CAS 65934-74-9

5-Amino-2-methylbenzotrifluoride

Description:

5-Amino-2-methylbenzotrifluoride, with the CAS number 65934-74-9, is an organic compound characterized by the presence of an amino group (-NH2) and a trifluoromethyl group (-CF3) attached to a methyl-substituted benzene ring. This compound typically appears as a colorless to pale yellow liquid or solid, depending on its physical state at room temperature. It is known for its aromatic properties, which contribute to its stability and reactivity. The trifluoromethyl group enhances its lipophilicity and can influence its biological activity, making it of interest in various chemical applications, including pharmaceuticals and agrochemicals. The amino group can participate in hydrogen bonding, affecting solubility and reactivity in different solvents. Additionally, the compound may exhibit moderate toxicity, necessitating careful handling and appropriate safety measures during use. Overall, 5-Amino-2-methylbenzotrifluoride is a versatile compound with significant implications in synthetic organic chemistry.

Formula: C₆H₁₀F₄O

InChI: InChI=1/C6H10F4O/c1-5(2,3)11-6(9,10)4(7)8/h4H,1-3H3

InChI key: JBCDCYFEJQHTTA-UHFFFAOYSA-N

SMILES: CC(C)(C)OC(C(F)F)(F)F

Synonyms:

• 4-Methyl-3-(trifluoromethyl)aniline
• 3-Trifluoromethyl-p-toluidine
• 3-(Trifluoromethyl)-4-methylaniline
• 4-Methyl-5-Trifluoromethylaniline
• Tert-Butyl 1,1,2,2-Tetrafluoroethyl Ether

4-Methyl-3-(trifluoromethyl)aniline

CAS: 65934-74-9

Formula: C₈H₈F₃N

Purity: >98.0%(GC)(T)

Color and Shape: Colorless to Yellow to Orange clear liquid

Molecular weight: 175.15

Ref: 3B-M2659

4-Methyl-3-(trifluoromethyl)aniline

CAS: 65934-74-9

Formula: C₈H₈F₃N

Purity: 98%

Color and Shape: Liquid

Molecular weight: 175.154

Ref: 10-F010687

5-Amino-2-methylbenzotrifluoride

CAS: 65934-74-9

5-Amino-2-methylbenzotrifluoride

Formula: C₈H₈F₃N

Purity: 98%

Color and Shape: Liquid

Molecular weight: 175.15102

Ref: 54-PC0440

4-Methyl-3-(trifluoromethyl)aniline

CAS: 65934-74-9

Formula: C₈H₈F₃N

Purity: 98%

Color and Shape: Liquid

Molecular weight: 175.1510

Ref: IN-DA003LQH

5-Amino-2-methylbenzotrifluoride

Controlled Product

CAS: 65934-74-9

Applications 5-Amino-2-methylbenzotrifluoride is used to prepare azoles as inhibitors of VEGF receptors 1 and 2 with high intestinal permeability. It can also be used to prepare curcumin analogs conjugated with antiandrogens.
References Kiselyov, A., et al.: Bioorg. Med. Chem. Lett., 17, 1369 (2007); Shi, Q., et al.: Bioorg. Med. Chem., 20, 4020 (2012)

Formula: C₈H₈F₃N

Color and Shape: Neat

Molecular weight: 175.15

Ref: TR-A615240

4-Methyl-3-(trifluoromethyl)aniline

CAS: 65934-74-9

4-Methyl-3-(trifluoromethyl)aniline

Formula: C₈H₈F₃N

Purity: 98%

Molecular weight: 175.15

Ref: IN-DG11128