CAS 6554-10-5

5'-O-(Triphenylmethyl)-uridine

Description:

5'-O-(Triphenylmethyl)-uridine, commonly referred to as TPM-uridine, is a modified nucleoside derivative of uridine. It features a triphenylmethyl (trityl) group attached to the 5' hydroxyl position of the uridine molecule, which enhances its stability and solubility in organic solvents. This modification is often utilized in biochemical and molecular biology applications, particularly in the synthesis of RNA and other nucleic acid derivatives. The trityl group serves as a protective group, preventing unwanted reactions during chemical manipulations. TPM-uridine is typically characterized by its ability to undergo selective deprotection under mild acidic conditions, allowing for the release of the active uridine moiety. Its structural characteristics contribute to its utility in various research applications, including studies on RNA structure and function, as well as in the development of nucleic acid-based therapeutics. Overall, 5'-O-(Triphenylmethyl)-uridine is a valuable compound in the field of nucleic acid chemistry, facilitating the exploration of RNA-related processes.

Formula: C₂₈H₂₆N₂O₆

InChI: InChI=1/C28H26N2O6/c31-23-16-17-30(27(34)29-23)26-25(33)24(32)22(36-26)18-35-28(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-17,22,24-26,32-33H,18H2,(H,29,31,34)

InChI key: InChIKey=YQHCGMPQZCIQPS-VNSJUHMKSA-N

SMILES: C(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C(=O)NC(=O)C=C2)(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5

Synonyms:

• 1-(5-O-tritylpentofuranosyl)pyrimidine-2,4(1H,3H)-dione
• 5-O-Trityluridine
• 5′-O-Triphenylmethyluridine
• NSC 97038
• Uridine, 5′-O-(triphenylmethyl)-
• Uridine, 5′-O-trityl-
• 5′-O-(Triphenylmethyl)uridine
• Trt-rU
• 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-((trityloxy)Methyl)tetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
• 5'-O-Trityl-D-uridine
• 5'-O-TRITYLURIDINE 98+%

5'-O-Trityluridine

CAS: 6554-10-5

Formula: C₂₈H₂₆N₂O₆

Color and Shape: Solid

Molecular weight: 486.5158

Ref: IN-DA00E9PT

5''-O-Trityluridine

CAS: 6554-10-5

Formula: C₂₈H₂₆N₂O₆

Molecular weight: 486.52

Ref: 7W-GN8245

5'-O-Trityluridine

CAS: 6554-10-5

5'-O-Trityluridine is a nucleoside analogue that has been prepared as an oriented, oxidized, hydrogenated, xylene derivative of uridine. It is composed of ribofuranoside and uridine. The orientation is controlled by the use of trityl groups on the 5' and 3' hydroxyl groups. The alkali metal salt isomers are analysed using HPLC and GC. This compound interacts with phosphotriesters and cyclic phosphodiesters.

Formula: C₂₈H₂₆N₂O₆

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 486.52 g/mol

Ref: 3D-NT06665

5’-O-Trityl Uridine

Controlled Product

CAS: 6554-10-5

Applications A protected potential anti-cancer and anti-viral agent.
References Lin, T-S., et al.: J. Med. Chem., 34, 693 (1991),

Formula: C₂₈H₂₆N₂O₆

Color and Shape: Neat

Molecular weight: 486.52

Ref: TR-T890500