CAS 649735-46-6

Brivanib

Description:

Brivanib, with the CAS number 649735-46-6, is a small molecule that functions primarily as a dual inhibitor of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) signaling pathways. It is classified as an anti-cancer agent, specifically targeting various solid tumors. The compound exhibits a complex chemical structure that allows it to interfere with tumor angiogenesis and growth by inhibiting the receptor tyrosine kinases associated with these pathways. Brivanib has been investigated in clinical trials for its efficacy in treating conditions such as hepatocellular carcinoma and other malignancies. Its pharmacokinetic properties include oral bioavailability, and it is metabolized primarily in the liver. The substance has shown a range of biological activities, including anti-proliferative effects on cancer cells. However, like many targeted therapies, it may also present side effects, which necessitate careful monitoring during treatment. Overall, Brivanib represents a significant advancement in the development of targeted cancer therapies.

Formula: C₁₉H₁₉FN₄O₃

InChI: InChI=1/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1

InChI key: InChIKey=WCWUXEGQKLTGDX-LLVKDONJSA-N

SMILES: O(C=1C=2N(C=C(OC[C@@H](C)O)C2C)N=CN1)C=3C(F)=C4C(=CC3)NC(C)=C4

Synonyms:

• (2R)-1-[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxypropan-2-ol
• (2R)-1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol
• 2-Propanol, 1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-, (2R)-
• Bms-540215
• Brivanib
• Ptk787
• Vatalanib
• (2R)-1-({4-[(4-fluoro-2-Methyl-1H-indol-5-yl)oxy]-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-ol
• Bms540215
• Unii-ddu33B674i
• (2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpy...
• (2R)-1-[4-(4-Fluoro-2-Methyl-1H-indol-5-yloxy)-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]propanol
• (R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo(2,1-F)(1,2,4)triazin-6-yloxy)propan-2-ol
• CS-75
• Brivanib(BMS-540215)
• (2R)-1-[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]oxypr
• 1-[4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-propan-2(R)-ol
• 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo-[2,1-f][1,2,4]triazin-6-yl]oxy]-2
• Brivanib, >=98%
• 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol
• 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol USP/EP/BP
• (R)-1-(4-(4-fluoro-2-Methyl-1H-indol-5-yloxy)-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol, BSM-540215
• (2R)-1-[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]ox
• (R)-1-(4-(4-Fluoro-2-Methyl-1H-indol-5-yloxy)-5-Methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol
• Tyrosine Kinase Inhibitor

1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol

CAS: 649735-46-6

Formula: C₁₉H₁₉FN₄O₃

Purity: 96%

Color and Shape: Solid

Molecular weight: 370.3776

Ref: IN-DA00ECCZ

(R)-1-((4-((4-Fluoro-2-Methyl-1H-Indol-5-Yl)Oxy)-5-Methylpyrrolo[2,1-f][1,2,4]Triazin-6-Yl)Oxy)Propan-2-Ol

CAS: 649735-46-6

(R)-1-((4-((4-Fluoro-2-Methyl-1H-Indol-5-Yl)Oxy)-5-Methylpyrrolo[2,1-f][1,2,4]Triazin-6-Yl)Oxy)Propan-2-Ol

Purity: 96%

Molecular weight: 370.38g/mol

Ref: 54-PC108651

Brivanib

CAS: 649735-46-6

Brivanib

Purity: ≥98%

Molecular weight: 370.38g/mol

Ref: 54-BUP09111

Brivanib

CAS: 649735-46-6

Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against

Formula: C₁₉H₁₉FN₄O₃

Purity: 98.87%

Color and Shape: Solid

Molecular weight: 370.38

Ref: TM-T6036

BMS-540215

CAS: 649735-46-6

Ref: 7W-GW5097