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CAS 66258-76-2

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Piperacillin monohydrate

Description:
Piperacillin monohydrate is a semisynthetic penicillin antibiotic that is primarily used to treat a variety of bacterial infections. It is characterized by its broad-spectrum activity against both Gram-positive and Gram-negative bacteria, making it effective in treating infections caused by organisms such as Pseudomonas aeruginosa. The chemical structure of piperacillin includes a beta-lactam ring, which is essential for its antibacterial activity, and a side chain that enhances its stability against certain beta-lactamases, enzymes produced by some bacteria to confer resistance. Piperacillin monohydrate is typically administered via injection and is often combined with a beta-lactamase inhibitor, such as tazobactam, to further extend its efficacy against resistant strains. In terms of physical properties, it is a white to off-white crystalline powder that is soluble in water. The monohydrate form indicates the presence of one molecule of water associated with each molecule of piperacillin, which can influence its stability and solubility. As with all antibiotics, appropriate use is crucial to minimize the development of resistance.
Formula:C23H27N5O7S·H2O
InChI:InChI=1S/C23H27N5O7S.H2O/c1-4-26-10-11-27(19(32)18(26)31)22(35)25-13(12-8-6-5-7-9-12)16(29)24-14-17(30)28-15(21(33)34)23(2,3)36-20(14)28;/h5-9,13-15,20H,4,10-11H2,1-3H3,(H,24,29)(H,25,35)(H,33,34);1H2/t13-,14-,15+,20-;/m1./s1
InChI key:InChIKey=NBXPLBPWMYNZTC-IDYPWDAWSA-N
SMILES:N(C([C@H](NC(=O)N1C(=O)C(=O)N(CC)CC1)C2=CC=CC=C2)=O)[C@H]3[C@@]4(N([C@@H](C(O)=O)C(C)(C)S4)C3=O)[H].O
Synonyms:
  • Piperacillin hydrate
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-, hydrate (1:1), (2S,5R,6R)-
  • Piperacillin monohydrate
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-, monohydrate, [2S-[2α,5α,6β(S*)]]-
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-, monohydrate, (2S,5R,6R)-
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Found 5 products.
  • CymitQuimica logo
    British Pharmacopoeia
    + Info

    Piperacillin

    CAS:
    Piperacillin
    Formula:C23H29N5O8S
    Purity:92.3%
    Color and Shape:Off-White
    Molecular weight:535.17368

    Ref: 47-1027

    100mg
    242.00€
  • CymitQuimica logo
    EDQM - European Pharmacopoeia
    + Info

    PIPERACILLIN CRS

    CAS:
    <p>PIPERACILLIN CRS</p>
    Formula:C23H27N5O7S
    Color and Shape:White. Powder.
    Molecular weight:517.5548

    Ref: 41-P1890000

    100mg
    115.00€
  • CymitQuimica logo
    USP
    + Info

    Piperacillin

    CAS:
    <p>Penicillins and their derivatives with a penicillanic acid structure and salts thereof, nesoi</p>
    Formula:C23H27N5O7S·H2O
    Color and Shape:White Off-White Powder
    Molecular weight:517.16312

    Ref: 45-1541500

  • CymitQuimica logo
    Japanese Pharmacopoeia
    + Info

    Piperacillin RS

    CAS:
    Color and Shape:White Solid Crystalline Powder

    Ref: 2K-7000820021

    100mg
    To inquire
  • Piperacillin hydrate
    Targetmol
    + Info

    Piperacillin hydrate

    CAS:
    <p>Piperacillin hydrate is a semisynthetic broad-spectrum β-lactam antibiotic. It exhibits potent bactericidal activity against Gram-negative bacteria and some Gram-positive bacteria by targeting penicillin-binding proteins. Piperacillin hydrate is frequently combined with the β-lactamase inhibitor Tazobactam for enhanced efficacy.</p>
    Formula:C23H29N5O8S
    Color and Shape:Solid
    Molecular weight:535.57

    Ref: TM-T204418