CAS 65-49-6

4-Aminosalicylic acid

Description:

4-Aminosalicylic acid, also known as para-aminosalicylic acid (PAS), is an aromatic compound with the molecular formula C7H9NO3. It features both an amino group (-NH2) and a carboxylic acid group (-COOH) attached to a salicylic acid backbone, making it a member of the salicylate family. This compound appears as a white to off-white crystalline powder and is soluble in water, which enhances its bioavailability. 4-Aminosalicylic acid is primarily known for its use as an antitubercular agent, particularly in the treatment of tuberculosis, especially in cases resistant to other medications. Its mechanism of action involves inhibiting the synthesis of folic acid in bacteria, thereby impeding their growth. Additionally, it has been studied for its potential antioxidant properties. While generally well-tolerated, it can cause side effects such as gastrointestinal disturbances and hypersensitivity reactions. As with any pharmaceutical compound, proper handling and dosage are crucial to ensure safety and efficacy in therapeutic applications.

Formula: C₇H₇NO₃

InChI: InChI=1/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)

InChI key: InChIKey=WUBBRNOQWQTFEX-UHFFFAOYSA-N

SMILES: C(O)(=O)C1=C(O)C=C(N)C=C1

Synonyms:

• 2-Hydroxy-4-aminobenzoic acid
• 3-Hydroxy-4-carboxyaniline
• 4-Amino-2-hydroxybenzoic acid
• 4-Aminosalicylsaure
• 4-Asa
• 4-Carboxy-3-hydroxyaniline
• Acide 4-aminosalicylique
• Acido 4-Aminosalicilico
• Amino-PAS
• Aminosalicylic Acid
• Apacil
• Apas
• Benzoic acid, 4-amino-2-hydroxy-
• Deapasil
• Entepas
• Euteropas
• Gabbropas
• Granupas
• Monopass
• Nsc 2083
• Nsc 211698
• Osacyl
• PAS
• PAS (acid)
• Pamacyl
• Pamisyl
• Para-Pas
• Para-aminosalicylic acid
• Paramycin
• Parasal
• Parasalicil
• Parasalindon
• Pasa
• Pasalon
• Pasara
• Pasem
• Paser
• Pask
• Pasmed
• Pasnodia
• Pasolac
• Propasa
• Rezipas
• Salicylic acid, 4-amino-
• Sanipirol-4
• p-Aminosalicylic acid
• SCHIFF REAGENT
• SCHIFF REAGENT, HOTCHKISS/MCMANUS
• SCHIFF'S REAGENT FOR ALDEHYDES
• SCHIFFS REAGENT
• SCHIFF'S REAGENT
• PERIODIC ACID-SCHIFF
• FUCHSIN SULFUROUS ACID
• 4-amino-2-hydroxy-benzoicaci
• SCHIFF REAGENT SOLUTION, MODIFIED
• 4-Amino-2-hydroxbenzoicacid
• 4-Aminosalicyclic acid
• 4-AMINOSALICYLIC ACID
• SCHIFF'S FUCHSIN-SULFITE REAGENT

4-Aminosalicylic acid, 98+%

CAS: 65-49-6

Competitive pteridine synthetase inhibitor, has antibacterial capable of inhibiting the growth of Mycobacterium tuberculosis. It inhibits NF-B and folic acid synthesis. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and labe

Formula: C₇H₇NO₃

Purity: 98+%

Color and Shape: White to pale brown or pale grey, Powder

Molecular weight: 153.14

Ref: 02-B23289

Aminosalicylic Acid

CAS: 65-49-6

Aromatic amino-alcohol-phenols, aromatic amino-acid-phenols and other aromatic amino compounds with oxygen function

Formula: C₇H₇NO₃

Color and Shape: White Beige Powder

Molecular weight: 153.04259

Ref: 45-1026401

4-Amino-2-hydroxybenzoic acid

CAS: 65-49-6

Formula: C₇H₇NO₃

Purity: 96%

Color and Shape: Solid

Molecular weight: 153.1354

Ref: IN-DA003KS5

4-Aminosalicylic acid

CAS: 65-49-6

4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.

Formula: C₇H₇NO₃

Purity: 97.03% - 98.39%

Color and Shape: Minute Crystals From Alc Solid

Molecular weight: 153.14

Ref: TM-T1296

4-Aminosalicylic acid

CAS: 65-49-6

4-Aminosalicylic acid

Purity: ≥95%

Molecular weight: 153.14g/mol

Ref: 54-BUP19585

4-Aminosalicylic acid

CAS: 65-49-6

Formula: C₇H₇NO₃

Purity: (Titration) 98.5 - 101.5 %

Color and Shape: White to pale yellow or pale brown

Molecular weight: 153.14

Ref: 7W-GM8827

Mesalazine (Mesalamine) EP Impurity E

CAS: 65-49-6

Formula: C₇H₇NO₃

Color and Shape: Brown Solid

Molecular weight: 153.14

Ref: 4Z-M-1740

4-Amino-2-hydroxybenzoic acid

CAS: 65-49-6

4-Amino-2-hydroxybenzoic acid

Formula: C₇H₇NO₃

Purity: 99%

Color and Shape: nearly white powder

Molecular weight: 153.13538g/mol

Ref: 54-OR22063

4-Aminosalicylic acid

CAS: 65-49-6

Formula: C₇H₇NO₃

Color and Shape: Neat

Molecular weight: 153.14

Ref: 04-C10227010

4-Aminosalicylic acid (Standard)

CAS: 65-49-6

4-Aminosalicylic acid (Standard) is the standard substance of 4-Aminosalicylic acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.

Formula: C₇H₇NO₃

Molecular weight: 153.14

Ref: TM-TMSM-0270

4-Aminosalicylic Acid

CAS: 65-49-6

Formula: C₇H₇NO₃

Purity: >98.0%(T)

Color and Shape: White to Light gray to Light orange powder to crystal

Molecular weight: 153.14

Ref: 3B-A0420

4-Aminosalicylic Acid

CAS: 65-49-6

Impurity Mesalazine EP Impurity E
Stability Hygroscopic
Applications 4-Aminosalicylic Acid is an antibiotic used to treat tuberculosis.
References Horita, Y., et al.: Bioorg. Med. Chem. Lett., 19, 6313 (2009); Martins, M., et al.: J. Biol. Chem., 284, 18726 (2009); Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010);

Formula: C₇H₇NO₃

Color and Shape: Beige

Molecular weight: 153.14

Ref: TR-A629220

Mesalazine EP Impurity E

CAS: 65-49-6

Formula: C₇H₇O₃N

Molecular weight: 153.14

Ref: ST-EA-CP-M11005

4-Aminosalicylic acid

CAS: 65-49-6

4-Aminosalicylic acid (4-ASA) is a drug with anti-inflammatory and analgesic properties. It is used in the treatment of bowel disease, including ulcerative colitis and Crohn's disease. 4-ASA binds to the 4th carbon on the para position of p-hydroxybenzoic acid, which is a metabolite of salicylic acid. This binding inhibits the activity of proton pumps that are responsible for maintaining intracellular pH levels in cells. It also prevents the production of inflammatory prostaglandins by inhibiting cyclooxygenase 1 and 2, which are enzymes that catalyze the conversion of arachidonic acid to prostaglandin H2. 4-ASA also has an effect on bacterial infections by interfering with hydrogen bonding interactions between bacterial dna gyrase and dna topoisomerase II, preventing DNA replication. The x-ray crystal structures have demonstrated that 4-ASA

Formula: C₇H₇NO₃

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 153.14 g/mol

Ref: 3D-FA10792

4-Amino-2-hydroxybenzoic acid

CAS: 65-49-6

Formula: C₇H₇NO₃

Purity: 95%

Color and Shape: Powder

Molecular weight: 153.137

Ref: 10-F078671