CAS 65988-71-8

Ganglioside GD2

Description:

Ganglioside GD2 is a glycosphingolipid, a type of molecule that plays a crucial role in cell membrane structure and function. It is primarily found in the nervous system and is particularly abundant in neuroectodermal tissues. GD2 is characterized by its complex carbohydrate structure, which includes a sialic acid residue, contributing to its negative charge and involvement in cell signaling and recognition processes. This ganglioside is known for its role in cell adhesion, differentiation, and proliferation, and it is often overexpressed in certain tumors, making it a target for cancer immunotherapy. GD2 is also involved in various biological processes, including neuronal development and immune responses. Its presence in the tumor microenvironment has led to the exploration of GD2-targeted therapies, such as monoclonal antibodies, for treating cancers like neuroblastoma and melanoma. Overall, GD2 serves as a significant biomarker in oncology and neuroscience, highlighting its importance in both health and disease.

Formula: Unspecified

InChI: InChI=1/C72H126N4O34/c1-6-8-10-12-14-16-17-18-19-21-22-24-26-28-42(85)41(76-50(89)29-27-25-23-20-15-13-11-9-7-2)37-101-67-59(95)58(94)61(48(35-80)103-67)105-68-60(96)65(62(49(36-81)104-68)106-66-53(75-40(5)84)57(93)55(91)46(33-78)102-66)110-72(70(99)100)31-44(87)52(74-39(4)83)64(109-72)56(92)47(34-79)107-71(69(97)98)30-43(86)51(73-38(3)82)63(108-71)54(90)45(88)32-77/h26,28,41-49,51-68,77-81,85-88,90-96H,6-25,27,29-37H2,1-5H3,(H,73,82)(H,74,83)(H,75,84)(H,76,89)(H,97,98)(H,99,100)/b28-26+/t41-,42+,43-,44-,45+,46+,47+,48+,49+,51+,52+,53+,54+,55-,56+,57+,58+,59+,60+,61+,62-,63?,64?,65+,66-,67+,68-,71+,72-/m0/s1

Synonyms:

• 65988-71-8
• Disialoganglioside GD₂
• G_D2
• Ganglioside G_D2
• Ganglioside GD2
• Disialoganglioside GD2
• GD2

Disialoganglioside-GD2

CAS: 65988-71-8

Ref: 7W-GL5116

Disialoganglioside GD2 (bovine)

CAS: 65988-71-8

Formula: Unspecified

Purity: >98%

Color and Shape: Solid

Ref: 48-56-1115

GD2-Ganglioside

CAS: 65988-71-8

GD2 (shown as sodium salt) has a core trisaccharide structure (GalNAc-b-1,4-Gal-b-1,4-Glc) with its two sialic acids linked b-2,3/b-2,8 to the inner galactose residue and ceramide linked to position 1 on the reducing terminal glucose residue. GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 is overexpressed in a number of tumors, including: neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, it has been found in low concentrations on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state), and tumor-initiating capabilities.  It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).

Formula: C₇₈H₁₃₈N₄O₃₄·xNa

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 1,675.94 g/mol

Ref: 3D-OG06830