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CAS 656247-18-6

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Nintedanib esylate

Description:
Nintedanib esylate is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of cancer, particularly non-small cell lung cancer and idiopathic pulmonary fibrosis. It functions by inhibiting multiple receptor tyrosine kinases involved in tumor growth and angiogenesis, including VEGFR, PDGFR, and FGFR. The compound is characterized by its complex chemical structure, which includes a bicyclic core and various functional groups that contribute to its pharmacological activity. Nintedanib esylate is typically administered orally and is known for its moderate to high bioavailability. It is also associated with a range of side effects, including gastrointestinal disturbances and liver enzyme elevations. The substance is soluble in organic solvents and exhibits stability under standard storage conditions. Its development has been guided by extensive clinical trials, demonstrating its efficacy in slowing disease progression in targeted patient populations. As with any pharmaceutical agent, its use should be closely monitored by healthcare professionals to manage potential adverse effects and interactions with other medications.
Formula:C31H33N5O4·C2H6O3S
InChI:InChI=1S/C31H33N5O4.C2H6O3S/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38;1-2-6(3,4)5/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38);2H2,1H3,(H,3,4,5)/b29-28-;
InChI key:InChIKey=MMMVNAGRWOJNMW-FJBFXRHMSA-N
SMILES:C(\NC1=CC=C(N(C(CN2CCN(C)CC2)=O)C)C=C1)(=C\3/C=4C(NC3=O)=CC(C(OC)=O)=CC4)/C5=CC=CC=C5.S(CC)(=O)(=O)O
Synonyms:
  • (3Z)-2,3-Dihydro-3-[[[4-[Methyl[2-(4-Methyl-1-piperazinyl)acetyl]aMino]phenyl]aMino]phenylMethylene]-2-oxo-1H-indole-6-carboxylic acid Methyl ester ethanesulfonate
  • 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-, monoethanesulfonate
  • 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-, ethanesulfonate (1:1)
  • Nintedanib Esylate
  • Nintedanib ethanesulfonate
  • Ofev
  • Nintedanib esylate. Nintedanib ethanesulfonate salt
  • Nintedanib ethanesulfonate salt
  • BIBF1120 ethanesulfonate salt
  • Nintedanib
  • See more synonyms
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Found 9 products.