CAS 66309-69-1

Cefotiam hydrochloride

Description:

Cefotiam hydrochloride is a broad-spectrum cephalosporin antibiotic, primarily used for the treatment of various bacterial infections. It is characterized by its ability to inhibit bacterial cell wall synthesis, which is a crucial mechanism for its antibacterial activity. The compound is typically administered via injection and is effective against both Gram-positive and Gram-negative bacteria. Cefotiam hydrochloride is known for its stability in the presence of beta-lactamases, enzymes produced by some bacteria that confer resistance to other antibiotics. The substance is soluble in water, which facilitates its use in clinical settings. Its pharmacokinetics include rapid absorption and distribution in body tissues, with a relatively short half-life, necessitating multiple doses for sustained therapeutic effects. Common side effects may include gastrointestinal disturbances and allergic reactions, similar to other antibiotics. As with any antibiotic, appropriate susceptibility testing is recommended to ensure its effectiveness against specific pathogens. Overall, Cefotiam hydrochloride is a valuable option in the antibiotic arsenal, particularly for infections where other treatments may fail.

Formula: C₁₈H₂₃N₉O₄S₃·2ClH

InChI: InChI=1S/C18H23N9O4S3.2ClH/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10;;/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31);2*1H/t12-,15-;;/m1../s1

InChI key: InChIKey=BWRRTAXZCKVRON-DGPOFWGLSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(CC=3N=C(N)SC3)=O)C2=O)(SCC1CSC=4N(CCN(C)C)N=NN4)[H].Cl

Synonyms:

• (6R,7R)-7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride
• (6R-trans)-7-[2-(2-aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R-trans)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, hydrochloride (1:2), (6R,7R)-
• Abbott 48999
• Cefotiam Dihydrichloride
• Cefotiam dihydrochloride
• Cefotiam.2HCl(Cefotiam hydrochloride)
• Ceradon
• Halospor
• Pansporin
• Pansporine
• Spizef
• Sporidyn

Cefotiam dihydrochloride

CAS: 66309-69-1

A broad spectrum antibiotic

Formula: C₁₈H₂₃N₉O₄S₃•HCl

Molecular weight: 562.09

Ref: 02-J66529

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R,7R)-

CAS: 66309-69-1

Formula: C₁₈H₂₅Cl₂N₉O₄S₃

Purity: 96%

Color and Shape: Solid

Molecular weight: 598.5500

Ref: IN-DA00IBL5

Cefotiam hydrochloride

CAS: 66309-69-1

Cefotiam hydrochloride is a third-gen cephalosporin that disrupts bacterial cell wall synthesis by inhibiting PBPs.

Formula: C₁₈H₂₃N₉O₄S₃·2HCl

Purity: 98.23% - 99.98%

Color and Shape: Solid

Molecular weight: 598.60

Ref: TM-T1616

Cefotiam hydrochloride

CAS: 66309-69-1

Cefotiam hydrochloride

Purity: ≥98%

Molecular weight: 598.6g/mol

Ref: 54-BUP14507

Cefotiam Dihydrochloride

CAS: 66309-69-1

Cefotiam Dihydrochloride

Purity: 98%

Molecular weight: 598.54g/mol

Ref: 54-OR1030485

Cefotiam DiHCl

CAS: 66309-69-1

Formula: C₁₈H₂₃N₉O₄S₃·2HCl

Color and Shape: Off-White Solid

Molecular weight: 525.63 2*36.46

Ref: 4Z-C-10302

Cefotiam dihydrochloride hydrate

CAS: 66309-69-1

Formula: C₁₈H₂₃N₉O₄S₃·2HCl·xH₂O

Purity: ≥ 98.0%

Color and Shape: White, off-white to tan or yellow powder

Molecular weight: 598.55 (anhydrous)

Ref: 7W-GL6662

Cefotiam Hydrochloride RS

CAS: 66309-69-1

Color and Shape: White To Pale Yellow-White

Ref: 2K-7000460021

Cefotiam Dihydrochloride

CAS: 66309-69-1

Applications Cephalosporin Antibiotic.
References Murata, H., et al.: J. Hepatol., 38, 573 (2003), Osawa, M., et al.: Legal Med., 10, 143 (2008), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),

Formula: C₁₈H₂₃N₉O₄S₃HCl

Color and Shape: White To Light Yellow

Molecular weight: 598.55

Ref: TR-C243005

Cefotiam dihydrochloride

CAS: 66309-69-1

Cefotiam dihydrochloride is a semisynthetic antibiotic that belongs to the class of cephalosporin antibiotics. It inhibits bacterial growth by binding to penicillin-binding proteins and blocking cell wall synthesis. Cefotiam has been shown to be effective against Gram-positive bacteria, such as Streptococcus pneumoniae, Staphylococcus aureus, and Clostridium perfringens. This drug is used in the treatment of infectious diseases caused by Gram-positive bacteria, including meningitis, endocarditis, osteomyelitis, and peritonitis. The intravenous injection of cefotiam has been shown to be safe and well tolerated in adults with septicemia or bacteremia. Cefotiam is excreted unchanged in the urine.

Formula: C₁₈H₂₅Cl₂N₉O₄S₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 598.55 g/mol

Ref: 3D-FC19863

Cefotiam hydrochloride

CAS: 66309-69-1

Purity: 98%

Molecular weight: 598.54

Ref: 10-F979609

Cefotiam Dihydrochloride-13C, 15N2

Controlled Product

CAS: 61622-34-2, 66309-69-1

Applications Cefotiam Dihydrochloride-13C, 15N2 is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations.
References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)

Formula: C₁₇CH₂₃N₇N₂O₄S₃•2x(HCl)

Color and Shape: Neat

Molecular weight: 601.5295

Ref: TR-C243007

Cefotiam Hydrochloride (DISCONTINUED)

CAS: 66309-69-1

Antibiotics nesoi

Formula: C₁₈H₂₃N₉O₄S₃·2ClH

Color and Shape: Crystals

Molecular weight: 597.05687

Ref: 45-1098005