CAS 66082-27-7

saframycin A

Description:

Saframycin A is a naturally occurring antibiotic compound that belongs to the class of compounds known as ansamycins. It is produced by certain strains of the bacterium *Micromonospora* and is characterized by its complex structure, which includes a bicyclic core and a unique side chain. Saframycin A exhibits potent antitumor activity, primarily through its ability to intercalate with DNA, thereby inhibiting DNA synthesis and transcription. This mechanism makes it a subject of interest in cancer research. The compound is also known for its ability to induce apoptosis in cancer cells. In terms of solubility, saframycin A is generally soluble in organic solvents but has limited solubility in water, which can affect its bioavailability. Its chemical properties, including stability and reactivity, are influenced by the presence of functional groups within its structure. Overall, saframycin A represents a significant area of study for its potential therapeutic applications in oncology and its unique chemical characteristics.

Formula: C₂₉H₃₀N₄O₈

Synonyms:

• N-[[(6S)-7α-Cyano-1,5,6,7,9,10,13,14,14aα,15-decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6α,15α-epimino-4H-isoquino[3,2-b][3]benzazocin-9β-yl]methyl]-2-oxopropionamide
• Propanamide, N-[[(6S,7R,9R,14aS,15R)-7-cyano-1,5,6,7,9,10,13,14,14a,15-decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxo-
• saframycin A
• NSC 325663

Saframycin A

CAS: 66082-27-7

Saframycin A exhibits antibacterial activity against Gram-positive bacteria and shows weaker effects on Gram-negative bacteria and mycobacteria. Additionally, it inhibits mouse lymphocyte L-1210 cells, with an ID50 of 0.0056 μM.

Formula: C₂₉H₃₀N₄O₈

Color and Shape: Solid

Molecular weight: 562.57

Ref: TM-TN10344