CAS 66-28-4

Strophanthidin

Description:

Strophanthidin is a cardiac glycoside derived from the seeds of the Strophanthus genus of plants, particularly Strophanthus gratus. It is known for its ability to inhibit the Na+/K+ ATPase enzyme, which leads to increased intracellular sodium and calcium concentrations, ultimately enhancing cardiac contractility. Strophanthidin exhibits a structure characterized by a steroid nucleus with a lactone ring, contributing to its biological activity. It is typically used in pharmacological research and has historical significance in the treatment of heart conditions, although its clinical use has diminished due to the availability of safer alternatives. The compound is soluble in organic solvents but has limited solubility in water. Strophanthidin can exhibit toxic effects at higher concentrations, necessitating careful handling and dosage regulation. Its pharmacokinetics and dynamics are influenced by various factors, including its interaction with other medications and its metabolic pathways. As with all cardiac glycosides, monitoring is essential to avoid adverse effects, particularly in patients with underlying health conditions.

Formula: C₂₃H₃₂O₆

InChI: InChI=1/C23H32O6/c1-20-6-3-17-18(4-8-22(27)11-15(25)2-7-21(17,22)13-24)23(20,28)9-5-16(20)14-10-19(26)29-12-14/h10,13,15-18,25,27-28H,2-9,11-12H2,1H3/t15-,16?,17?,18?,20+,21-,22-,23-/m0/s1

InChI key: InChIKey=ODJLBQGVINUMMR-HZXDTFASSA-N

SMILES: C(=O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(CC3)[C@H](CC4)C5=CC(=O)OC5)(CC[C@]1(O)C[C@@H](O)CC2)[H])[H]

Synonyms:

• (3Beta,5Beta)-3,5,14-Trihydroxy-19-Oxocard-20(22)-Enolide
• (3Beta,5Beta,8Xi,9Xi,17Xi)-3,5,14-Trihydroxy-19-Oxocard-20(22)-Enolide
• (3β,5β)-3,5,14-Trihydroxy-19-oxocard-20(22)-enolide
• 3,5,14-Trihydroxy-19-Oxocard-20(22)-Enolide
• 5β-Card-20(22)-enolide, 3β,5,14-trihydroxy-19-oxo-
• Apocymarin
• Card-20(22)-enolide, 3,5,14-trihydroxy-19-oxo-, (3β,5β)-
• Convallatoxigenin
• Corchorin
• Corchoside A aglycon
• Corchsularin
• Erysimupicrone
• Erysimupikron
• NSC 86078
• Strophanthidin K
• Strophanthidine
• k-Strophanthidin
• Strophanthidin
• (3S,5S,8R,9S,10S,13R,14S,17R)-3,5,14-trihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde
• (3S,5S,8R,9S,10S,13R,14S,17R)-3,5,14-trihydroxy-17-(5-keto-2H-furan-3-yl)-13-methyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde
• Corcholin
• Strophantidin
• 3,5,14-trihydroxy-19-oxo-,(3-beta,5-beta)-card-20(22)-enolid
• 19-oxo-cardogenen-(20:22)-triol-(3-beta,5,14)
• 20(22)-cardenolide
• 3β,5,14-Trihydroxy-19-oxo-5β,20(22)-cardenolide, Cymarigenen, K-Strophanthidin
• Corchotoxin
• 3-beta,5,14-trioxy-19-oxo-digen-(20:22)-olid
• 3β5,14-Trihydroxy-19-oxo-5β20(22)-cardenolide
• CYMARIGENEN
• antibioticxs-89
• corchorgenin
• corchosideaaglycon
• 5-beta-hydroxy-19-oxodigitoxigenin
• cynotoxin
• 3-beta,5,14-trioxy-19-oxo-carden-(20:22)-olid
• 3-beta,5,14-trihydroxy-19-oxo-5-beta-card-20(22)-enolid
• apocynamarin
• 3-beta,5,14-trihydroxy-19-oxo-5-beta-card-20(22)-enolide
• 5BETA,20[22]-CARDENOLIDE-19-ONE-3BETA,5,14-TRIOL
• Strophanthidin,3β,5,14-Trihydroxy-19-oxo-5β,20(22)-cardenolide, Cymarigenen, K-Strophanthidin
• cymarigenin
• 3β,5,14-Trihydroxy-19-oxo-5β
• cyanotoxin
• Corchorogenin
• STIGMASTANOL(SH)
• 3BETA,5,14-TRIHYDROXY-19-OXO-5BETA,20[22]-CARDENOLIDE

Strophanthidin

CAS: 66-28-4

Strophanthidin

Purity: ≥90%

Molecular weight: 404.5g/mol

Ref: 54-BUP20029

Strophanthidin

CAS: 66-28-4

Formula: C₂₃H₃₂O₆

Purity: ≥ 92.0%

Color and Shape: White or almost white crystalline powder

Molecular weight: 404.50

Ref: 7W-GE5799

Strophanthidin

CAS: 66-28-4

Formula: C₂₃H₃₂O₆

Purity: 95%~99%

Molecular weight: 404.503

Ref: BP-BP1344

Strophanthidin

CAS: 66-28-4

Formula: C₂₃H₃₂O₆

Molecular weight: 404.50

Ref: 4Z-S-269004

Strophanthidin

CAS: 66-28-4

Strophanthidin (Strophanthidine) can induce calcium overload in vivo.

Formula: C₂₃H₃₂O₆

Purity: 93%

Color and Shape: Solid

Molecular weight: 404.5

Ref: TM-TN5073

Strophanthidine

CAS: 66-28-4

Lactone

Formula: C₂₃H₃₂O₆

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 404.5

Ref: 5G-83215