CAS 65144-34-5

N-Methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone

Description:

N-Methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone, with the CAS number 65144-34-5, is a synthetic peptide derivative that exhibits specific biochemical properties. This compound is characterized by its structure, which includes a methoxysuccinyl group and a chloromethyl ketone moiety, contributing to its reactivity and potential applications in biochemical research. It is often utilized as a protease inhibitor, particularly in studies involving serine proteases, due to its ability to form covalent bonds with the active site of these enzymes. The presence of amino acid residues such as alanine, proline, and valine in its sequence suggests that it may mimic natural substrates, allowing for selective inhibition. Additionally, the methoxy and chloromethyl groups enhance its solubility and stability in various solvents, making it suitable for laboratory use. Overall, this compound serves as a valuable tool in the study of enzyme mechanisms and the development of therapeutic agents targeting proteolytic pathways.

Formula: C₂₂H₃₅ClN₄O₇

InChI: InChI=1S/C22H35ClN4O7/c1-12(2)19(16(28)11-23)26-21(32)15-7-6-10-27(15)22(33)14(4)25-20(31)13(3)24-17(29)8-9-18(30)34-5/h12-15,19H,6-11H2,1-5H3,(H,24,29)(H,25,31)(H,26,32)/t13-,14-,15-,19-/m0/s1

InChI key: InChIKey=PJGDFLJMBAYGGC-XLPNERPQSA-N

SMILES: C(N[C@H](C(CCl)=O)C(C)C)(=O)[C@H]1N(C([C@@H](NC([C@@H](NC(CCC(OC)=O)=O)C)=O)C)=O)CCC1

Synonyms:

• <span class="text-smallcaps">L</smallcap>-Prolinamide, N-(4-methoxy-1,4-dioxobutyl)-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanyl-N-[(1S)-3-chloro-1-(1-methylethyl)-2-oxopropyl]-
• <span class="text-smallcaps">L</smallcap>-Prolinamide, N-(4-methoxy-1,4-dioxobutyl)-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanyl-N-[3-chloro-1-(1-methylethyl)-2-oxopropyl]-, (S)-
• Elastase inhibitor III
• MeOSuc-Ala-Ala-Pro-Val-chloromethylketone
• N-(4-Methoxy-1,4-dioxobutyl)-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>L</smallcap>-alanyl-N-[(1S)-3-chloro-1-(1-methylethyl)-2-oxopropyl]-<smallcap>L</span>-prolinamide
• N-(4-methoxy-4-oxobutanoyl)-L-alanyl-L-alanyl-N-[(1S)-3-chloro-1-(1-methylethyl)-2-oxopropyl]-L-prolinamide
• N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone
• L-Prolinamide, N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-[3-chloro-1-(1-methylethyl)-2-oxopropyl]-, (S)-
• L-Prolinamide, N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-[(1S)-3-chloro-1-(1-methylethyl)-2-oxopropyl]-
• SPCK
• N-(4-Methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-[(1S)-3-chloro-1-(1-methylethyl)-2-oxopropyl]-L-prolinamide

MeOSuc-Ala-Ala-Pro-Val-chloromethylketone

CAS: 65144-34-5

Inhibitor of human neutrophil elastase. MeOSuc-AAPV-CMK was used for crystallizing hamster chymase 2.

Formula: C₂₂H₃₅ClN₄O₇

Purity: 95.6%

Color and Shape: White Powder

Molecular weight: 503.0

Ref: 01-4009927

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone elastase inhibitor

CAS: 65144-34-5

Formula: C₂₂H₃₅ClN₄O₇

Molecular weight: 502.99

Ref: 7W-GL9803

MeOSuc-Ala-Ala-Pro-Val-chloromethylketone

CAS: 65144-34-5

MeOSuc-Ala-Ala-Pro-Val-chloromethylketone is a serine protease inhibitor that has been shown to be effective against influenza virus and HIV. It was found to be active against a number of serine proteases, such as trypsin, chymotrypsin, and elastase. MeOSuc-Ala-Ala-Pro-Val-chloromethylketone also has chemotactic activity in thp1 cells and lung fibroblasts. It is activated by the addition of water and has been shown to inhibit the growth of soybean trypsin. However, it does not have any effect on human trypsin.

Formula: C₂₂H₃₅ClN₄O₇

Purity: Min. 95%

Molecular weight: 502.99 g/mol

Ref: 3D-FM111010

MeOSuc-AAPV-CMK

CAS: 65144-34-5

MeOSuc-AAPV-CMK (Elastase Inhibitor III) serves as an inhibitor of elastase, as well as cathepsin G and proteinase 3, and impedes leukocyte elastase-mediated

Formula: C₂₂H₃₅ClN₄O₇

Color and Shape: Solid

Molecular weight: 502.99

Ref: TM-T78633