2-[N-(3-Trifluoromethylphenyl)amino]-5-nitropyridine, identified by its CAS number 6605-17-0, is a chemical compound that features a pyridine ring substituted with both a nitro group and an amino group linked to a trifluoromethylphenyl moiety. This compound typically exhibits characteristics common to nitropyridines, such as being a solid at room temperature and having moderate solubility in organic solvents. The presence of the trifluoromethyl group enhances its lipophilicity and may influence its biological activity, making it of interest in medicinal chemistry. The nitro group can participate in various chemical reactions, including reduction and nucleophilic substitution. Additionally, the compound may exhibit specific electronic properties due to the electron-withdrawing nature of the trifluoromethyl group, which can affect its reactivity and interactions with other molecules. Overall, this compound's unique structure suggests potential applications in pharmaceuticals, agrochemicals, or as a building block in organic synthesis.

2-[N-(3-trifluoromethylphenyl)amino]-5-nitropyridine

6605-17-0: 2-[N-(3-Trifluoromethylphenyl)amino]-5-nitropyridine, identified by its CAS number 6605-17-0, is a chemical compound that features a pyridine ring substituted with both a nitro group and an amino group linked to a trifluoromethylphenyl moiety. This compound typically exhibits characteristics common to nitropyridines, such as being a solid at room temperature and having moderate solubility in organic solvents. The presence of the trifluoromethyl group enhances its lipophilicity and may influence its biological activity, making it of interest in medicinal chemistry. The nitro group can participate in various chemical reactions, including reduction and nucleophilic substitution. Additionally, the compound may exhibit specific electronic properties due to the electron-withdrawing nature of the trifluoromethyl group, which can affect its reactivity and interactions with other molecules. Overall, this compound's unique structure suggests potential applications in pharmaceuticals, agrochemicals, or as a building block in organic synthesis.

<p>Compound EF2 (Androgen receptor antagonist 12) is an orally active antagonist of the androgen receptor (AR) with an IC50 of 0.30 µM. It inhibits the transcriptional activity of mutant AR and the proliferation of AR-positive PCa (prostate cancer) cell lines. Additionally, Compound EF2 blocks the nuclear translocation of AR and suppresses tumor growth in the C4-2B xenograft mouse model. This compound is used for research in prostate cancer.</p>

CAS 6605-17-0

2-[N-(3-trifluoromethylphenyl)amino]-5-nitropyridine

Androgen receptor antagonist 12

Ref: TM-T201604