CAS 664338-39-0

Arterolane

Description:

Arterolane, with the CAS number 664338-39-0, is an antimalarial compound that belongs to the class of 1,2,4-trioxolanes. It is primarily known for its activity against Plasmodium species, the parasites responsible for malaria. Arterolane functions by generating reactive oxygen species that damage the parasite's cellular components, leading to its death. This compound is often studied in combination with other antimalarial agents to enhance efficacy and reduce the likelihood of resistance development. Arterolane is characterized by its relatively low toxicity profile and favorable pharmacokinetic properties, which contribute to its potential as a therapeutic option in malaria treatment. Its development is part of ongoing efforts to combat malaria, particularly in regions where resistance to traditional antimalarial drugs is prevalent. Research continues to explore its effectiveness, optimal dosing regimens, and potential side effects in various populations.

Formula: C₂₂H₃₆N₂O₄

InChI: InChI=1/C22H36N2O4/c1-20(2,23)13-24-19(25)12-14-3-5-21(6-4-14)26-22(28-27-21)17-8-15-7-16(10-17)11-18(22)9-15/h14-18H,3-13,23H2,1-2H3,(H,24,25)/t14-,15?,16?,17-,18+,21+,22?

InChI key: InChIKey=VXYZBLXGCYNIHP-FMRWDXCZNA-N

SMILES: C(C(NCC(C)(C)N)=O)[C@H]1CC[C@]2(OC3([C@@]4(CC5C[C@]3(CC(C4)C5)[H])[H])OO2)CC1

Synonyms:

• cis-N-(2-Amino-2-methylpropyl)dispiro[cyclohexane-1,3′-[1,2,4]trioxolane-5′,2′′-tricyclo[3.3.1.13,7]decane]-4-acetamide
• Dispiro[cyclohexane-1,3′-[1,2,4]trioxolane-5′,2′′-tricyclo[3.3.1.13,7]decane]-4-acetamide, N-(2-amino-2-methylpropyl)-, cis-
• Arterolane
• OZ 277

Arterolane

CAS: 664338-39-0

Formula: C₂₂H₃₆N₂O₄

Purity: 99%

Molecular weight: 392.5322

Ref: IN-DA00FCX1

Arterolane

CAS: 664338-39-0

Formula: C₂₂H₃₆N₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 392.54

Ref: 4Z-A-226001

Arterolane-d6

CAS: 664338-39-0

Formula: C₂₂H₃₀D₆N₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 398.58

Ref: 4Z-A-226002

Arterolane

CAS: 664338-39-0

Purity: ¡Ý98.0%

Molecular weight: 392.54

Ref: 10-F979810

Arterolane-d6 Tosylate Salt

Controlled Product

CAS: 664338-39-0

Formula: C₂₉H₃₈D₆N₂O₇S

Color and Shape: Neat

Molecular weight: 398.569

Ref: TR-A614162

Arterolane

CAS: 664338-39-0

Arterolane is an antimalarial compound. For against P. falciparum Ro73 and W2, the IC50s are both 1.1 nM.

Formula: C₂₂H₃₆N₂O₄

Color and Shape: Solid

Molecular weight: 392.53

Ref: TM-T14325