CAS 66447-31-2

L-Leucine-7-amido-4-methylcoumarin

Description:

L-Leucine-7-amido-4-methylcoumarin (CAS 66447-31-2) is a synthetic compound primarily used as a substrate in biochemical assays, particularly for studying proteolytic enzymes. This compound features a coumarin moiety, which is known for its fluorescent properties, making it useful in fluorescence-based detection methods. The presence of the L-leucine amino acid contributes to its specificity for certain enzymes, particularly those that cleave peptide bonds. The structure of L-Leucine-7-amido-4-methylcoumarin allows it to be hydrolyzed by proteases, releasing the fluorescent coumarin, which can be quantitatively measured. This characteristic makes it valuable in research applications, including enzyme kinetics and the study of protein interactions. Additionally, the compound is generally stable under standard laboratory conditions, although it should be stored properly to maintain its integrity. As with many chemical substances, safety precautions should be observed when handling it, including the use of appropriate personal protective equipment.

Formula: C₁₆H₂₀N₂O₃

InChI: InChI=1S/C16H20N2O3/c1-9(2)6-13(17)16(20)18-11-4-5-12-10(3)7-15(19)21-14(12)8-11/h4-5,7-9,13H,6,17H2,1-3H3,(H,18,20)/t13-/m0/s1

InChI key: InChIKey=GTAAIHRZANUVJS-ZDUSSCGKSA-N

SMILES: CC=1C=2C(=CC(NC([C@H](CC(C)C)N)=O)=CC2)OC(=O)C1

Synonyms:

• (2S)-2-Amino-4-methyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)pentanamide
• (2S)-2-Amino-4-methyl-N-(4-methyl-2-oxochromen-7-yl)pentanamide
• <span class="text-smallcaps">L</span>-Leucine 4-methylcoumaryl-7-amide
• <span class="text-smallcaps">L</span>-Leucine-7-amido-4-methylcoumarin
• <span class="text-smallcaps">L</span>-Leucine-AMC
• H-Leu-AMC
• N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-leucinamide
• Pentanamide, 2-amino-4-methyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, (2S)-
• Pentanamide, 2-amino-4-methyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, (S)-
• L-Leucine 4-methylcoumaryl-7-amide
• L-Leucine-AMC

L-Leucine 7-amido-4-methylcoumarin hydrate

CAS: 66447-31-2

A sensitive fluorogenic substrate for leucine aminopeptidase and aminopeptidase M

Formula: C₁₆H₂₀N₂O₃

Color and Shape: Powder

Molecular weight: 288.35

Ref: 02-J64951

H-Leu-AMC

CAS: 66447-31-2

Highly sensitive fluorogenic substrate for leucine aminopeptidase and aminopeptidase M.

Formula: C₁₆H₂₀N₂O₃

Purity: > 99%

Color and Shape: White Powder

Molecular weight: 288.35

Ref: 01-4030806

H-Leu-AMC

CAS: 66447-31-2

Highly sensitive fluorogenic substrate for leucine aminopeptidase and aminopeptidase M.

Formula: C₁₆H₂₀N₂O₃

Purity: > 99%

Color and Shape: White

Molecular weight: 288.35

Ref: 01-4001570

H-Leu-amc

CAS: 66447-31-2

Formula: C₁₆H₂₀N₂O₃

Purity: ≥98%

Molecular weight: 288.3416

Ref: IN-DA00FEMY

Leu-MCA

CAS: 66447-31-2

Leu-MCA is a peptide that is an activator of ion channels. It is used as a research tool for the study of protein interactions, receptor and ligand binding, and pharmacology. Leu-MCA can be used to study the activation of ion channels by G-protein coupled receptors. In this way, Leu-MCA can be used to investigate the structure and function of these proteins in cells. The high purity of Leu-MCA offers researchers a means to control the concentration of this compound in experiments.

Formula: C₁₆H₂₀N₂O₃

Purity: Min. 95%

Molecular weight: 288.34 g/mol

Ref: 3D-MLM-3091-V

H-LEU-AMC

CAS: 66447-31-2

Formula: C₁₆H₂₀N₂O₃

Purity: ≥98%

Molecular weight: 288.347

Ref: 10-F475467

L-Leucine 7-Amido-4-methylcoumarin

Controlled Product

CAS: 66447-31-2

Formula: C₁₆H₂₀N₂O₃

Color and Shape: Neat

Molecular weight: 314.422

Ref: TR-L330618