CAS 65891-87-4

Ch282-5

CAS: 65891-87-4

Ch282-5, an orally active inhibitor targeting the Bcl-2 protein, promotes mitochondria-dependent apoptosis (Apoptosis) by disrupting mitophagy and the mTOR pathway. It demonstrates antiproliferative effects on colorectal cancer cells, effective both in vitro and in vivo, while also inhibiting metastasis. Further, Ch282-5 augments Oxaliplatin-induced autophagy (Autophagy) by downregulating Mcl-1 protein and raising platelet count, which helps mitigate the adverse effects of Navitoclax.

Formula: C₃₄H₃₄N₂Na₂O₁₄S₂

Color and Shape: Solid

Molecular weight: 804.75

Ref: TM-T200076