CAS 66309-69-1: Cefotiam hydrochloride
Description:Cefotiam hydrochloride is a broad-spectrum cephalosporin antibiotic, primarily used for the treatment of various bacterial infections. It is characterized by its ability to inhibit bacterial cell wall synthesis, which is a crucial mechanism for its antibacterial activity. The compound is typically administered via injection and is effective against both Gram-positive and Gram-negative bacteria. Cefotiam hydrochloride is known for its stability in the presence of beta-lactamases, enzymes produced by some bacteria that confer resistance to other antibiotics. The substance is soluble in water, which facilitates its use in clinical settings. Its pharmacokinetics include rapid absorption and distribution in body tissues, with a relatively short half-life, necessitating multiple doses for sustained therapeutic effects. Common side effects may include gastrointestinal disturbances and allergic reactions, similar to other antibiotics. As with any antibiotic, appropriate susceptibility testing is recommended to ensure its effectiveness against specific pathogens. Overall, Cefotiam hydrochloride is a valuable option in the antibiotic arsenal, particularly for infections where other treatments may fail.
Formula:C18H23N9O4S3·2ClH
InChI:InChI=1S/C18H23N9O4S3.2ClH/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10;;/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31);2*1H/t12-,15-;;/m1../s1
InChI key:InChIKey=BWRRTAXZCKVRON-DGPOFWGLSA-N
SMILES:Cl.O=C(O)C1=C(CSC2=NN=NN2CCN(C)C)CSC3N1C(=O)C3NC(=O)CC=4N=C(SC4)N
- Synonyms:
- (6R,7R)-7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride
- (6R-trans)-7-[2-(2-aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R,7R)-
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R-trans)-
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, hydrochloride (1:2), (6R,7R)-
- Abbott 48999
- Cefotiam Dihydrichloride
- Cefotiam dihydrochloride
- Cefotiam.2HCl(Cefotiam hydrochloride)
- Ceradon
- See more synonyms
- Halospor
- Pansporin
- Pansporine
- Spizef
- Sporidyn
- Cefotiam hydrochloride
![5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[…](https://static.cymitquimica.com/products/IN/thumb/DA00IBL5.jpg)
