CAS 65886-71-7

Fazarabine

Description:

Fazarabine, with the CAS number 65886-71-7, is a synthetic nucleoside analog that exhibits antineoplastic properties, primarily used in the treatment of certain types of cancer. It is structurally related to purine nucleosides and functions by interfering with DNA synthesis and repair, ultimately leading to cell death in rapidly dividing cancer cells. Fazarabine is known for its ability to inhibit ribonucleotide reductase, an enzyme crucial for DNA synthesis, thereby disrupting the proliferation of malignant cells. The compound is typically administered intravenously and has been studied in various clinical settings, particularly for hematological malignancies. Its pharmacokinetics involve metabolism primarily in the liver, and it may exhibit a range of side effects, including myelosuppression and gastrointestinal disturbances. As with many chemotherapeutic agents, careful monitoring is essential to manage potential toxicities and ensure therapeutic efficacy. Overall, Fazarabine represents a significant tool in the oncological pharmacotherapy arsenal, although its use may be limited by its side effect profile and the emergence of resistance in some cancer types.

Formula: C₈H₁₂N₄O₅

InChI: InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5+,6-/m1/s1

InChI key: InChIKey=NMUSYJAQQFHJEW-ARQDHWQXSA-N

SMILES: O[C@@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)N=C2

Synonyms:

• 1,3,5-Triazin-2(1H)-one, 4-amino-1-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-
• 1,3,5-triazin-2(1H)-one, 4-amino-1-beta-D-arabinofuranosyl-
• 1-.beta.-D-Arabinofuranosyl-5-azacytosine
• 1-β-<span class="text-smallcaps">D</span>-Arabinofuranosyl-5-azacytosine
• 1b-D-Arabinofuranosyl-5-azacytosine
• 4-Amino-1-(beta-D-arabinofuranosyl)-1,3,5-triazin-2(1H)-one
• 4-Amino-1-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-1,3,5-triazin-2(1H)-one
• 4-Amino-1b-D-arabinofuranosyl-s-triazin-2(1H)-one
• 5-Aza-1-arabinosylcytosine
• 5-Azacytosine arabinoside
• 65886-71-7
• Kymarabine
• NSC 281272
• ara-AC
• 1,3,5-Triazin-2(1H)-one, 4-amino-1-β-D-arabinofuranosyl-
• 4-Amino-1-β-D-arabinofuranosyl-1,3,5-triazin-2(1H)-one

Azacitidine Impurity 17

CAS: 65886-71-7

Formula: C₈H₁₂N₄O₅

Color and Shape: Off-White Solid

Molecular weight: 244.21

Ref: 4Z-A-8124

Fazarabine

CAS: 65886-71-7

Fazarabine is a nucleoside analog that has been shown to be a potent inhibitor of the enzyme fyn tyrosine kinase and to have cytotoxic effects on human leukemia HL-60 cells. The chemical stability of fazarabine has been demonstrated in methyltransferase inhibition studies. Fazarabine is also an anti-cancer compound with selective toxicity towards colorectal adenocarcinoma cells. Fazarabine inhibits cell proliferation by inhibiting protein synthesis, which may be due to its ability to act as a DNA template, or its receptor activity. Fazarabine also has immunosuppressive properties and can be used for the treatment of autoimmune diseases such as rheumatoid arthritis, Crohn's disease, and psoriasis.

Formula: C₈H₁₂N₄O₅

Purity: Min. 95%

Molecular weight: 244.2 g/mol

Ref: 3D-FF157115

Azacitidine Impurity 17

CAS: 65886-71-7

Formula: C₈H₁₂N₄O₅

Molecular weight: 244.21

Ref: ST-EA-CP-A35055

Fazarabine

CAS: 65886-71-7

Fazarabine, an oral pyrimidine analogue, mimics cytidine with arabinose, disrupts DNA synthesis, causing tumor cell death.

Formula: C₈H₁₂N₄O₅

Color and Shape: Solid

Molecular weight: 244.2

Ref: TM-T68917