CAS 65576-45-6

Asenapine

Description:

Asenapine is an atypical antipsychotic medication primarily used in the treatment of schizophrenia and bipolar disorder. It is classified as a dibenzodiazepine derivative and exhibits a complex pharmacological profile, acting as an antagonist at various neurotransmitter receptors, including serotonin (5-HT2A, 5-HT2C) and dopamine (D2) receptors. Asenapine is notable for its sublingual formulation, which allows for rapid absorption and onset of action. The substance is characterized by its relatively low bioavailability when taken orally due to extensive first-pass metabolism. Its chemical structure includes a fused ring system, contributing to its unique properties and receptor binding affinity. Common side effects associated with asenapine include sedation, weight gain, and extrapyramidal symptoms, although it is generally considered to have a lower risk of these effects compared to some other antipsychotics. Asenapine's efficacy and safety profile make it a valuable option in the management of certain psychiatric conditions, although careful monitoring is essential due to potential metabolic and neurological side effects.

Formula: C₁₇H₁₆ClNO

InChI: InChI=1/C17H16ClNO/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19/h2-8,14-15H,9-10H2,1H3/t14-,15-/m0/s1

InChI key: InChIKey=VSWBSWWIRNCQIJ-PTTDRDKLNA-N

SMILES: CN1C[C@]2([C@@](C=3C(OC=4C2=CC(Cl)=CC4)=CC=CC3)(C1)[H])[H]

Synonyms:

• (3aR,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
• (3aS,12bS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
• 1H-Dibenz(2,3:6,7)oxepino(4,5-c)pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, (3aR,12bR)-rel-
• 1H-Dibenz(2,3:6,7)oxepino(4,5-c)pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, trans-
• Alkepin
• Asenapine
• Asenapine [INN:BAN]
• Org 5222
• Saphris
• Sycrest
• Unii-Jkz19V908O
• rel-(3aR,12bR)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
• trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole
• ORG 5222;ORG-5222;ORG5222
• (3aS,12bS)-5-chloro-2-Methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole Maleate
• Einecs 265-829-4
• Asenapine USP/EP/BP
• trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:...
• Asenapine Impurity 2
• (3aR*,12bR*)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrolemaleate
• (3aR,12bR)-rel-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole

(±)-Asenapine

CAS: 65576-45-6

Formula: C₁₇H₁₆ClNO

Purity: %

Color and Shape: Solid

Molecular weight: 285.7680

Ref: IN-DA00E952

Asenapine

CAS: 65576-45-6

Asenapine

Purity: ≥98%

Molecular weight: 285.77g/mol

Ref: 54-BUP02364

Asenapine

CAS: 65576-45-6

Formula: C₁₇H₁₆ClNO

Molecular weight: 285.77

Ref: 7W-GP0267

Asenapine

CAS: 65576-45-6

Asenapine (Org 5222) is a 5-HT receptor, adrenergic receptor, and histamine receptor antagonist with antipsychotic properties for the treatment of schizophrenia

Formula: C₁₇H₁₆ClNO

Purity: 99.64%

Color and Shape: Coa

Molecular weight: 285.77

Ref: TM-T21360

Asenapine

Controlled Product

CAS: 65576-45-6

Applications Combined serotonin (5HT2) and dopamine (D2) receptor antagonist; structurally related to Mianserin. Antipsychotic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Meltzer, H., et al.: J. Pharmacol. Exp. Ther., 251, 238 (1989), Schotte, A., et al.: Brain Res., 631, 191 (1993), Andree, B., et al.: Psychopharmacology, 131, 339 (1997), Richelson, E., et al.: Life Sci., 68, 29 (2000),

Formula: C₁₇H₁₆ClNO

Color and Shape: Neat

Molecular weight: 285.77

Ref: TR-A788000

((10S,11S)-8-Chloro-11-((methylamino)methyl)-10,11-dihydrodibenzo[b,f]oxepin-10-yl)methanol

Controlled Product

CAS: 1357194-69-4, 65576-45-6

Formula: C₁₇H₁₈ClNO₂

Color and Shape: Neat

Molecular weight: 607.567

Ref: TR-D356565

Asenapine-d7 (Major)

Controlled Product

CAS: 65576-45-6

Applications Labelled Asenapine. Asenapine is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist; structurally related to Mianserin. Antipsychotic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Meltzer, H. et al.: J. Pharmacol. Exp. Ther., 251, 238 (1989); Schotte, A. et al.: Brain Res., 631, 191 (1993); Andree, B. et al.: Psychopharmacology, 131, 339 (1997); Richelson, E. et al.: Life Sci., 68, 29 (2000);

Formula: C₁₇D₇H₉ClNO

Color and Shape: Neat

Molecular weight: 292.81

Ref: TR-A788003

Asenapine

Controlled Product

CAS: 65576-45-6

Inhibits dopamine, serotonin and adrenergic receptors

Formula: C₁₇H₁₆ClNO

Purity: Min. 95%

Molecular weight: 285.77 g/mol

Ref: 3D-FA17998