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CAS 66085-59-4

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Nimodipine

Description:
Nimodipine is a dihydropyridine calcium channel blocker primarily used in the medical field for its ability to improve cerebral blood flow. It is particularly indicated for the prevention of ischemic neurological deficits following subarachnoid hemorrhage. The compound is characterized by its selective action on cerebral blood vessels, leading to vasodilation without significantly affecting systemic blood pressure. Nimodipine has a relatively high lipophilicity, which facilitates its penetration across the blood-brain barrier. Its chemical structure includes a 1,4-dihydropyridine ring, which is essential for its pharmacological activity. The substance is typically administered orally or intravenously, and its pharmacokinetics involve rapid absorption and metabolism, with a relatively short half-life. Common side effects may include headache, hypotension, and gastrointestinal disturbances. Due to its specific action and side effect profile, nimodipine is a valuable therapeutic agent in neurology, particularly in managing conditions related to cerebral vasospasm.
Formula:C21H26N2O7
InChI:InChI=1/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,17,19H,9-10H2,1-5H3/t17?,19-/m0/s1
InChI key:InChIKey=UIAGMCDKSXEBJQ-UHFFFAOYSA-N
SMILES:C(OCCOC)(=O)C=1C(C(C(OC(C)C)=O)=C(C)NC1C)C2=CC(N(=O)=O)=CC=C2
Synonyms:
  • 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid 2-Methoxyethyl 1-Methylethyl Ester
  • 2-Methoxyethyl Propan-2-Yl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl) 5-(1-methylethyl) ester
  • 3-(2-methoxyethyl) 5-(1-methylethyl) (4R)-2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate
  • 3-(2-methoxyethyl) 5-(1-methylethyl) (4S)-2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate
  • 3-O-(2-Methoxyethyl) 5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Admon
  • BAY-e 9736
  • Isopropyl 2-Methoxyethyl 1,4-Dihydro-2,6-Dimethyl-4-(M-Nitrophenyl)-3,5-Pyridinedicarboxylate
  • See more synonyms
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