CAS 65195-51-9

Avermectin A1a

Description:

Avermectin A1a, with the CAS number 65195-51-9, is a macrocyclic lactone compound that belongs to the class of avermectins, which are derived from the fermentation of the soil bacterium Streptomyces avermitilis. This compound exhibits potent antiparasitic and insecticidal properties, making it widely used in veterinary medicine and agriculture. Avermectin A1a functions by interfering with the neurotransmission in parasites, leading to paralysis and death. It is characterized by its complex molecular structure, which includes multiple rings and functional groups that contribute to its biological activity. The compound is typically administered in formulations that enhance its stability and efficacy. Avermectin A1a is known for its low toxicity to mammals, which makes it a preferred choice for treating parasitic infections in livestock and pets. However, it is important to handle it with care, as it can be harmful to non-target organisms, particularly aquatic life. Overall, Avermectin A1a is a significant agent in pest control and veterinary therapeutics.

Formula: C₄₉H₇₄O₁₄

InChI: InChI=1S/C49H74O14/c1-12-26(2)43-29(5)18-19-48(63-43)24-35-21-34(62-48)17-16-28(4)42(60-40-23-38(54-10)45(32(8)58-40)61-39-22-37(53-9)41(50)31(7)57-39)27(3)14-13-15-33-25-56-46-44(55-11)30(6)20-36(47(51)59-35)49(33,46)52/h13-16,18-20,26-27,29,31-32,34-46,50,52H,12,17,21-25H2,1-11H3/b14-13+,28-16+,33-15+/t26-,27-,29-,31-,32-,34+,35-,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46+,48+,49+/m0/s1

InChI key: InChIKey=AFSHKCWTGFDXJR-SQOHEDJBSA-N

SMILES: O[C@@]1/2[C@]3([C@H](OC)C(C)=C[C@]1(C(=O)O[C@@]4(C[C@]5(O[C@@](C4)(C/C=C(\C)/[C@@H](O[C@H]6C[C@H](OC)[C@@H](O[C@H]7C[C@H](OC)[C@@H](O)[C@H](C)O7)[C@H](C)O6)[C@@H](C)\C=C\C=C2/CO3)[H])O[C@]([C@H](CC)C)([C@@H](C)C=C5)[H])[H])[H])[H]

Synonyms:

• Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran]-17-one, 7-[[2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranosyl]oxy]-5′,6,6′,7,10,11,14,15,17a,20,20a,20b-dodecahydro-20b-hydroxy-20-methoxy-5′,6,8,19-tetramethyl-6′-(1-methylpropyl)-, [6S-[2aE,4E,6R*,7R*,8E,11S*,13R*[5′R*,6′S*(R*)],15R*,17aS*,20S*,20aS*,20bR*]]-
• Antibiotic C 076A1a
• [6S-[2aE,4E,6R*,7R*,8E,11S*,13R*[5′R*,6′S*(R*)],15R*,17aS*,20S*,20aS*,20bR*]]-7-[[2,6-Dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranosyl]oxy]-5′,6,6′,7,10,11,14,15,17a,20,20a,20b-dodecahydro-20b-hydroxy-20-methoxy-5′,6,8,19-tetramethyl-6′-(1-methylpropyl)spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran]-17-one
• Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], avermectin A1a deriv.
• Avermectin A1a

Abamectin A1a

CAS: 65195-51-9

Formula: C₄₉H₇₄O₁₄

Molecular weight: 887.12

Ref: 4Z-A-4215

Avermectin A1a (>90%)

CAS: 65195-51-9

Formula: C₄₉H₇₄O₁₄

Purity: >90%

Color and Shape: White To Off-White

Molecular weight: 887.1

Ref: TR-A107020

Avermectin a1a

CAS: 65195-51-9

Avermectin A1a is a macrocyclic lactone used primarily as an anthelmintic and insecticide. It is derived from the fermentation of the soil bacterium *Streptomyces avermitilis*. The compound works through a neurotoxic mode of action, binding to glutamate-gated chloride channels in nerve and muscle cells of invertebrates, leading to paralysis and subsequent death of the parasites. This mechanism is highly specific, primarily affecting nematodes and arthropods.

Formula: C₄₉H₇₄O₁₄

Purity: 90%

Molecular weight: 887.1 g/mol

Ref: 3D-QCA19551

Avermectin A1a

CAS: 65195-51-9

Formula: C₄₉H₇₄O₁₄

Molecular weight: 887.12

Ref: ST-EA-CP-A133004