its unique structural features, including a bicyclic framework and specific functional groups that contribute to its biological activity. (-)-1,9-Dideoxyforskolin has been studied for its ability to activate adenylate cyclase, leading to increased levels of cyclic AMP (cAMP) in cells, which plays a crucial role in various signaling pathways. The compound exhibits potential therapeutic effects, including anti-inflammatory and anti-cancer properties, although further research is needed to fully understand its mechanisms and applications. Additionally, it is important to note that the stereochemistry of the compound influences its biological activity, with the (-) enantiomer being specifically noted for its effects. As with many natural products, the safety and efficacy of (-)-1,9-Dideoxyforskolin in clinical settings require thorough investigation.

Formula: C₂₂H₃₄O₅

InChI: InChI=1/C22H34O5/c1-8-20(5)12-14(24)16-21(6)11-9-10-19(3,4)17(21)15(25)18(26-13(2)23)22(16,7)27-20/h8,15-18,25H,1,9-12H2,2-7H3/t15-,16+,17-,18-,20-,21+,22-/m0/s1

InChI key: InChIKey=ZKZMDXUDDJYAIB-SUCLLAFCSA-N

SMILES: C[C@]12[C@@]([C@]3(C)[C@@]([C@H](O)[C@@H]1OC(C)=O)(C(C)(C)CCC3)[H])(C(=O)C[C@@](C=C)(C)O2)[H]

Synonyms:

• (-)-1,9-Dideoxyforskolin
• (3R,4aS,5S,6S,6aS,10aS,10bR)-5-(Acetyloxy)-3-ethenyldodecahydro-6-hydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
• 1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6-hydroxy-3,4a,7,7,10a-pentamethyl-, (3R,4aS,5S,6S,6aS,10aS,10bR)-
• 1H-Naphtho[2,1-b]pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6-hydroxy-3,4a,7,7,10a-pentamethyl-, [3R-(3α,4aβ,5β,6β,6aα,10aβ,10bα)]-
• 1H-Naphtho(2,1-B)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6-hydroxy-3,4A,7,7,10A-pentamethyl-, (3R-(3alpha,4abeta,5beta,6beta,6aalpha,10abeta,10balpha))-
• DIDEOXYFORSKOLIN, 1,9-
• 7BETA-ACETOXY-8,13-EPOXY-6BETA-HYDROXY-LABD-14-EN-11-ONE
• 7β-acetoxy-6β-hydroxy-8,13-epoxy-labd-14-en-11-one
• FORSKOLIN, 1,9-DIDEOXY ISOLATED FROM COL EUS
• (3R,4aS,5S,6S,6aS,10aS,10bR)-6-hydroxy-3,4a,7,7,10a-pentaMethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chroMen-5-yl acetate
• 7BETA-ACETOXY-6BETA-HYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE
• Dideoxyforskolin
• (3R,6aα,10bβ)-5β-Acetoxy-3α-ethenyldodecahydro-6β-hydroxy-3,4aβ,7,7,10aβ-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
• Dideoxyforskolin from Coleus forskohlii
• Forskolin, 1,9-Dideoxy-, Coleus forskohlii - CAS 64657-18-7 - Calbiochem
• FORSKOLIN, 1,9-DIDEOXY
• 1,9-DIDEOXYFORSKOLIN FROM COLEUSFORSKOHL II
• ddFSK
• (3R,6aα,10bβ)-3,4aβ,7,7,10aβ-Pentamethyl-3α-vinyl-5β-acetoxy-6β-hydroxydodecahydro-1H-naphtho[2,1-b]pyran-1-one
• 9-Dideoxyforskolin

1,9-Dideoxyforskolin

CAS: 64657-18-7

Formula: C₂₂H₃₄O₅

Molecular weight: 378.50

Ref: 7W-GL2615

1,9-Dideoxyforskolin + 1-Deoxyforskolin (1:1 Ratio)

Controlled Product

CAS: 64657-18-7

Applications 1,9-Dideoxyforskolin + 1-Deoxyforskolin (1:1 Ratio) is an impurity from the synthesis of 9-Deoxyforskolin (D239935) from Coleus forskohlii, which is an adenylyl cyclase isoform activator; Antihypertensive.
References Pinto, C., et al.: J. Pharmacol. Exp. Ther., 325, 27-36 (2008); Bhat, S., et al.: J. Med. Chem., 26, 486-492 (1983);

Formula: C₂₂H₃₄O₅

Color and Shape: Neat

Molecular weight: 378.502

Ref: TR-F701810

1,9-Dideoxyforskolin

Controlled Product

CAS: 64657-18-7

Formula: C₂₂H₃₄O₅

Color and Shape: Neat

Molecular weight: 378.502

Ref: TR-D439970

1,9-Dideoxyforskolin

CAS: 64657-18-7

The compound is an inactive analog of forskolin(an adenylyl cyclase activator).

Formula: C₂₂H₃₄O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 378.5

Ref: TM-T22467