CAS 66085-59-4

Nimodipine

Description:

Nimodipine is a dihydropyridine calcium channel blocker primarily used in the medical field for its ability to improve cerebral blood flow. It is particularly indicated for the prevention of ischemic neurological deficits following subarachnoid hemorrhage. The compound is characterized by its selective action on cerebral blood vessels, leading to vasodilation without significantly affecting systemic blood pressure. Nimodipine has a relatively high lipophilicity, which facilitates its penetration across the blood-brain barrier. Its chemical structure includes a 1,4-dihydropyridine ring, which is essential for its pharmacological activity. The substance is typically administered orally or intravenously, and its pharmacokinetics involve rapid absorption and metabolism, with a relatively short half-life. Common side effects may include headache, hypotension, and gastrointestinal disturbances. Due to its specific action and side effect profile, nimodipine is a valuable therapeutic agent in neurology, particularly in managing conditions related to cerebral vasospasm.

Formula: C₂₁H₂₆N₂O₇

InChI: InChI=1/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,17,19H,9-10H2,1-5H3/t17?,19-/m0/s1

InChI key: InChIKey=UIAGMCDKSXEBJQ-UHFFFAOYSA-N

SMILES: C(OCCOC)(=O)C=1C(C(C(OC(C)C)=O)=C(C)NC1C)C2=CC(N(=O)=O)=CC=C2

Synonyms:

• 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid 2-Methoxyethyl 1-Methylethyl Ester
• 2-Methoxyethyl Propan-2-Yl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl) 5-(1-methylethyl) ester
• 3-(2-methoxyethyl) 5-(1-methylethyl) (4R)-2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate
• 3-(2-methoxyethyl) 5-(1-methylethyl) (4S)-2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate
• 3-O-(2-Methoxyethyl) 5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• Admon
• BAY-e 9736
• Isopropyl 2-Methoxyethyl 1,4-Dihydro-2,6-Dimethyl-4-(M-Nitrophenyl)-3,5-Pyridinedicarboxylate
• Nemotan
• Nimodipin
• Nimodipine AP
• Nimodipino
• Nimotop
• Periplum
• Nimodipine
• inedicarboxylate
• 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-METHYLOXYETHYL 1-METHYLETHYL ESTER
• isopropyl2-methoxyethyl1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyrid
• Bay e 9736, Admon, Nimotop, periplum
• NIMODIPINE EPN(CRM STANDARD)
• NIMODIPINE MM(CRM STANDARD)
• NIMODIPINE BP STANDARD(CRM STANDARD)
• 1,4-Dihydro-2,6-dimethyl-4-(3-ni-trophenyl)-3,5-pyridinedicarboxylicacid
• NIMODIPINE CALCIUM CHANNEL ANTAG
• ethoxyethyl1-methylethylester

Nimodipine, 98+%

CAS: 66085-59-4

Potent L-type calcium channel antagonist

Formula: C₂₁H₂₆N₂O₇

Purity: 98+%

Color and Shape: Powder

Molecular weight: 418.45

Ref: 02-J61287

Nimodipine

CAS: 66085-59-4

Color and Shape: Neat

Ref: 61-FOR0416.00

Nimodipine

CAS: 66085-59-4

Nimodipine

Formula: C₂₁H₂₆N₂O₇

Purity: 100.0%

Color and Shape: Yellow Solid

Molecular weight: 418.174

Ref: 47-651

NIMODIPINE CRS

CAS: 66085-59-4

NIMODIPINE CRS

Formula: C₂₁H₂₆N₂O₇

Molecular weight: 418.4403

Ref: 41-N0850000

Nimodipine

CAS: 66085-59-4

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₂₁H₂₆N₂O₇

Color and Shape: Yellow Crystalline Powder

Molecular weight: 418.174

Ref: 45-1463858

Nimodipine

CAS: 66085-59-4

Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.

Formula: C₂₁H₂₆N₂O₇

Purity: 99.64% - 99.79%

Color and Shape: Solid

Molecular weight: 418.44

Ref: TM-T0343

Nimodipine

CAS: 66085-59-4

Nimodipine

Purity: 98%

Molecular weight: 418.44g/mol

Ref: 54-OR1030244

Nimodipine

CAS: 66085-59-4

Formula: C₂₁H₂₆N₂O₇

Purity: ≥ 98.0% (anhydrous basis)

Color and Shape: Off-white to yellow powder

Molecular weight: 418.44

Ref: 7W-GP2955

Nimodipine

CAS: 66085-59-4

Nimodipine

Purity: ≥98%

Molecular weight: 418.44g/mol

Ref: 54-BUP14874

Nimodipine

CAS: 66085-59-4

Formula: C₂₁H₂₆N₂O₇

Color and Shape: Yellow Solid

Molecular weight: 418.45

Ref: 4Z-N-151

Nimodipine

Controlled Product

CAS: 66085-59-4

Formula: C₂₁H₂₆N₂O₇

Color and Shape: Neat

Molecular weight: 418.44

Ref: 86-MM0416.00

Nimodipine 100 µg/mL in Acetonitrile

CAS: 66085-59-4

Formula: C₂₁H₂₆N₂O₇

Color and Shape: Single Solution

Molecular weight: 418.44

Ref: 04-A15526800AL-100

Nimodipine

CAS: 66085-59-4

Formula: C₂₁H₂₆N₂O₇

Color and Shape: Neat

Molecular weight: 418.44

Ref: 04-C15526800

Nimodipine

CAS: 66085-59-4

Formula: C₂₁H₂₆N₂O₇

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 418.45

Ref: 3B-N0896

Nimodipine

CAS: 66085-59-4

Applications A dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral). Neuroprotective & Neuroresearch products.
References Allen, G.S., et al.: N. Engl. J. Med., 308, 619 (1983), Schluter, H.: Arzneim.-Forsch., 36, 1733 (1986), Deyo, R.A., et al.: Science, 243, 809 (1989),

Formula: C₂₁H₂₆N₂O₇

Color and Shape: Neat

Molecular weight: 418.44

Ref: TR-N478200

Nimodipine

CAS: 66085-59-4

Nimodipine is a medication that belongs to the group of calcium channel blockers. It is used as a treatment for cerebral vasospasm, subarachnoid hemorrhage, and hypertensive emergencies. Nimodipine inhibits calcium influx into cells by blocking voltage-sensitive L-type calcium channels in smooth muscle cells. This medication has been shown to be effective when used with other drugs in the treatment of vasospasm or after aneurysm surgery. Nimodipine has also been shown to increase blood flow and improve brain function in patients with head injuries. The effects of nimodipine on cerebral blood flow have been demonstrated using whole-cell recordings from brain slices.

Formula: C₂₁H₂₆N₂O₇

Purity: Min. 98 Area-%

Color and Shape: Slightly Yellow Powder

Molecular weight: 418.44 g/mol

Ref: 3D-II57946

Nimodipine

CAS: 66085-59-4

M02160 - Nimodipine

Formula: C₂₁H₂₆N₂O₇

Purity: 95%

Color and Shape: Solid

Molecular weight: 418.446

Ref: 10-M02160