CAS 65686-11-5

8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-ol

Description:

8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-ol is a chemical compound belonging to the class of benzodiazepines, which are known for their psychoactive properties. This particular compound features a triazole ring fused to a benzodiazepine structure, contributing to its unique pharmacological profile. The presence of chlorine substituents enhances its lipophilicity and may influence its biological activity. The hydroxyl group at the 4-position of the benzodiazepine core can participate in hydrogen bonding, potentially affecting its interaction with biological targets, such as GABA receptors. This compound may exhibit anxiolytic, sedative, or anticonvulsant effects, typical of many benzodiazepines, although specific pharmacological data would be necessary to confirm its activity. Additionally, its molecular structure suggests potential for further derivatization, which could lead to the development of novel therapeutic agents. As with many compounds in this class, safety and efficacy profiles would need to be thoroughly evaluated in clinical settings.

Formula: C₁₇H₁₂Cl₂N₄O

InChI: InChI=1/C17H12Cl2N4O/c1-9-21-22-16-17(24)20-15(11-4-2-3-5-13(11)19)12-8-10(18)6-7-14(12)23(9)16/h2-8,17,24H,1H3

SMILES: Cc1nnc2C(N=C(c3ccccc3Cl)c3cc(ccc3n12)Cl)O

Synonyms:

• 4H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepin-4-ol, 8-chloro-6-(2-chlorophenyl)-1-methyl-

4-Hydroxy Triazolam

Controlled Product

CAS: 65686-11-5

Stability Light Sensitive
Applications A metabolite of Triazolam (T767380).
References Gall, M., et al.: J. Med. Chem., 21, 1290 (1978), Jones, H., et al.: Drug Metab. Dispos., 32, 973 (2004), Hallifax, D., et al.: Drug Metab. Dispos., 33, 1852 (2005).

Formula: C₁₇H₁₂Cl₂N₄O

Color and Shape: Neat

Molecular weight: 359.21

Ref: TR-H971330

4-Hydroxy-triazolam

Controlled Product

CAS: 65686-11-5

4-Hydroxy-triazolam is an analog of triazolam that has shown promising anticancer activity. It has been found to induce apoptosis in cancer cells and inhibit the growth of tumors. This compound is excreted primarily in urine and has been studied extensively as a potential inhibitor of kinases and elastase, both of which are involved in cancer progression. 4-Hydroxy-triazolam has also been investigated for its potential use as an anticancer drug in Chinese medicine. Although it shares some structural similarities with etomidate, a general anesthetic, it has distinct pharmacological properties that make it a promising candidate for further study as a cancer therapy.

Formula: C₁₇H₁₂Cl₂N₄O

Purity: Min. 95%

Molecular weight: 359.2 g/mol

Ref: 3D-QCA68611