CAS 6620-60-6

Proglumide

Description:

Proglumide is a synthetic compound primarily known for its role as a gastrointestinal agent, particularly as an antagonist of the cholecystokinin (CCK) receptor. It is classified as a non-peptide molecule and has been studied for its potential therapeutic applications, including the treatment of peptic ulcers and as an adjunct in cancer therapy due to its ability to modulate gastric acid secretion and influence digestive processes. Proglumide exhibits a relatively low solubility in water, which can affect its bioavailability and pharmacokinetics. The compound is characterized by its ability to inhibit the actions of CCK, a hormone that stimulates gallbladder contraction and pancreatic enzyme secretion. Additionally, proglumide has been investigated for its neuroprotective properties and potential effects on pain modulation. Its chemical structure includes functional groups that contribute to its biological activity, making it a subject of interest in pharmacological research. As with any pharmaceutical agent, understanding its mechanism of action, side effects, and interactions with other drugs is crucial for its safe and effective use.

Formula: C₁₈H₂₆N₂O₄

InChI: InChI=1S/C18H26N2O4/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22)

InChI key: InChIKey=DGMKFQYCZXERLX-UHFFFAOYSA-N

SMILES: C(C(N(CCC)CCC)=O)(NC(=O)C1=CC=CC=C1)CCC(O)=O

Synonyms:

• 4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid
• 4-benzamido-N,N-dipropyl-DL-glutaramic acid
• <span class="text-smallcaps">DL</span>-4-Benzamido-N,N-dipropylglutaramic acid
• <span class="text-smallcaps">DL</span>-Proglumide
• Binoside
• Cr 242
• Gastrotopic
• Glutaramic acid, 4-benzamido-N,N-dipropyl-, <span class="text-smallcaps">DL</span>-
• Midelid
• Milid
• Milide
• Nulsa
• N~2~-benzoyl-N,N-dipropyl-alpha-glutamine
• Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-
• Promid
• Promide (parasympatholytic)
• Ulcutin
• W 5219
• Xylamide
• Xylamide (gastroprotective agent)
• Glutaramic acid, 4-benzamido-N,N-dipropyl-, DL-

Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-

CAS: 6620-60-6

Formula: C₁₈H₂₆N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 334.4100

Ref: IN-DA00IBKM

Proglumide

CAS: 6620-60-6

Proglumide (Binoside), an anti-ulcer drug, is a CCKA/CCKB antagonist that lowers gastric secretion and gastrointestinal motility.

Formula: C₁₈H₂₆N₂O₄

Purity: 99.4% - 99.45%

Color and Shape: White Crystalline Powder

Molecular weight: 334.41

Ref: TM-T1052

Proglumide

CAS: 6620-60-6

Formula: C₁₈H₂₆N₂O₄

Molecular weight: 334.41

Ref: 7W-GP2761

Proglumide

CAS: 6620-60-6

Proglumide

Purity: ≥98%

Molecular weight: 334.41g/mol

Ref: 54-BUP15794

Proglumide

Controlled Product

CAS: 6620-60-6

Applications Anticholinergic.
References Umetzu, T., et al.: Eur. J. Pharmacol., 64, 69 (1980),

Formula: C₁₈H₂₆N₂O₄

Color and Shape: Neat

Molecular weight: 334.41

Ref: TR-P755955

Proglumide

CAS: 6620-60-6

Cholecystokinin antagonist; gastrin receptor antagonist

Formula: C₁₈H₂₆N₂O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 334.41 g/mol

Ref: 3D-FP27175

Proglumide - Bio-X ™

CAS: 6620-60-6

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₈H₂₆N₂O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 334.41 g/mol

Ref: 3D-BP166197