CAS 66164-06-5

4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-2,2-diphenyl-butanamide

Description:

4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-2,2-diphenyl-butanamide, with CAS number 66164-06-5, is a chemical compound that belongs to the class of piperidine derivatives. It features a complex structure characterized by a piperidine ring substituted with a hydroxy group and a chlorophenyl moiety, along with a diphenylbutanamide backbone. This compound exhibits potential pharmacological properties, often investigated for its effects on the central nervous system. Its molecular structure suggests it may interact with various neurotransmitter systems, making it of interest in medicinal chemistry. The presence of the chlorophenyl group may enhance lipophilicity, influencing its bioavailability and pharmacokinetics. Additionally, the compound's amide functional group can contribute to its stability and reactivity. As with many chemical substances, safety and handling precautions are essential, as it may pose risks if not managed properly. Overall, this compound represents a significant area of study for researchers exploring therapeutic applications in neurology and psychiatry.

Formula: C₂₇H₂₉ClN₂O₂

InChI: InChI=1/C27H29ClN2O2/c28-24-13-11-21(12-14-24)26(32)15-18-30(19-16-26)20-17-27(25(29)31,22-7-3-1-4-8-22)23-9-5-2-6-10-23/h1-14,32H,15-20H2,(H2,29,31)

SMILES: c1ccc(cc1)C(CCN1CCC(CC1)(c1ccc(cc1)Cl)O)(c1ccccc1)C(=N)O

N-Didesmethyl Loperamide

Controlled Product

CAS: 66164-06-5

Applications A metabolite of Loperamide; a new and improved PET radiotracer for imaging P-gp function.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rahman, A., et al.: Cancer Res., 54, 5543 (1994), Sai, Y., et al.: Xenobiotica, 30, 327 (2000), Eneroth, A., et al.: Eur. J. Pharm. Sci., 12, 205 (2001), Kim, K., et al.: Drug Metab. Dispos., 31, 1090 (2003),

Formula: C₂₇H₂₉ClN₂O₂

Color and Shape: Off White Solid

Molecular weight: 448.98

Ref: TR-D441135

N-Didesmethyl Loperamide-d4

Controlled Product

CAS: 66164-06-5

Applications N-Didesmethyl Loperamide-d4 is the isotope labelled analog of N-Didesmethyl Loperamide (D441135); a metabolite of the antidiarrheal Loperamide (L469450, HCl). Also a new and improved PET radiotracer for imaging P-gp function.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Stokbroekx, et al.: J. Med. Chem., 1, 782 (1973); Carter, J.E., et al.: Anal. Profiles Drug Subs., 19, 341 (1990); Rahman, A., et al.: Cancer Res., 54, 5543 (1994); Sai, Y., et al.: Xenobiotica, 30, 327 (2000); Eneroth, A., et al.: Eur. J. Pharm. Sci., 12, 205 (2001); Kim, K., et al.: Drug Metab. Dispos., 31, 1090 (2003)

Formula: C₂₇H₂₅D₄ClN₂O₂

Color and Shape: Neat

Molecular weight: 391.738

Ref: TR-D441137

N-didesmethyl Loperamide

CAS: 66164-06-5

N-didesmethyl Loperamide, an active metabolite of the peripheral μ1-opioid receptor agonist loperamide, impedes electrically induced contractions in isolated

Formula: C₂₇H₂₉ClN₂O₂

Color and Shape: Solid

Molecular weight: 448.98

Ref: TM-T83899