CAS 64854-64-4

(D-ala2,N-me-phe4,met(O)5-ol)*enkephalin

Description:

(D-ala2,N-me-phe4,met(O)5-ol)*enkephalin, with the CAS number 64854-64-4, is a synthetic peptide that is a modified form of enkephalin, which is a type of endogenous opioid peptide. This compound features specific amino acid substitutions that enhance its stability and potency compared to natural enkephalins. The presence of D-alanine at the second position and N-methylphenylalanine at the fourth position contributes to its resistance to enzymatic degradation, making it more effective in therapeutic applications. Additionally, the methionine sulfoxide modification at the fifth position may influence its binding affinity to opioid receptors. This peptide exhibits analgesic properties and is studied for its potential in pain management and other neurological conditions. Its structure allows it to interact with the central nervous system, mimicking the effects of natural opioids while potentially reducing side effects associated with traditional opioid medications. Overall, this compound represents a significant advancement in peptide design for therapeutic use.

Formula: C₂₉H₄₁N₅O₇S

InChI: InChI=1/C29H41N5O7S/c1-19(32-28(39)24(30)15-21-9-11-23(36)12-10-21)27(38)31-17-26(37)34(2)25(16-20-7-5-4-6-8-20)29(40)33-22(18-35)13-14-42(3)41/h4-12,19,22,24-25,35-36H,13-18,30H2,1-3H3,(H,31,38)(H,32,39)(H,33,40)

SMILES: CC(C(=NCC(=O)N(C)C(Cc1ccccc1)C(=NC(CCS(=O)C)CO)O)O)N=C(C(Cc1ccc(cc1)O)N)O

Synonyms:

• Fk 33-824
• (D-Ala2,MePhe4,Met5(O))enkephalinol
• (D-Ala2,N-methyl-Phe4,Met-(O)5-ol)enkepyhalin
• Brn 3079169
• Damme
• San 33-824
• Sandoz 33-824
• Sandoz FK 33-824
• L-Phenylalaninamide, L-tyrosyl-D-alanylglycyl-N-(1-(hydroxymethyl)-3-(methylsulfinyl)propyl)-N(sup alpha)-methyl-, (1S)-
• L-Phenylalaninamide, L-tyrosyl-D-alanylglycyl-N-(1-(hydroxymethyl)-3-(methylsulfinyl)propyl)-nalpha-methyl-, (1S)-
• tyrosylalanylglycyl-N-[1-hydroxy-4-(methylsulfinyl)butan-2-yl]-Nalpha-methylphenylalaninamide

(D-Ala2,N-Me-Phe4,methionin(O)-ol5)-Enkephalin trifluoroacetate salt

CAS: 64854-64-4

D-Ala2,N-Me-Phe4,methionin(O)-ol5)-Enkephalin trifluoroacetate salt H-Tyr-D-Ala-Gly-N-Me-Phe-methionin(O)-ol trifluoroacetate salt is an analog of the endocannabinoid neurotransmitter, anandamide. It has been shown to be effective in the treatment of autoimmune diseases such as multiple sclerosis and inflammatory bowel disease. D-(3R)-3-[(1S,2R,3R,5R) -3-[2-(2,6 dichlorophenyl)ethenyl] -1H -indole]-1 -butanamine trifluoroacetate salt has been shown to inhibit the replication of a number of viruses including human immunodeficiency virus type 1 (HIV). This drug also inhibits the growth of organisms that are resistant

Formula: C₂₉H₄₁N₅O₇S

Purity: Min. 95%

Molecular weight: 603.73 g/mol

Ref: 3D-FA110298

FK 33-824

CAS: 64854-64-4

FK 33-824, a stable synthetic analog of methionine enkephalin, reversible with naloxone.

Formula: C₂₉H₄₁N₅O₇S

Purity: 98%

Color and Shape: Solid

Molecular weight: 603.73

Ref: TM-T25420