CAS 66514-99-6

(S)-4-Amino-3-(4-chlorophenyl)butanoic acid

Description:

(S)-4-Amino-3-(4-chlorophenyl)butanoic acid, commonly known as baclofen, is a chemical compound characterized by its structural features that include an amino group, a carboxylic acid group, and a chlorophenyl moiety. It is a chiral molecule, with the (S) configuration indicating the specific spatial arrangement of its atoms. This compound is primarily recognized for its role as a muscle relaxant and is used in the treatment of spasticity associated with conditions such as multiple sclerosis and spinal cord injuries. Baclofen acts as a GABA-B receptor agonist, influencing neurotransmitter activity in the central nervous system. In terms of physical properties, it is typically a white to off-white crystalline powder that is soluble in water and exhibits a moderate melting point. Its pharmacological profile includes effects on both the central and peripheral nervous systems, making it significant in therapeutic applications. Safety and efficacy profiles are well-documented, with common side effects including drowsiness and dizziness.

Formula: C₁₀H₁₂ClNO₂

InChI: InChI=1/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)/t8-/m1/s1

SMILES: c1cc(ccc1[C@H](CC(=O)O)CN)Cl

Synonyms:

• L-Baclofen
• (+)-Baclofen
• (S)-Baclofen
• Unii-3Ohn4989Xm
• Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-, (betaS)-

(S)-Baclofen

CAS: 66514-99-6

Formula: C₁₀H₁₂ClNO₂

Color and Shape: Solid

Molecular weight: 213.6608

Ref: IN-DA006KRL

(S)-Baclofen

CAS: 66514-99-6

Formula: C₁₀H₁₂ClNO₂

Molecular weight: 213.66

Ref: 4Z-B-408

(S)-Baclofen

Controlled Product

CAS: 66514-99-6

Applications S-Enantiomer of Baclofen. Specific GABA-B receptor agonist. Muscle relaxant (skeletal).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ahuja, S., et al.: Anal. Profiles Drug Subs., 14, 527 (1985), Brogden, R.N., et al.: Drugs, 8,1 (1974)

Formula: C₁₀H₁₂ClNO₂

Color and Shape: Neat

Molecular weight: 213.66

Ref: TR-B107995

(S)-Baclofen-d4

Controlled Product

CAS: 66514-99-6

Formula: C₁₀D₄H₈ClNO₂

Color and Shape: Neat

Molecular weight: 217.685

Ref: TR-B107997

(S)-Baclofen

Controlled Product

CAS: 66514-99-6

GABA(B) agonist; anti-spastic agent; skeletal muscle relaxant

Formula: C₁₀H₁₂ClNO₂

Purity: Min. 95%

Molecular weight: 213.66 g/mol

Ref: 3D-FB18126

(S)-Baclofen

CAS: 66514-99-6

(S)-Baclofen may treat hyperacusis and tinnitus by reducing auditory pathway excitation.

Formula: C₁₀H₁₂ClNO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 213.66

Ref: TM-T20962

(S)-Baclofen

CAS: 66514-99-6

Formula: C₁₀H₁₂ClNO₂

Molecular weight: 213.66

Ref: ST-EA-CP-B3025