CAS 656247-18-6

Nintedanib esylate

Description:

Nintedanib esylate is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of cancer, particularly non-small cell lung cancer and idiopathic pulmonary fibrosis. It functions by inhibiting multiple receptor tyrosine kinases involved in tumor growth and angiogenesis, including VEGFR, PDGFR, and FGFR. The compound is characterized by its complex chemical structure, which includes a bicyclic core and various functional groups that contribute to its pharmacological activity. Nintedanib esylate is typically administered orally and is known for its moderate to high bioavailability. It is also associated with a range of side effects, including gastrointestinal disturbances and liver enzyme elevations. The substance is soluble in organic solvents and exhibits stability under standard storage conditions. Its development has been guided by extensive clinical trials, demonstrating its efficacy in slowing disease progression in targeted patient populations. As with any pharmaceutical agent, its use should be closely monitored by healthcare professionals to manage potential adverse effects and interactions with other medications.

Formula: C₃₁H₃₃N₅O₄·C₂H₆O₃S

InChI: InChI=1S/C31H33N5O4.C2H6O3S/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38;1-2-6(3,4)5/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38);2H2,1H3,(H,3,4,5)/b29-28-;

InChI key: InChIKey=MMMVNAGRWOJNMW-FJBFXRHMSA-N

SMILES: C(\NC1=CC=C(N(C(CN2CCN(C)CC2)=O)C)C=C1)(=C\3/C=4C(NC3=O)=CC(C(OC)=O)=CC4)/C5=CC=CC=C5.S(CC)(=O)(=O)O

Synonyms:

• (3Z)-2,3-Dihydro-3-[[[4-[Methyl[2-(4-Methyl-1-piperazinyl)acetyl]aMino]phenyl]aMino]phenylMethylene]-2-oxo-1H-indole-6-carboxylic acid Methyl ester ethanesulfonate
• 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-, monoethanesulfonate
• 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-, ethanesulfonate (1:1)
• Nintedanib Esylate
• Nintedanib ethanesulfonate
• Ofev
• Nintedanib esylate. Nintedanib ethanesulfonate salt
• Nintedanib ethanesulfonate salt
• BIBF1120 ethanesulfonate salt
• Nintedanib
• Nintedanib Ethanesulfonate (Intedanib Ethanesulfonate)
• Nintedanib(ethanesulfonic acid)
• Brand name OFEV. Vargatef.
• BIBF 1120 BIBF-1120
• Nintedani
• Trinidad Neeb esylate
• Trinidad Neeb ethanesulfonate
• BIBF1120; BIBF 1120 BIBF-1120; NINTEDANIB ESYLATE. NINTEDANIB ETHANESULFONATE SALT; INTEDANIB; BRAND NAME OFEV. VARGATEF.
• BIBF-1120 esylate
• BIBF 1120 esylate
• (Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene
• Intedanib ethanesulfonate
• BIBF1120/nintedanib ethanesulfonate salt
• (Z)-methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate

(3Z)-2,3-Dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1h-indole-6-carboxylic acid methyl ester ethanesulfonate

CAS: 656247-18-6

Formula: C₃₃H₃₉N₅O₇S

Purity: 98%

Color and Shape: Solid

Molecular weight: 649.7571

Ref: IN-DA0039OF

Nintedanib esylate

CAS: 656247-18-6

Nintedanib esylate

Purity: ≥98%

Molecular weight: 649.76g/mol

Ref: 54-BUP15454

Nintedanib Ethanesulfonate

CAS: 656247-18-6

Formula: C₃₁H₃₃N₅O₄·C₂H₆O₃S

Molecular weight: 539.64 110.13

Ref: 4Z-N-066001

Nintedanib Esylate

CAS: 656247-18-6

Nintedanib Esylate

Purity: 98%

Molecular weight: 649.77g/mol

Ref: 54-OR1029501

Nintedanib Esilate

Controlled Product

CAS: 656247-18-6

Formula: C₃₁H₃₃N₅O₄·C₂H₆O₃S

Color and Shape: Neat

Molecular weight: 649.76

Ref: 86-MM3704.00

Nintedanib esylate

CAS: 656247-18-6

Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β

Formula: C₃₁H₃₃N₅O₄·C₂H₆O₃S

Purity: 99.43% - 99.98%

Color and Shape: Solid

Molecular weight: 649.76

Ref: TM-T5001

Nintedanib Esylate

CAS: 656247-18-6

Formula: C₃₁H₃₃N₅O₄C₂H₆O₃S

Molecular weight: 539.64 : 110.13

Ref: ST-EA-CP-N24014

Nintedanib Esylate

CAS: 656247-18-6

Formula: C₃₁H₃₃N₅O₄·C₂H₆O₃S

Color and Shape: Light Yellow

Molecular weight: 649.76

Ref: TR-N478290

Nintedanib ethanesulfonate

CAS: 656247-18-6

Used for treatment of idiopathic pulmonary fibrosis

Formula: C₃₁H₃₃N₅O₄•C₂H₆O₃S

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 649.76 g/mol

Ref: 3D-FD71497