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CAS 65472-88-0

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Naftifine

Description:
Naftifine is an antifungal agent primarily used in the treatment of dermatophyte infections, such as athlete's foot and ringworm. It belongs to the class of allylamines and works by inhibiting the enzyme squalene epoxidase, which is crucial for the biosynthesis of ergosterol, an essential component of fungal cell membranes. This disruption leads to increased cell membrane permeability and ultimately the death of the fungal cells. Naftifine is typically available in topical formulations, such as creams or gels, allowing for localized treatment with minimal systemic absorption. The compound is characterized by its lipophilic nature, which enhances its penetration into the skin and its effectiveness against various fungi. Additionally, Naftifine exhibits a favorable safety profile, with few reported side effects, making it a popular choice in dermatological practice. Its chemical structure includes a naphthalene ring, contributing to its unique properties and efficacy against fungal pathogens.
Formula:C21H21N
InChI:InChI=1S/C21H21N/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20/h2-15H,16-17H2,1H3/b11-8+
InChI key:InChIKey=OZGNYLLQHRPOBR-DHZHZOJOSA-N
SMILES:C(N(C/C=C/C1=CC=CC=C1)C)C=2C3=C(C=CC2)C=CC=C3
Synonyms:
  • (2E)-N-Methyl-N-(1-naphthylmethyl)-3-phenylprop-2-en-1-amine
  • (2E)-N-methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine
  • (2E)-N-methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine hydrochloride
  • (E)-N-Methyl-N-(3-phenyl-2-propenyl)-1-naphthalenemethanamine
  • 1-Naphthalenemethanamine, N-methyl-N-(3-phenyl-2-propenyl)-, (E)-
  • 1-Naphthalenemethanamine, N-methyl-N-[(2E)-3-phenyl-2-propenyl]-
  • 1-naphthalenemethanamine, N-methyl-N-[(2E)-3-phenyl-2-propen-1-yl]-
  • 65472-88-0
  • Exoderil
  • N-Methyl-N-(1-naphthylmethyl)-3-phenylpropen-1-amine
  • See more synonyms
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Found 3 products.
  • methyl[(naphthalen-1-yl)methyl](3-phenylprop-2-en-1-yl)amine
    Indagoo
    + Info

    methyl[(naphthalen-1-yl)methyl](3-phenylprop-2-en-1-yl)amine

    CAS:
    Formula:C21H21N
    Purity:98%
    Color and Shape:Liquid
    Molecular weight:287.3981

    Ref: IN-DA003SPI

    10mg
    159.00€
  • Naftifine
    Glentham
    + Info

    Naftifine

    CAS:
    Formula:C21H21N
    Molecular weight:287.40

    Ref: 7W-GP8297

    ne
    To inquire
  • (E)-Naftifine
    TRC
    + Info

    (E)-Naftifine

    CAS:
    <p>Applications (E)-Naftifine is an intermediate in synthesizing Naftifine N-Oxide (N213110), which is an impurity or metabolite of Naftifine Hydrochloride (N213100), an allylamine antifungal agent.<br>References Georgopoulos, A., et al.: Antimicrob. Ag. Chemother., 19, 386 (1981); Meingassner, J.C., et al.: J. Invest. Dermatol., 77, 444 (1981); Paltauf, F., et al.: Biochim Biophys. Acta, 712, 268 (1982); Aggarwal, D., et al.: J. Pharm. Pharmacol., 56, 1509 (2004)<br></p>
    Formula:C21H21N
    Color and Shape:Neat
    Molecular weight:287.40

    Ref: TR-N213310

    10mg
    123.00€
    100mg
    259.00€