CAS 66082-30-2

saframycin D

Description:

Saframycin D is a naturally occurring antibiotic compound that belongs to the class of saframycins, which are known for their antitumor and antibacterial properties. It is produced by certain strains of the bacterium *Micromonospora* and exhibits a complex structure characterized by a bicyclic core and various functional groups that contribute to its biological activity. Saframycin D has shown efficacy against a range of cancer cell lines, making it a subject of interest in cancer research. Its mechanism of action primarily involves the inhibition of DNA synthesis, which disrupts the proliferation of cancer cells. Additionally, saframycin D has been studied for its potential use in combination therapies to enhance the effectiveness of other anticancer agents. The compound is typically characterized by its solubility in organic solvents and limited solubility in water, which can influence its bioavailability and therapeutic applications. Overall, saframycin D represents a significant area of study in the development of novel anticancer therapies.

Formula: C₂₈H₃₁N₃O₉

InChI: InChI=1/C28H31N3O9/c1-10-21(33)13-7-14-20-18-19(22(34)11(2)27(40-6)25(18)37)23(35)16(30(20)4)9-31(14)15(8-29-28(38)12(3)32)17(13)24(36)26(10)39-5/h14-16,20,34,37H,7-9H2,1-6H3,(H,29,38)/t14-,15-,16+,20-/m0/s1

Synonyms:

• N-{[(1R,2S,10R,13R)-16,19-Dihydroxy-7,18-dimethoxy-6,17,21-trimethyl-5,8,14-trioxo-11,21-diazapentacyclo[11.7.1.0~2,11~.0~4,9~.0~15,20~]henicosa-4(9),6,15,17,19-pentaen-10-yl]methyl}-2-oxopropanamide
• saframycin D
• Propanamide, N-[[(6R,9R,14aS,15R)-6,7,9,10,13,14,14a,15-octahydro-1,4-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-5,10,13-trioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxo-
• N-[[(6R)-6,7,9,10,13,14,14aα,15-Octahydro-1,4-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-5,10,13-trioxo-6α,15α-epimino-5H-isoquino[3,2-b][3]benzazocin-9β-yl]methyl]-2-oxopropionamide
• propanamide, N-[[(6R,9R,14aS,15R)-6,7,9,10,13,14,14a,15-octahydro-1,4-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-5,10,13-trioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxo-

Saframycin D

CAS: 66082-30-2

Saframycin D exhibits activity against Gram-positive bacteria and shows weaker potency against mycobacteria.

Formula: C₂₈H₃₁N₃O₉

Color and Shape: Solid

Molecular weight: 553.56

Ref: TM-TN9976