CAS 656820-32-5

Reversine

Description:

Reversine, with the CAS number 656820-32-5, is a small molecule that has garnered attention in the field of biomedical research, particularly for its potential applications in regenerative medicine and stem cell biology. It is known to act as a selective inhibitor of certain kinases, which play crucial roles in various cellular processes, including proliferation and differentiation. Reversine has been studied for its ability to induce the dedifferentiation of mature cells, allowing them to revert to a more pluripotent state, which is significant for tissue engineering and regenerative therapies. The compound exhibits a relatively low molecular weight and is characterized by its specific chemical structure, which includes a purine-like scaffold. Its mechanism of action involves modulation of signaling pathways that are critical for cell fate decisions. While promising, further research is necessary to fully understand its effects, optimize its use, and evaluate its safety and efficacy in clinical applications.

Formula: C₂₁H₂₇N₇O

InChI: InChI=1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27)

InChI key: InChIKey=ZFLJHSQHILSNCM-UHFFFAOYSA-N

SMILES: N(C1=C2C(=NC(NC3=CC=C(C=C3)N4CCOCC4)=N1)N=CN2)C5CCCCC5

Synonyms:

• 1H-Purine-2,6-diamine, N⁶-cyclohexyl-N²-[4-(4-morpholinyl)phenyl]-
• 1H-purine-2,6-diamine, N~6~-cyclohexyl-N~2~-[4-(4-morpholinyl)phenyl]-
• 2-(4-Morpholinoanilino)-6-Cyclohexylaminopurine
• 9H-Purine-2,6-diamine, N⁶-cyclohexyl-N²-[4-(4-morpholinyl)phenyl]-
• N⁶-Cyclohexyl-N²-[4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine
• N~6~-cyclohexyl-N~2~-[4-(morpholin-4-yl)phenyl]-1H-purine-2,6-diamine
• Reversine
• 9H-Purine-2,6-diamine, N6-cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-
• 1H-Purine-2,6-diamine, N6-cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-
• N6-Cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine

Reversine

CAS: 656820-32-5

Formula: C₂₁H₂₇N₇O

Purity: ≥ 98%

Color and Shape: White or off-white solid

Molecular weight: 393.49

Ref: 7W-GL5363

Reversine

CAS: 656820-32-5

Reversine

Purity: ≥98%

Molecular weight: 393.49g/mol

Ref: 54-BUP05411

Reversine

CAS: 656820-32-5

Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).

Formula: C₂₁H₂₇N₇O

Purity: 98% - 98.42%

Color and Shape: Solid

Molecular weight: 393.49

Ref: TM-T1825

REVERSINE

CAS: 656820-32-5

Formula: C₂₁H₂₇N₇O

Purity: 98%

Molecular weight: 393.495

Ref: 10-F468371

Reversine

Controlled Product

CAS: 656820-32-5

Applications Reversine acts as a potent human A3 adenosine receptor antagonist and pan-aurora A/B/C kinase inhibitor. Used for stem cell differentiation.
References Park, J. Biochem. Biophys. Res. Comm., 446, 30 (2014); Kim, M. et al.: Biochem. Biophys. Res. Comm., 445, 255 (2014);

Formula: C₂₁H₂₇N₇O

Color and Shape: Neat

Molecular weight: 393.485

Ref: TR-R279900

Reversine

CAS: 656820-32-5

Inhibitor of Aurora kinases

Purity: Min. 95%

Ref: 3D-FR137712