CAS 654671-77-9
:Sitagliptin phosphate monohydrate
Description:
Sitagliptin phosphate monohydrate is a pharmaceutical compound primarily used in the management of type 2 diabetes mellitus. It functions as a dipeptidyl peptidase-4 (DPP-4) inhibitor, which enhances the body's incretin levels, leading to increased insulin secretion and decreased glucagon levels in response to meals. This mechanism helps to lower blood glucose levels. The substance appears as a white to off-white crystalline powder and is soluble in water, which facilitates its absorption in the body. Its molecular formula includes elements such as carbon, hydrogen, nitrogen, oxygen, and phosphorus, reflecting its complex structure. Sitagliptin phosphate monohydrate is typically administered orally and is often prescribed in combination with other antidiabetic medications to improve glycemic control. As with any medication, it is essential to monitor for potential side effects, which may include gastrointestinal issues or allergic reactions. Overall, Sitagliptin phosphate monohydrate represents a significant advancement in diabetes treatment, offering a targeted approach to managing blood sugar levels.
Formula:C16H15F6N5O·H3O4P·H2O
InChI:InChI=1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4);1H2/t9-;;/m1../s1
InChI key:InChIKey=GQPYTJVDPQTBQC-KLQYNRQASA-N
SMILES:C(F)(F)(F)C=1N2C(CN(C(C[C@@H](CC3=C(F)C=C(F)C(F)=C3)N)=O)CC2)=NN1.P(=O)(O)(O)O.O
Synonyms:- (2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine dihydrogen phosphate monohydrate
- (3R)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one phosphate hydrate (1:1:1)
- 1,2,4-Triazolo[4,3-a]pyrazine, 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-, phosphate (1:1), monohydrate
- 1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)-, phosphate, hydrate (1:1:1)
- 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate monohydrate
- Sitagliptin Phosphate Monohydrate
- Sitagliptin phosephate monohydrate
- Sitagliptin phosphate hydrate
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Found 18 products.
Sitagliptin Phosphate
CAS:Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structureFormula:C16H15F6N5O·H3PO4·H2OColor and Shape:White Off-White PowderMolecular weight:523.105541,2,4-Triazolo[4,3-a]pyrazine,7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-, phosphate (1:1), monohydrate
CAS:Formula:C16H20F6N5O6PPurity:98%Color and Shape:SolidMolecular weight:523.3241Sitagliptin phosphate monohydrate
CAS:Sitagliptin phosphate monohydratePurity:≥98%Molecular weight:523.33g/molSitagliptin phosphate monohydrate
CAS:Sitagliptin phosphate monohydratePurity:98%Molecular weight:523.32g/molSitagliptin phosphate monohydrate
CAS:Formula:C16H15F6N5O·H3PO4·H2OPurity:≤ 0.5%Color and Shape:White to almost white powderMolecular weight:505.31Sitagliptin Monophosphate Monohydrate
CAS:Formula:C16H15F6N5O·H2O·H3O4PColor and Shape:White To Off-White SolidMolecular weight:407.32 18.02 98.00Sitagliptin Phosphate Monohydrate
CAS:Controlled ProductFormula:C16H15F6N5O·H2O·H3O4PColor and Shape:NeatMolecular weight:523.32Sitagliptin phosphate hydrate
CAS:Formula:C16H15F6N5O·H3PO4·xH2OPurity:≥ 98.0% (anhydrous)Color and Shape:White to off-white powderMolecular weight:505.31Sitagliptin phosphate monohydrate
CAS:Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.Formula:C16H15F6N5O·H3PO4·H2OPurity:99.85% - 99.98%Color and Shape:White Or Almost White Crystalline PowderMolecular weight:523.33Sitagliptin Phosphate Monohydrate (Secondary Standards Traceable to USP)
CAS:Formula:C16H15F6N5OH3O4PH2OMolecular weight:407.3 : 98.0 : 18.0Sitagliptin phosphate monohydrate - Bio-X ™
CAS:<p>Sitagliptin is a drug that can be used to treat type 2 diabetes. This drug increases the production of an incretin hormone called glucagon-like peptide-1 (GLP-1) by stimulating the GLP-1 receptor. Sitagliptin is used in combination with metformin or a thiazolidinedione to improve glycemic control in patients with type 2 diabetes mellitus. Sitagliptin has been shown to improve postprandial blood glucose levels and reduce the risk of cardiovascular events. It also reduces the incidence of myocardial infarction and congestive heart failure in patients with type 2 diabetes who are already at high risk for these conditions.</p>Formula:C16H20F6N5O6PPurity:(%) Min. 95%Color and Shape:PowderMolecular weight:523.32 g/molSitagliptin phosphate monohydrate
CAS:<p>Sitagliptin phosphate monohydrate is a DPP-IV inhibitor that is used to treat type 2 diabetes mellitus. Sitagliptin decreases postprandial glucose levels and improves glycemic control. It binds to the enzyme DPP-IV, which breaks down peptides in the small intestine, inhibiting the breakdown of incretin hormones such as glucagon-like peptide 1 and glucose transporter type 2 (GLUT2). This leads to increased levels of GLP-1. Sitagliptin also has been shown to have an anti-diabetic effect by increasing insulin release from pancreatic beta cells.</p>Formula:C16H20F6N5O6PPurity:Min. 95%Color and Shape:White PowderMolecular weight:523.32 g/mol
![1,2,4-Triazolo[4,3-a]pyrazine,7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrah…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA00IBHW.jpg&w=3840&q=75)
