CAS 66322-66-5

Propranolol glucuronide

Description:

Propranolol glucuronide is a metabolite of propranolol, a non-selective beta-adrenergic antagonist commonly used to treat conditions such as hypertension, anxiety, and certain types of tremors. As a glucuronide, it is formed through the process of glucuronidation, where a glucuronic acid moiety is conjugated to the parent drug, enhancing its solubility and facilitating excretion. This compound typically exhibits characteristics such as increased polarity compared to propranolol, which aids in renal elimination. Propranolol glucuronide is generally less pharmacologically active than its parent compound, serving primarily as a means of detoxification and elimination from the body. Its presence in biological fluids can be indicative of propranolol use and is often measured in pharmacokinetic studies. The compound is usually stable under physiological conditions, but its stability can be influenced by factors such as pH and temperature. Understanding the characteristics of propranolol glucuronide is essential for interpreting drug metabolism and pharmacotherapy outcomes in clinical settings.

Formula: C₂₂H₂₉NO₈

InChI: InChI=1S/C22H29NO8/c1-12(2)23-10-14(11-29-16-9-5-7-13-6-3-4-8-15(13)16)30-22-19(26)17(24)18(25)20(31-22)21(27)28/h3-9,12,14,17-20,22-26H,10-11H2,1-2H3,(H,27,28)/t14?,17-,18-,19+,20-,22+/m0/s1

InChI key: InChIKey=PCALHJGQCKATMK-PLEVBHNASA-N

SMILES: O(CC(O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O)CNC(C)C)C=2C3=C(C=CC2)C=CC=C3

Synonyms:

• 1-[[(1-Methylethyl)amino]methyl]-2-(1-naphthalenyloxy)ethyl β-D-glucopyranosiduronic acid
• Propranolol glucuronide
• β-D-Glucopyranosiduronic acid, 1-[[(1-methylethyl)amino]methyl]-2-(1-naphthalenyloxy)ethyl

Propranolol Glucuronide Sodium Salt (Mixture of Diastereomers)

CAS: 66322-66-5

Formula: C₂₂H₂₈NO₈·Na

Color and Shape: White To Off-White Solid

Molecular weight: 434.47 22.99

Ref: 4Z-P-161

(R,S)-Propranolol-O-β-D-glucuronide

CAS: 66322-66-5

(R,S)-Propranolol-O-β-D-glucuronide

Purity: >95%

Molecular weight: 435.47g/mol

Ref: 54-BICL4190

Propranolol-2-O-b-D-glucuronide

CAS: 66322-66-5

Formula: C₂₂H₂₉NO₈

Purity: ≥ 95%

Color and Shape: White lyophilised solid

Molecular weight: 435.47

Ref: 7W-GC9550

Propranolol-d5 Glucuronide

CAS: 66322-66-5

Formula: C₂₂H₂₄NO₈D₅

Color and Shape: Yellow Solid

Molecular weight: 440.51

Ref: 4Z-P-162

Propranolol-2-O-b-D-glucuronide

CAS: 66322-66-5

Propranolol-2-O-b-D-glucuronide is a metabolite of propranolol hydrochloride. It has been shown to have low bioavailability in humans and rats. Propranolol-2-O-b-D-glucuronide is eliminated via the kidney, with an elimination rate that is faster than the parent drug propranolol hydrochloride. The glucuronide conjugate of propranolol, which is found in urine samples, has been shown to be a potential biomarker for glomerular filtration rate and renal function.

Formula: C₂₂H₂₉NO₈

Purity: Min. 95%

Color and Shape: White to off-white solid.

Molecular weight: 435.47 g/mol

Ref: 3D-MP09955

Propranolol Glucuronide

CAS: 66322-66-5

Formula: C₂₂H₂₉NO₈

Molecular weight: 435.47

Ref: ST-EA-CP-P31020