CAS 66547-09-9

ansamitocin P-3

Description:

Ansamitocin P-3 is a natural product derived from the bacterium *Nocardia sp.* and is classified as an ansamycin antibiotic. It exhibits a complex structure characterized by a macrocyclic lactam ring and a unique polyketide backbone, which contributes to its biological activity. This compound is known for its potent antitumor properties, primarily through its ability to inhibit microtubule assembly, thereby disrupting mitotic processes in cancer cells. Ansamitocin P-3 has garnered interest in the field of cancer research and drug development due to its selective cytotoxicity against various tumor cell lines. Additionally, it has been studied for its potential use in targeted therapies, often in conjunction with drug delivery systems to enhance its efficacy and reduce systemic toxicity. Its chemical formula and molecular weight reflect its complex structure, and it is typically handled with care in laboratory settings due to its bioactive nature. Overall, ansamitocin P-3 represents a significant compound in the exploration of novel anticancer agents.

Formula: C₃₂H₄₃ClN₂O₉

InChI: InChI=1/C32H43ClN2O9/c1-8-10-27(37)43-25-16-26(36)35(5)21-14-20(15-22(40-6)28(21)33)13-18(2)11-9-12-24(41-7)32(39)17-23(42-30(38)34-32)19(3)29-31(25,4)44-29/h9,11-12,14-15,19,23-25,29,39H,8,10,13,16-17H2,1-7H3,(H,34,38)/b12-9+,18-11-/t19-,23+,24-,25-,29+,31+,32+/m1/s1

Synonyms:

• Maytansinol butyrate
• 3-De(2-(acetylmethylamino)propionyloxy)-3-hydroxymaytansine butyrate (ester)
• Antibiotic C 15003P3'
• C 15003 P-3'
• Maytansine, 3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-, butyrate (ester)
• Maytansine, O(sup 3)-de(2-(acetylmethylamino)-1-oxopropyl)-O(sup 3)-(1-oxobutyl)- (9CI)
• (1S,2R,3S,5S,6R,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl butanoate
• ansamitocin P-3 from actinosynnema*pretiosum
• Ansamitocin P-3'

3-O-De[2-(acetylmethylamino)-1-oxopropyl]-3-O-(1-oxobutyl)maytansine

CAS: 66547-09-9

Formula: C₃₂H₄₃ClN₂O₉

Purity: 95%

Color and Shape: Solid

Molecular weight: 635.1448

Ref: IN-DA003AC0

Ansamitocin P 3'

CAS: 66547-09-9

Ansamitocin P 3'

Purity: ≥98%

Molecular weight: 635.14g/mol

Ref: 54-BUP09667

Ansamitocin P 3'

CAS: 66547-09-9

Ansamitocin P 3' (Maytansinol butyrate) is an antibody-drug conjugate cytotoxin with antitumor activity.

Formula: C₃₂H₄₃ClN₂O₉

Purity: 98.16% - 99.16%

Color and Shape: Solid

Molecular weight: 635.14

Ref: TM-T1910