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CAS 66104-22-1

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Pergolide

Description:
Pergolide is a synthetic ergot derivative primarily used as a medication for the treatment of Parkinson's disease and certain conditions related to hyperprolactinemia. It acts as a dopamine receptor agonist, specifically targeting D2 and D1 receptors, which helps to alleviate symptoms associated with dopamine deficiency. Pergolide is characterized by its complex chemical structure, which includes a bicyclic core typical of ergot alkaloids. The substance is typically administered orally and has a relatively long half-life, allowing for once-daily dosing in some cases. Its pharmacokinetics can be influenced by factors such as liver metabolism and individual patient characteristics. While effective, pergolide has been associated with potential side effects, including nausea, hallucinations, and cardiovascular complications, leading to its withdrawal from the market in some regions. As with any medication, careful monitoring and dosage adjustments are essential to optimize therapeutic outcomes while minimizing adverse effects.
Formula:C19H26N2S
InChI:InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1
InChI key:InChIKey=YEHCICAEULNIGD-MZMPZRCHSA-N
SMILES:C(CC)N1[C@]2([C@@](C=3C=4C(C2)=CNC4C=CC3)(C[C@@H](CSC)C1)[H])[H]
Synonyms:
  • (8β)-8-[(Methylthio)methyl]-6-propylergoline
  • 8-β-[(Methylthio)methyl]-6-(propionyl)ergoline
  • <span class="text-smallcaps">D</span>-8β-[(Methylthio)methyl]-6-propylergoline
  • D-8β-[(Methylthio)methyl]-6-propylergoline
  • Indolo[4,3-fg]quinoline, ergoline deriv.
  • Ly 141B
  • Pergolide
  • (6aR,9R,10aR)-9-[(methylsulfanyl)methyl]-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline
  • D-6-n-Propyl-8b-methylmercaptomethylergoline
  • (8beta)-8-[(methylsulfanyl)methyl]-6-propylergoline methanesulfonate (1:1)
  • See more synonyms
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Found 6 products.