CAS 65277-42-1
:Ketoconazole
Description:
Ketoconazole is an antifungal medication primarily used to treat various fungal infections, including those affecting the skin and mucous membranes. It belongs to the class of imidazole derivatives and functions by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes, thereby disrupting their integrity and function. Ketoconazole is characterized by its relatively low solubility in water but is soluble in organic solvents, which influences its formulation in topical and oral dosage forms. The substance has a molecular formula that reflects its complex structure, which includes multiple rings and functional groups that contribute to its pharmacological activity. Ketoconazole is known for its broad-spectrum antifungal properties, making it effective against a variety of fungi, including dermatophytes and yeasts. However, its use has been associated with potential side effects, including hepatotoxicity and endocrine effects, leading to restrictions in its systemic use. As a result, it is often prescribed in topical formulations for localized infections or in specific cases where systemic treatment is warranted.
Formula:C26H28Cl2N4O4
InChI:InChI=1/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/s2
InChI key:InChIKey=XMAYWYJOQHXEEK-MKNUCDGGNA-N
SMILES:C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(C(C)=O)CC3)CO1)C4=C(Cl)C=C(Cl)C=C4)N5C=CN=C5
Synonyms:- 1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethanone
- 1-[4-(4-{[(2S,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethanone
- 1-[4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethanone
- 1-acetyl-4-(4-{[(2R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
- Brizoral
- Cis-1-Acetyl-4-(4-((2-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl)Methoxy)Phenyl)Piperazine
- Ethanone, 1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]-, rel-
- Fungarest
- Fungoral
- Ketoconazol
- Ketoderm
- Ketoisdin
- Ketozoral
- Micosin
- Nizaral
- Nizoral
- Nizral
- Onofin K
- Orifungal M
- Panfungol
- Phytorol
- Piperazine, 1-acetyl-4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-, rel-
- Piperazine, 1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-, cis-
- R 41400
- Tocon
- cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
- rel-1-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]ethanone
- See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 24 products.
Ketoconazole
CAS:Formula:C26H28Cl2N4O4Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:531.43Ketoconazole, 98%
CAS:Potent inhibitor of cytochrome P450c17Formula:C26H28Cl2N4O4Purity:98%Color and Shape:White, PowderMolecular weight:531.43KETOCONAZOLE CRS
CAS:KETOCONAZOLE CRSFormula:C26H28Cl2N4O4Color and Shape:PowderMolecular weight:531.4309KETOCONAZOLE RS
CAS:KETOCONAZOLE RSFormula:C26H28Cl2N4O4Color and Shape:PowderMolecular weight:531.4309Ketoconazole
CAS:KetoconazoleFormula:C26H28CI2N4O4Purity:100.0%Color and Shape:White. To. Off-WhiteMolecular weight:726.02Ketoconazole
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C26H28Cl2N4O4Color and Shape:White Off-White PowderMolecular weight:530.148761-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one
CAS:Formula:C26H28Cl2N4O4Purity:98%Color and Shape:SolidMolecular weight:531.4309Ketoconazole
CAS:Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.Formula:C26H28Cl2N4O4Purity:99.53% - 99.95%Color and Shape:Crystals From 4-Methylpentanone SolidMolecular weight:531.43Ketoconazole
CAS:Formula:C26H28Cl2N4O4Purity:≥ 99.0% (anhydrous basis)Color and Shape:White to off-white crystalline powderMolecular weight:531.43Ketoconazole
CAS:Formula:C26H28Cl2N4O4Color and Shape:White To Off-White SolidMolecular weight:531.44Ketoconazole, EP grade
CAS:Formula:C26H28Cl2N4O4Purity:(Titration) 99.0 - 101.0 % (dried basis)Color and Shape:White to almost white powderMolecular weight:531.43(±)-Ketoconazole-d4(piperazine-3,3,5,5-d4) (cis--isomers)
CAS:Purity:98 atom % DColor and Shape:White To Off-White SolidMolecular weight:535.46Ketoconazole
CAS:Controlled ProductApplications Inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor. Inhibitor of exosome secretion.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986); Scientific Reports 8: 8161 (2018)Formula:C26H28Cl2N4O4Color and Shape:NeatMolecular weight:531.43Ketoconazole
CAS:Ketoconazole is an azole antifungal compound with a mode of action that inhibits ergosterol synthesis, disrupting fungal cell membranes. It is used for treating fungal infections of the skin and scalp.Formula:C26H28Cl2N4O4Color and Shape:White PowderMolecular weight:531.43 g/molKetoconazole
CAS:M02048 - Ketoconazole
Formula:C26H28Cl2N4O4Purity:98%Color and Shape:SolidMolecular weight:531.43Ketoconazole-d4
CAS:Controlled ProductFormula:C26D4H24Cl2N4O4Color and Shape:NeatMolecular weight:535.456
![1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phen…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA00352N.jpg&w=3840&q=75)
