CAS 65147-09-3

N-T-boc-leu-gly-arg 7-amido-4-*methylcoumarin ace

Description:

N-T-boc-leu-gly-arg 7-amido-4-methylcoumarin acetate, identified by its CAS number 65147-09-3, is a synthetic compound commonly used in biochemical research, particularly in the study of proteolytic enzymes and peptide synthesis. This compound features a tert-butyloxycarbonyl (Boc) protecting group, which is often employed to protect amine functionalities during chemical reactions. The presence of the amino acids leucine (leu), glycine (gly), and arginine (arg) in its structure indicates that it is a peptide derivative, which can influence its biological activity and interactions. The 7-amido-4-methylcoumarin moiety serves as a fluorescent tag, making it useful for monitoring enzymatic activity or peptide cleavage in various assays. The acetate group enhances solubility and stability in biological systems. Overall, this compound is valuable in the development of peptide-based probes and in the exploration of enzyme kinetics, contributing to advancements in fields such as drug discovery and molecular biology.

Formula: C₂₉H₄₃N₇O₇

Synonyms:

• Boc-Leu-Gly-Arg-AMC
• Boc-Leu-Gly-Arg-Amc Acetate Salt
• N(tert-BOC)-Leu-Gly-Arg-7-amido-4-methylcoumarin acetate
• L-Argininamide, N-[(1,1-dimethylethoxy)carbonyl]-L-leucylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• N-T-boc-leu-gly-arg 7-amido-4-*methylcoumarin ace
• BOC-LEU-GLY-ARG-AMC ACOH
• BOC-LEU-GLY-ARG-MCA HYDROCHLORIDE
• N-T-BOC-LEU-GLY-ARG 7-AMIDO-4-METHYLCOUMARIN ACETATE)
• BOC-LGR-AMC
• N-ALPHA-T-BOC-L-LEU-GLY-L-ARG-4-METHYLCOUMARYL-7-AMIDE
• BOC-LEU-GLY-ARG-MCA
• Boc-Leu-Gly-Arg-7-amido-4-methylcoumarin acetate salt

Boc-Leu-Gly-Arg-AMC

CAS: 65147-09-3

Boc-LGR-AMC, a specific fluorogenic substrate for complement component C3/C5 convertases, coagulation factor Xa, and soybean trypsin-like enzyme. It is also hydrolyzed by macropain, a high molecular weight thiol proteinase from human erythrocytes. Stock solutions of Boc-LGR-AMC are best prepared in DMSO.

Formula: C₂₉H₄₃N₇O₇

Purity: > 99%

Color and Shape: White Lyophilisate

Molecular weight: 601.7

Ref: 01-4005550

Boc-Leu-Gly-Arg-AMC

CAS: 65147-09-3

Boc-Leu-Gly-Arg-AMC

Purity: ≥95%

Molecular weight: 601.71g/mol

Ref: 54-BUP22193

Boc-Leu-Gly-Arg-AMC

CAS: 65147-09-3

Boc-Leu-Gly-Arg-AMC is a fluorogenic substrate for detecting C3/C5 convertases, factor Xa, and soybean trypsin-like enzymes; it's also hydrolyzed by macropain.

Formula: C₂₉H₄₃N₇O₇

Purity: 99.53%

Color and Shape: Solid

Molecular weight: 601.69

Ref: TM-TP2169

Boc-Leu-Gly-Arg-AMC acetate salt

CAS: 65147-09-3

Boc-Leu-Gly-Arg-AMC acetate salt is a potential drug target for leishmaniasis. It inhibits the growth of Leishmania by binding to the 17β-estradiol receptor and inhibiting protein synthesis. This drug also has a hydrolytic activity against proteins, which is activated by an acidic environment. It has been shown to inhibit the growth of bacteria including Staphylococcus aureus and Chlamydia pneumoniae by inhibiting urokinase-type plasminogen activator (uPA) and serine protease activities. Boc-Leu-Gly-Arg-AMC acetate salt has also been shown to inhibit cellular proliferation in cancer cells.

Formula: C₂₉H₄₃N₇O₇•C₂H₄O₂

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 661.74 g/mol

Ref: 3D-FB110486

Boc-Leu-Gly-Arg-AMC

CAS: 65147-09-3

Boc-Leu-Gly-Arg-AMC is a peptide that binds to the receptor for N-methyl-D-aspartate (NMDA) and inhibits the ion channel. It has been used as a research tool to study NMDA receptor interactions, as well as in cell biology and pharmacology. Boc-Leu-Gly-Arg-AMC is a high purity, ionic analog of glutamate that binds to the NMDA receptor without activating it, thereby inhibiting ion flow through the channel. This inhibition can be reversed by adding excess glutamate or glycine. The binding of this compound to the NMDA receptor has been shown to block activation of voltage gated calcium channels and reduce neuronal excitation, which may provide an alternative therapeutic strategy for controlling seizures or other neurological disorders.

Formula: C₂₉H₄₃N₇O₇

Purity: Min. 95%

Molecular weight: 601.69 g/mol

Ref: 3D-MLG-3102-V