CAS 64740-68-7

1',4-Dihydroxy Midazolam

Controlled Product

CAS: 64740-68-7

Applications A metabolite of Midazolam (M343000).
References Soucek, P., et al.: Xenobiotica, 22, 83 (1992), Ghosal, A., et al.: Drug Metab. Dispos., 24, 940 (1996), Kobayashi, K., et al.: Biochem. Pharmacol., 63, 889 (2002),

Formula: C₁₈H₁₃ClFN₃O₂

Color and Shape: Neat

Molecular weight: 357.77

Ref: TR-D453400

1',4-Dihydroxy midazolam

Controlled Product

CAS: 64740-68-7

1',4-Dihydroxy midazolam is a metabolite of diazepam. It is formed by the oxidation of the 1'-hydroxyl group in the benzene ring to an alcohol and a subsequent hydrolysis of the alcohol to a carboxylic acid group. This metabolite has been shown to have low affinity for binding with cytochrome P450 enzymes in vitro and in vivo, which may be due to its high polarity. The 1',4-dihydroxy midazolam is rapidly eliminated from plasma and has a short half-life. The clearance rate for 1',4-dihydroxy midazolam is higher than that for diazepam, suggesting that this metabolite may be responsible for some of the therapeutic effects observed with diazepam treatment.

Formula: C₁₈H₁₃ClFN₃O₂

Purity: Min. 95%

Molecular weight: 357.77 g/mol

Ref: 3D-FD22057

1',4-Dihydroxy Midazolam

CAS: 64740-68-7

Formula: C₁₈H₁₃ClFN₃O₂

Molecular weight: 357.8

Ref: ST-EA-CP-M85018