CAS 64925-80-0

phomopsin A

Description:

Phomopsin A is a mycotoxin produced by certain species of fungi, particularly those in the genus Phomopsis. It is characterized by its complex molecular structure, which includes multiple functional groups that contribute to its biological activity. Phomopsin A exhibits potent cytotoxic properties, making it a subject of interest in toxicology and pharmacology. It is known to inhibit protein synthesis, which can lead to cell death in susceptible organisms. This compound is often studied for its implications in food safety, particularly in relation to contaminated crops, as it poses risks to both human and animal health. Additionally, Phomopsin A's stability under various environmental conditions can influence its persistence in contaminated substrates. Due to its toxic nature, research continues to explore methods for detection, mitigation, and understanding the mechanisms of its toxicity. Overall, Phomopsin A serves as a significant example of the impact of fungal metabolites on health and agriculture.

Formula: C₃₆H₄₅ClN₆O₁₂

InChI: InChI=1/C36H45ClN6O12/c1-8-17(5)25-32(51)38-20(15-23(45)46)34(53)42(7)26(27(47)18-13-19(37)28(48)22(44)14-18)33(52)39-24(16(3)4)31(50)41-29(36(6,55)9-2)35(54)43-12-10-11-21(43)30(49)40-25/h10-11,13-15,21,24,26-27,29,44,47-48,55H,3,8-9,12H2,1-2,4-7H3,(H,38,51)(H,39,52)(H,40,49)(H,41,50)(H,45,46)/b20-15-,25-17-

SMILES: CC/C(=C\1/C(=N/C(=C\C(=O)O)/C(=O)N(C)C(C(c2cc(c(c(c2)O)O)Cl)O)C(=NC(C(=C)C)C(=NC(C(=O)N2CC=CC2C(=N1)O)C(C)(CC)O)O)O)O)/C

Synonyms:

• (2Z)-[(3Z)-9-[(3-chloro-4,5-dihydroxyphenyl)(hydroxy)methyl]-15-(1-hydroxy-1-methylpropyl)-8-methyl-12-(1-methylethenyl)-3-(1-methylpropylidene)-1,4,7,10,13,16-hexaoxo-2,3,4,5,7,8,9,10,11,12,13,14,15,16,18,20a-hexadecahydropyrrolo[1,2-a][1,4,7,10,13,16]hexaazacyclooctadecin-6(1H)-ylidene]ethanoic acid
• Phomopsin A
• phomopsin
• Phomopsin A, 98%, from Phomopsis leptostromiformis
• PMSA
• phomopsin a from phomopsis leptostromiformis
• Aspartic acid, (βS)-3-chloro-β,5-dihydroxy-N-methyl-L-tyrosyl-3,4-didehydro-L-valyl-3-hydroxy-L-isoleucyl-3,4-didehydro-L-prolyl-(2E)-2,3-didehydroisoleucyl-2,3-didehydro-, cyclic (15→3)-ether, (2E)-

Phomopsin A

CAS: 64925-80-0

Phomopsin A

Formula: C₃₆H₄₅ClN₆O₁₂

Purity: By hplc: 96.6% (Typical Value in Batch COA)

Color and Shape: white powder

Molecular weight: 789.23g/mol

Ref: 54-BIA4325

Phomopsin A

CAS: 64925-80-0

Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis.

Formula: C₃₆H₄₅ClN₆O₁₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 789.23

Ref: TM-T12448

Phomopsin A

CAS: 64925-80-0

Formula: C₃₆H₄₅ClN₆O₁₂

Molecular weight: 789.24

Ref: 4Z-P-447003

Phomopsin A

CAS: 64925-80-0

Ref: 7W-GW8143

Phomopsin A

CAS: 64925-80-0

Applications Phomopsin A is a potent microtubule inhibitor.
References Lacey, E., et al.: Biochem. Pharmacol., 36, 2133-2138 (1987); Ludueña, R.F., et al.: Biochem. Pharmacol., 39, 1603-1608 (1990); Chaudhuri, A.R., et al.: J. Protein Chem., 16, 99-105 (1997);

Formula: C₃₆H₄₅ClN₆O₁₂

Color and Shape: Neat

Molecular weight: 789.23

Ref: TR-P380005