CAS 649735-63-7

L-Alanine,(1R)-2-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-1-methylethylester

Description:

L-Alanine, (1R)-2-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-1-methylethylester, identified by CAS number 649735-63-7, is a complex organic compound characterized by its structural components, which include an alanine moiety and a pyrrolo-triazine derivative. This compound features a chiral center, indicated by the (1R) configuration, which can influence its biological activity and interactions. The presence of a fluorinated indole and a pyrrolo[2,1-f][1,2,4]triazin moiety suggests potential pharmacological properties, possibly related to its role as a bioactive molecule. The ester functional group indicates that it may undergo hydrolysis in biological systems, potentially releasing L-alanine and other active fragments. Its solubility, stability, and reactivity would depend on the specific functional groups and their interactions with solvents and biological targets. Overall, this compound's unique structure may contribute to its utility in medicinal chemistry and drug development, warranting further investigation into its properties and applications.

Formula: C₂₂H₂₄FN₅O₄

InChI: InChI=1S/C22H24FN5O4/c1-11-7-15-16(27-11)5-6-17(19(15)23)32-21-20-13(3)18(8-28(20)26-10-25-21)30-9-12(2)31-22(29)14(4)24/h5-8,10,12,14,27H,9,24H2,1-4H3/t12-,14+/m1/s1

InChI key: InChIKey=LTEJRLHKIYCEOX-OCCSQVGLSA-N

SMILES: O(C=1C=2N(C=C(OC[C@H](OC([C@H](C)N)=O)C)C2C)N=CN1)C=3C(F)=C4C(=CC3)NC(C)=C4

Synonyms:

• (1R)-2-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)-1-methylethyl L-alanine ester
• <span class="text-smallcaps">L</span>-Alanine, (1R)-2-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-1-methylethyl ester
• Bms 582664
• Bms582664
• Brivanib alaninate
• L-Alanine, (1R)-2-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-1-methylethyl ester
• [14C]-Brivanib alaninate
• Unii-U2Y5ofn795 USP/EP/BP
• Brivanib alaninate(BMS-582664)
• Unii-U2Y5ofn795
• Brivanib alaninate BMS-540215
• (S)-(R)-1-((4-((5-Fluoro-2-methyl-1H-indol-6-yl)oxy)-5-methylpyrrolo-[2,1-f][1,2,4]triazin-6-y
• (2R)-1-({4-[(4-fluoro-2-Methyl-1H-indol-5-yl)oxy]-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-yl (2S)-2-aMinopropanoate
• CS-362
• L-Alanine (1R)-2-[[4-[(4-fluoro-2-Methyl-1H-indol-5-yloxy)]-5-Methyl-1H-pyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]isopropyl ester
• (1R)-2-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)-1-methylethyl L-alanine ester Brivanib alaninate (BMS-582664)

Unii-U2Y5ofn795

CAS: 649735-63-7

Formula: C₂₂H₂₄FN₅O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 441.4555

Ref: IN-DA00ECD0

Brivanib (alaninate)

CAS: 649735-63-7

Brivanib (alaninate)

Purity: ≥98%

Molecular weight: 441.46g/mol

Ref: 54-BUP03287

Brivanib alaninate

CAS: 649735-63-7

Formula: C₂₂H₂₄FN₅O₄

Purity: ≥ 95.0%

Color and Shape: White to off-white powder

Molecular weight: 441.46

Ref: 7W-GP1791

Brivanib alaninate

CAS: 649735-63-7

VEGFR2 a tyrosine kinase receptor inhibitor; antineoplastic

Formula: C₂₂H₂₄FN₅O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 441.18123

Ref: 3D-FB64963

Brivanib (alaninate)

CAS: 649735-63-7

Brivanib Alaninate (BMS-582664) is an alaninate salt of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic effect.

Formula: C₂₂H₂₄FN₅O₄

Purity: 99.46% - 99.66%

Color and Shape: Solid

Molecular weight: 441.46

Ref: TM-T2576

Brivanib Alaninate

Controlled Product

CAS: 649735-63-7

Applications A novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor. Antitumor agent.
References Ellis, L., et al.: Eur. J. Cancer, 32A, 2451 (1996), Klagsbrun, M., et al.: Chem. Biol., 6, R217 (1999), Auguste, P., et al.: Cancer Res., 61, 1717 (2001), Bhide, R., et al.: J. Med. Chem., 49, 2143 (2006),

Formula: C₂₂H₂₄FN₅O₄

Color and Shape: Neat

Molecular weight: 441.455

Ref: TR-B677640

Brivanib Alaninate

CAS: 649735-63-7

Formula: C₂₂H₂₄FN₅O₄

Molecular weight: 441.46

Ref: ST-EA-CP-B82002