CAS 65473-14-5
:Naftifine hydrochloride
Description:
Naftifine hydrochloride is an antifungal agent primarily used in the treatment of dermatophyte infections, such as athlete's foot and ringworm. It belongs to the class of allylamines and functions by inhibiting the enzyme squalene epoxidase, which is crucial in the biosynthesis of ergosterol, an essential component of fungal cell membranes. This disruption leads to the accumulation of toxic squalene and ultimately results in fungal cell death. Naftifine hydrochloride is typically administered topically, allowing for localized treatment with minimal systemic absorption. The compound is characterized by its white to off-white crystalline powder form, with a relatively low solubility in water but better solubility in organic solvents. Its pharmacokinetics indicate a prolonged duration of action, making it effective with once-daily applications. Safety profiles indicate that it is generally well-tolerated, with few side effects, although local irritation may occur in some patients. Overall, Naftifine hydrochloride is a valuable option in antifungal therapy, particularly for superficial skin infections.
Formula:C21H21N·ClH
InChI:InChI=1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
InChI key:InChIKey=OLUNPKFOFGZHRT-YGCVIUNWSA-N
SMILES:C(N(C/C=C/C1=CC=CC=C1)C)C=2C3=C(C=CC2)C=CC=C3.Cl
Synonyms:- (E)-N-Cinnamyl-N-methyl(1-naphthylmethyl)amine hydrochloride
- (E)-N-Cirmamyl-N-mcthyl(1一naphthylmethyl)amine hydrochloridc
- 1-Naphthalenemethanamine, N-methyl-N-(3-phenyl-2-propenyl)-, hydrochloride, (E)-
- 1-Naphthalenemethanamine, N-methyl-N-[(2E)-3-phenyl-2-propen-1-yl]-, hydrochloride (1:1)
- 1-Naphthalenemethanamine, N-methyl-N-[(2E)-3-phenyl-2-propenyl]-, hydrochloride
- Aw 105-843
- Exoderil
- Naftifine HCl
- Naftin
- Sn 105-843
- Naftifine hydrochloride
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Found 13 products.
Naftifine Hydrochloride
CAS:<p>Aromatic monoamines not elsewhere specified or included and their derivatives, salts therof</p>Formula:C21H21N·HClColor and Shape:White PowderMolecular weight:287.1674Naftifine hydrochloride
CAS:<p>Naftifine HCl: synthetic antifungal; inhibits squalene epoxidase, disrupting fungal cell sterol synthesis.</p>Formula:C21H22ClNPurity:98.75% - 99.84%Color and Shape:SolidMolecular weight:323.86Naftifine-d3 HCl
CAS:Formula:C21H18ND3·HClColor and Shape:White To Off-White SolidMolecular weight:290.43 36.46Naftifine Hydrochloride
CAS:Formula:C21H21N·HClPurity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:323.86Naftifine hydrochloride
CAS:Formula:C21H21N·HClPurity:≥ 99.0%Color and Shape:White to off-white powderMolecular weight:323.86Naftifine Hydrochloride
CAS:Controlled Product<p>Applications Antimycotic allylamine. An antifungal (topical) agent.<br>References Georgopoulos, A., et al.: Antimicrob. Ag. Chemother., 19, 386 (1981), Meingassner, J.C., et al.: J. Invest. Dermatol., 77, 444 (1981), Paltauf, F., et al.: Biochim Biophys. Acta, 712, 268 (1982), Aggarwal, D., et al.: J. Pharm. Pharmacol., 56, 1509 (2004),<br></p>Formula:C21H21N·ClHColor and Shape:NeatMolecular weight:323.86(E)-N-Methyl-N-(3-phenyl-2-propen-1-yl)-1-naphthalenemethanamine hydrochloride
CAS:<p>Naphthalene-1,3-diamine is an antifungal drug that belongs to a class of phenylenediamines. It is active against some bacteria and yeasts, including Candida albicans and Aspergillus niger. Naphthalene-1,3-diamine has been shown to have in vitro activity against mycological pathogens, such as Trichophyton mentagrophytes and Microsporum canis. The drug binds to the enzyme epoxidase in the fungal cell membrane. This binding inhibits the conversion of ergosterol to ergosta-4,6-diene which leads to increased membrane permeability and leakage of cytoplasmic contents. Naphthalene-1,3-diamine also inhibits human polymorphonuclear leukocytes (PMNL) chemotaxis by blocking phosphatidylserine externalization on PMNL membranes. In vitro studies show</p>Formula:C21H22ClNPurity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:323.86 g/mol
