CAS 64907-23-9

7-keto-25-Hydroxycholesterol

Description:

7-Keto-25-Hydroxycholesterol, identified by its CAS number 64907-23-9, is a derivative of cholesterol and belongs to the class of oxysterols, which are oxygenated derivatives of cholesterol. This compound is characterized by the presence of a keto group at the 7-position and a hydroxyl group at the 25-position of the cholesterol backbone. It is a biologically active molecule that plays a role in various physiological processes, including cholesterol metabolism and regulation of lipid homeostasis. 7-Keto-25-Hydroxycholesterol has been studied for its potential effects on inflammation and immune responses, as well as its involvement in signaling pathways related to cell growth and differentiation. The compound is typically found in biological systems and can be synthesized through enzymatic pathways involving cholesterol. Its unique structure contributes to its biological activity, making it a subject of interest in research related to cardiovascular health and metabolic disorders.

Formula: C₂₇H₄₄O₃

InChI: InChI=1S/C27H44O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h16-17,19-22,24,28,30H,6-15H2,1-5H3/t17-,19+,20-,21+,22+,24+,26+,27-/m1/s1

InChI key: InChIKey=NQBVGGWSAXBLBE-BYJKJZODSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3=O)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CCCC(C)(C)O)C)[H])[H]

Synonyms:

• 25-Hydroxy-7-ketocholesterol
• (3β)-3,25-Dihydroxycholest-5-en-7-one
• Cholest-5-en-7-one, 3,25-dihydroxy-, (3β)-
• 7-keto-25-Hydroxycholesterol
• 3β,25-Dihydroxycholest-5-en-7-one

(3b)-3,25-Dihydroxycholest-5-en-7-one

Controlled Product

CAS: 64907-23-9

Applications (3β)-3,25-Dihydroxycholest-5-en-7-one is a useful synthetic intermediate in the synthesis of 3β,7α,25-Trihydroxycholest-5-ene (T795075); a potent agonist of GPR183 that induces specific activation of the receptor.
References Antunes, L., et al.: Antimicrob. Agents. Chemtherap., 55, 1494 (2011); Schwarz, M., et al.: J. Cin. Invest., 106, 1175 (2000); Zhang, J., et al.: BIochem. J., 322, 175 (1997)

Formula: C₂₇H₄₄O₃

Color and Shape: Neat

Molecular weight: 416.64

Ref: TR-D452805

(3β)-3,25-Dihydroxycholest-5-en-7-one

Controlled Product

CAS: 64907-23-9

Please enquire for more information about (3β)-3,25-Dihydroxycholest-5-en-7-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₂₇H₄₄O₃

Purity: Min. 95%

Molecular weight: 416.6 g/mol

Ref: 3D-PCA90723

7-keto-25-hydroxy Cholesterol

CAS: 64907-23-9

7-Keto-25-hydroxy Cholesterol, an oxysterol and proposed metabolite of 7-keto cholesterol and 7-dehydro cholesterol, binds to and activates Smoothened (Smo) at the conserved extracellular cysteine-rich domain (CRD) in a reporter assay. Additionally, it enhances the number of EGF high affinity binding sites in normal rat kidney (NRK) cells.

Formula: C₂₇H₄₄O₃

Color and Shape: Solid

Molecular weight: 416.646

Ref: TM-T85249