CAS 654671-77-9: Sitagliptin phosphate monohydrate
Description:Sitagliptin phosphate monohydrate is a pharmaceutical compound primarily used in the management of type 2 diabetes mellitus. It functions as a dipeptidyl peptidase-4 (DPP-4) inhibitor, which enhances the body's incretin levels, leading to increased insulin secretion and decreased glucagon levels in response to meals. This mechanism helps to lower blood glucose levels. The substance appears as a white to off-white crystalline powder and is soluble in water, which facilitates its absorption in the body. Its molecular formula includes elements such as carbon, hydrogen, nitrogen, oxygen, and phosphorus, reflecting its complex structure. Sitagliptin phosphate monohydrate is typically administered orally and is often prescribed in combination with other antidiabetic medications to improve glycemic control. As with any medication, it is essential to monitor for potential side effects, which may include gastrointestinal issues or allergic reactions. Overall, Sitagliptin phosphate monohydrate represents a significant advancement in diabetes treatment, offering a targeted approach to managing blood sugar levels.
Formula:C16H15F6N5O·H3O4P·H2O
InChI:InChI=1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4);1H2/t9-;;/m1../s1
InChI key:InChIKey=GQPYTJVDPQTBQC-KLQYNRQASA-N
SMILES:O=C(N1CC2=NN=C(N2CC1)C(F)(F)F)CC(N)CC3=CC(F)=C(F)C=C3F.O=P(O)(O)O.O
- Synonyms:
- (2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine dihydrogen phosphate monohydrate
- (3R)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one phosphate hydrate (1:1:1)
- 1,2,4-Triazolo[4,3-a]pyrazine, 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-, phosphate (1:1), monohydrate
- 1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)-, phosphate, hydrate (1:1:1)
- 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate monohydrate
- Sitagliptin Phosphate Monohydrate
- Sitagliptin phosephate monohydrate
- Sitagliptin phosphate hydrate
![1,2,4-Triazolo[4,3-a]pyrazine,7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrah…](https://static.cymitquimica.com/products/IN/thumb/DA00IBHW.jpg)
