CAS 65899-73-2

Tioconazole

Description:

Tioconazole is an antifungal agent primarily used in the treatment of various fungal infections, particularly those caused by dermatophytes and yeast. It belongs to the imidazole class of antifungals and functions by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes, thereby disrupting their integrity and function. Tioconazole is typically available in topical formulations, such as creams and ointments, and is often used for conditions like athlete's foot, ringworm, and vaginal yeast infections. The substance is characterized by its relatively low solubility in water, which enhances its effectiveness when applied directly to affected areas. Tioconazole exhibits a broad spectrum of activity against various fungi, making it a versatile option in antifungal therapy. Additionally, it has a favorable safety profile, with minimal systemic absorption when used topically, resulting in fewer side effects compared to systemic antifungal treatments. As with any medication, it is essential to follow usage guidelines and consult healthcare professionals for appropriate indications and potential interactions.

Formula: C₁₆H₁₃Cl₃N₂OS

InChI: InChI=1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2

InChI key: InChIKey=QXHHHPZILQDDPS-UHFFFAOYSA-N

SMILES: C(CN1C=CN=C1)(OCC2=C(Cl)SC=C2)C3=C(Cl)C=C(Cl)C=C3

Synonyms:

• 1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl) ethyl]-1H-imidazole
• 1-[2-[(2-Chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)-ethyl]imidazole
• 1-{2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
• 1H-Imidazole, 1-[2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-
• Fungibacid
• Gyno-Trosyd
• New Straitus U
• Tioconazol
• Trosyd
• Trosyl
• Vagistat
• Vagistat 1
• Zoniden
• Tioconazole

Tioconazole

CAS: 65899-73-2

Color and Shape: Neat

Ref: 61-FOR1307.00

Tioconazole

CAS: 65899-73-2

Tioconazole

Formula: C₁₆H₁₃Cl₃N₂OS

Purity: 99.6%

Color and Shape: White

Molecular weight: 385.98142

Ref: 47-645

TIOCONAZOLE FOR SYSTEM SUITABILITY CRS

CAS: 65899-73-2

TIOCONAZOLE FOR SYSTEM SUITABILITY CRS

Formula: C₁₆H₁₃Cl₃N₂OS

Color and Shape: Crystalline Powder. White. Powder.

Molecular weight: 387.7112

Ref: 41-Y0000282

Tioconazole impurity standard

CAS: 65899-73-2

Tioconazole impurity standard

Color and Shape: White

Ref: 47-687

Tioconazole

CAS: 65899-73-2

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₆H₁₃Cl₃N₂OS

Color and Shape: Powder

Molecular weight: 385.98142

Ref: 45-1667439

1-{2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole

CAS: 65899-73-2

Formula: C₁₆H₁₃Cl₃N₂OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 387.7112

Ref: IN-DA00IBJE

Tioconazole

CAS: 65899-73-2

Tioconazole (Vagistat) is a synthetic imidazole derivative, inhibits cell wall synthesis by inhibiting the biosynthesis of ergosterol or other sterols.

Formula: C₁₆H₁₃Cl₃N₂OS

Purity: 99.57%

Color and Shape: Solid

Molecular weight: 387.71

Ref: TM-T0146

Tioconazole

CAS: 65899-73-2

Tioconazole

Purity: 98%

Molecular weight: 387.72g/mol

Ref: 54-OR1029498

Tioconazole

CAS: 65899-73-2

Tioconazole

Purity: ≥98%

Molecular weight: 387.71g/mol

Ref: 54-BUP18684

Tioconazole, USP grade

CAS: 65899-73-2

Formula: C₁₆H₁₃Cl₃N₂OS

Molecular weight: 387.71

Ref: 7W-GP8783

Tioconazole, Ph. Eur. grade

CAS: 65899-73-2

Formula: C₁₆H₁₃Cl₃N₂OS

Purity: ≤ 0.1%

Color and Shape: White to almost white powder

Molecular weight: 387.71

Ref: 7W-GP5512

Tioconazole

CAS: 65899-73-2

Formula: C₁₆H₁₃Cl₃N₂OS

Purity: ≥ 98.0% (dried basis)

Color and Shape: White or almost white powder or crystals

Molecular weight: 387.71

Ref: 7W-GA0099

Tioconazole

CAS: 65899-73-2

Formula: C₁₆H₁₃Cl₃N₂OS

Color and Shape: Neat

Molecular weight: 387.71

Ref: 86-MM1307.00

Tioconazole

CAS: 65899-73-2

Formula: C₁₆H₁₃Cl₃N₂OS

Molecular weight: 387.71

Ref: 4Z-T-110004

Tioconazole

Controlled Product

CAS: 65899-73-2

Applications Tioconazole is an antifungal that is more active than Fluconazole (F421000) or Voriconazole (V760000) against Candida glabrata mutant strains. Antifungal (topical).
References Jevons, S., et al.: Antimicrob. Agents Chemother., 15, 597 (1979), Clayton, Y.M., et al.: Clin. Exp. Dermatol., 7, 543 (1982), Marriott, M.S., et al.: Dermatologica, 166, 1 (1983),

Formula: C₁₆H₁₃Cl₃N₂OS

Color and Shape: White

Molecular weight: 387.71

Ref: TR-T444680

TIOCONAZOLE

CAS: 65899-73-2

Purity: ≥98%

Molecular weight: 387.7000122

Ref: 10-F811938

Tioconazole

CAS: 65899-73-2

Tioconazole is an antifungal agent, which is a synthetic derivative of imidazole with broad-spectrum activity against fungi. This compound is chemically synthesized through complex organic reactions to enhance its antimycotic efficacy. Tioconazole functions by inhibiting the synthesis of ergosterol, an essential component of the fungal cell membrane. By disrupting the ergosterol biosynthesis pathway, tioconazole destabilizes the fungal cell membrane, leading to increased permeability and eventual cell death.

Formula: C₁₆H₁₃Cl₃N₂OS

Purity: Min. 95%

Molecular weight: 387.71 g/mol

Ref: 3D-QCA89973