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CAS 65022-15-3

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Z-glycyl-L-proline-4-nitroanilide

Description:
Z-glycyl-L-proline-4-nitroanilide, with the CAS number 65022-15-3, is a synthetic peptide derivative commonly used in biochemical research, particularly in the study of proteolytic enzymes. This compound features a Z (benzyloxycarbonyl) protecting group on the amino group of glycine, which enhances its stability and solubility. The presence of L-proline contributes to its structural rigidity, while the 4-nitroanilide moiety serves as a chromogenic or fluorogenic reporter, making it useful in enzyme assays. The compound is typically characterized by its ability to undergo hydrolysis in the presence of specific proteases, releasing detectable products that can be quantified. Its molecular structure includes both peptide bonds and aromatic systems, which can influence its reactivity and interaction with biological macromolecules. Overall, Z-glycyl-L-proline-4-nitroanilide is valuable in the development of substrates for studying enzyme kinetics and mechanisms in various biological contexts.
Formula:C21H22N4O6
InChI:InChI=1/C21H22N4O6/c26-19(13-22-21(28)31-14-15-5-2-1-3-6-15)24-12-4-7-18(24)20(27)23-16-8-10-17(11-9-16)25(29)30/h1-3,5-6,8-11,18H,4,7,12-14H2,(H,22,28)(H,23,27)/t18-/m0/s1
SMILES:c1ccc(cc1)COC(=NCC(=O)N1CCC[C@H]1C(=O)Nc1ccc(cc1)N(=O)=O)O
Synonyms:
  • Z-Gly-Pro-pNA
  • Z-Gly-Pro-4-nitroanilide
  • N-[(benzyloxy)carbonyl]glycyl-N-(4-nitrophenyl)-L-prolinamide
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