CAS 65147-21-9

pro-phe-arg 7-amido-4-methylcoumarin

Description:

Pro-phe-arg 7-amido-4-methylcoumarin, identified by its CAS number 65147-21-9, is a synthetic compound that belongs to the class of coumarin derivatives. This substance is characterized by its unique structure, which includes a coumarin core modified with an amide group and a peptide sequence consisting of proline (pro), phenylalanine (phe), and arginine (arg). The presence of the 7-amido group enhances its solubility and reactivity, making it useful in biochemical applications, particularly as a fluorescent probe for studying proteolytic activity. The coumarin moiety is known for its fluorescent properties, which can be exploited in various assays and imaging techniques. Additionally, the peptide sequence contributes to its specificity in interactions with enzymes or proteins, making it valuable in research related to enzymatic activity and protein interactions. Overall, pro-phe-arg 7-amido-4-methylcoumarin serves as an important tool in biochemical research, particularly in the fields of molecular biology and biochemistry.

Formula: C₃₀H₃₇N₇O₅

InChI: InChI=1/C30H37N7O5/c1-18-15-26(38)42-25-17-20(11-12-21(18)25)35-23(10-6-14-34-30(31)32)28(40)37-29(41)24(16-19-7-3-2-4-8-19)36-27(39)22-9-5-13-33-22/h2-4,7-8,11-12,15,17,22-24,33,35H,5-6,9-10,13-14,16H2,1H3,(H,36,39)(H4,31,32,34)(H,37,40,41)/t22-,23-,24-/m0/s1

SMILES: Cc1cc(=O)oc2cc(ccc12)N[C@@H](CCCNC(=N)N)C(=NC(=O)[C@H](Cc1ccccc1)N=C([C@@H]1CCCN1)O)O

Synonyms:

• H-Pro-Phe-Arg-AMC
• L-prolyl-N-{(2S)-5-[(diaminomethylidene)amino]-2-[(4-methyl-2-oxo-2H-chromen-7-yl)amino]pentanoyl}-L-phenylalaninamide
• H-Pro-Phe-Arg-Amc Acetate Salt

H-Pro-Phe-Arg-AMC

CAS: 65147-21-9

A highly sensitive, fluorogenic substrate for plasma as well as pancreatic and urinary kallikreins. PFR-AMC is also cleaved rapidly by soybean trypsin-like enzyme. Stock solutions of this substrate are best prepared in DMSO.

Formula: C₃₀H₃₇N₇O₅

Purity: 99.09%

Color and Shape: White

Molecular weight: 575.67

Ref: 01-4004023

H-Pro-Phe-Arg-AMC acetate salt

CAS: 65147-21-9

Formula: C₃₀H₃₇N₇O₅

Molecular weight: 575.6587

Ref: IN-DA00EC5V

H-Pro-Phe-Arg-AMC acetate salt

CAS: 65147-21-9

Fluorogenic substrate targeting pancreatic and urinary Kallikrein

Formula: C₃₀H₃₇N₇O₅·C₂HF₃O₂

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 575.66 g/mol

Ref: 3D-FP110516