CAS 65271-80-9
:Mitoxantrone
Description:
Mitoxantrone is a synthetic anthracenedione derivative primarily used as an antineoplastic agent in the treatment of certain cancers, including breast cancer and leukemia, as well as in multiple sclerosis. It exhibits a blue color and is characterized by its ability to intercalate DNA, disrupting the replication process and ultimately leading to cell death. Mitoxantrone functions as a topoisomerase II inhibitor, preventing the enzyme from relieving torsional strain during DNA replication. Its pharmacokinetics involve moderate absorption and distribution, with a relatively long half-life, allowing for less frequent dosing. The drug is typically administered intravenously and is known for its potential side effects, which can include cardiotoxicity, myelosuppression, and gastrointestinal disturbances. Mitoxantrone's efficacy is often balanced against these risks, necessitating careful monitoring during treatment. Additionally, it is classified as a category D drug in pregnancy, indicating potential risks to the fetus. Overall, Mitoxantrone remains a critical option in oncological and neurological therapies, despite its associated risks.
Formula:C22H28N4O6
InChI:InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2
InChI key:InChIKey=KKZJGLLVHKMTCM-UHFFFAOYSA-N
SMILES:N(CCNCCO)C1=C2C(=C(NCCNCCO)C=C1)C(=O)C=3C(C2=O)=C(O)C=CC3O
Synonyms:- 1,4-Bis[(2-(2-hydroxyethylamino)ethyl)amino]-5,8-dihydroxyanthraquinone
- 1,4-Dihydroxy-5,8-bis-[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone
- 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione
- Dhaq
- Dihydroxyanthraquinone
- Mitox
- Mitoxanthrone
- Mitoxantrone
- Mitozantrone
- Nimitoxantron
- Novantron
- Novantrone
- Nsc 279836
- Ralenova
- See more synonyms
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Found 10 products.
Mitoxantrone Dihydrochloride
CAS:Formula:C22H28N4O6·2HClPurity:>97.0%(HPLC)Color and Shape:Dark green to Dark purple to Black powder to crystalMolecular weight:517.401,4-dihydroxy-5,8-bis[2-[(1,1,2,2-tetradeuterio-2-hydroxyethyl)amino]ethylamino]anthracene-9,10-dione
CAS:Formula:C22H28N4O6Purity:97%Color and Shape:SolidMolecular weight:444.4809Mitoxantrone
CAS:Formula:C22H28N4O6Purity:>95.0%(HPLC)Color and Shape:Light orange to Dark red to Black powder to crystalMolecular weight:444.49Mitoxantrone
CAS:Formula:C22H28N4O6Purity:≥ 97.0%Color and Shape:Blue to dark blue or dark blue-green powder or crystalsMolecular weight:444.48Mitoxantrone
CAS:<p>Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.</p>Formula:C22H28N4O6Purity:96.29% - 98.74%Color and Shape:Blue PowderMolecular weight:444.48Mitoxantrone
CAS:Controlled Product<p>Applications Mitoxantrone is a DNA intercalating drug. Mitoxantrone inhibits DNA synthesis. Mitoxantrone is used as an anti-cancer agent.<br>References McDonald, M., et al.: Drugs Exp. Clin. Res., 10, 745 (1984), Beijnen, J.H., et al.: Anal. Profiles Drug Subs., 17, 221 (1988),<br></p>Formula:C22H28N4O6Color and Shape:NeatMolecular weight:444.48Ref: 10-F801706
1gTo inquire5gTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire250mgTo inquireMitoxantrone
CAS:<p>Mitoxantrone is a chemotherapeutic agent, classified as an anthracenedione, which is a synthetic compound derived from anthracycline antibiotics. Its mode of action involves intercalation into DNA, resulting in the inhibition of DNA and RNA synthesis. This leads to disruption of replication and transcription processes within the cell, ultimately causing cytotoxicity and cell death.</p>Formula:C22H28N4O6Purity:Min. 95 Area-%Color and Shape:Blue PowderMolecular weight:444.48 g/mol
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