CAS 6494-19-5

3-Methyl-6-nitro-1H-indazole

Description:

3-Methyl-6-nitro-1H-indazole is an organic compound characterized by its indazole structure, which consists of a five-membered ring fused to a six-membered benzene ring. The presence of a methyl group at the 3-position and a nitro group at the 6-position contributes to its unique chemical properties. This compound is typically a yellow to orange crystalline solid and is known for its potential applications in medicinal chemistry and as a building block in organic synthesis. It exhibits moderate solubility in organic solvents, and its reactivity can be influenced by the electron-withdrawing nitro group, which can participate in various chemical reactions, including nucleophilic substitutions and reductions. Additionally, 3-Methyl-6-nitro-1H-indazole may exhibit biological activity, making it of interest in pharmacological research. Safety data should be consulted for handling, as nitro compounds can be sensitive and may pose health risks. Overall, this compound serves as an important example of functionalized heterocycles in organic chemistry.

Formula: C₈H₇N₃O₂

InChI: InChI=1S/C8H7N3O2/c1-5-7-3-2-6(11(12)13)4-8(7)10-9-5/h2-4H,1H3,(H,9,10)

InChI key: InChIKey=FUNWSYKLFDLUIZ-UHFFFAOYSA-N

SMILES: CC=1C=2C(=CC(N(=O)=O)=CC2)NN1

Synonyms:

• 1H-Indazole, 3-methyl-6-nitro-
• 3-Methyl-6-Nifro-1H-Indazole
• 3-Methyl-6-Nitro-1H-Indozole
• 3-Methyl-6-nitro-1H-indazole
• 3-methyl-6-nitro-3H-indazole
• 6-Nitro-3-methylindazole
• 3-Methyl-6-nitroindazole

3-Methyl-6-nitroindazole

CAS: 6494-19-5

Formula: C₈H₇N₃O₂

Purity: >98.0%(GC)

Color and Shape: Light yellow to Brown powder to crystal

Molecular weight: 177.16

Ref: 3B-M2358

3-Methyl-6-nitro-1H-indazole

CAS: 6494-19-5

Formula: C₈H₇N₃O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 177.1601

Ref: IN-DA0033R9

3-Methyl-6-nitro-1h-indazole

CAS: 6494-19-5

3-Methyl-6-nitro-1h-indazole

Formula: C₈H₇N₃O₂

Purity: 99%

Color and Shape: gold to faint tan. wooly powder

Molecular weight: 177.16g/mol

Ref: 54-OR350252

3-Methyl-6-nitro-1H-indazole

CAS: 6494-19-5

Formula: C₈H₇N₃O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 177.054

Ref: 10-F076709

3-Methyl-6-nitroindazole

Controlled Product

CAS: 6494-19-5

Applications 3-Methyl-6-nitroindazole a reactant used in the preparation of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
References Mei, Y. et al.: Let. Org. Chem., 9, 276 (2012); Harris, P. et al.: J. Med. Chem., 51, 4632 (2008); Olaussen, K., et al.: Oncogen., 28, 4249 (2009); Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009); Chan, A., et al.: Drugs, 69, 167 (2009)

Formula: C₈H₇N₃O₂

Color and Shape: Neat

Molecular weight: 177.16

Ref: TR-M325555

Pazopanib Impurity 22

CAS: 6494-19-5

Formula: C₈H₇N₃O₂

Molecular weight: 177.2

Ref: ST-EA-CP-P58030