CAS 66575-29-9

Forskolin

Description:

Forskolin is a natural compound derived from the root of the Coleus forskohlii plant, a member of the mint family. It is classified as a labdane diterpene and is known for its distinctive chemical structure, which includes a bicyclic framework. Forskolin is recognized for its ability to activate adenylate cyclase, an enzyme that increases the levels of cyclic adenosine monophosphate (cAMP) in cells, leading to various physiological effects. This mechanism has garnered interest in the fields of pharmacology and biochemistry, particularly for its potential applications in weight management, cardiovascular health, and asthma treatment. Forskolin is typically available in various forms, including powders and extracts, and is often marketed as a dietary supplement. Its solubility is primarily in organic solvents, and it exhibits a relatively low toxicity profile. However, as with any supplement, it is essential to consult healthcare professionals before use, especially for individuals with underlying health conditions or those taking other medications.

Formula: C₂₂H₃₄O₇

InChI: InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1

InChI key: InChIKey=OHCQJHSOBUTRHG-KGGHGJDLSA-N

SMILES: O[C@@]12[C@]3(C)[C@@]([C@H](O)[C@H](OC(C)=O)[C@@]1(C)O[C@](C=C)(C)CC2=O)(C(C)(C)CC[C@@H]3O)[H]

Synonyms:

• (3R,4aR,5S,6S,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate
• (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
• (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-Dodecahydro-5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyl-1H-naphtho(2,1-b)pyran-1-one 5-acetate
• 1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10balpha))-
• 1H-Naphtho(2,1-b)pyran-1-one, dodecahydro-5-(acetyloxy)-3-ethenyl-3,4a,7,7,10a-pentamethyl-6,10,10b-trihydroxy-, (3R-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,10-alpha,10a-beta,10b-alpha))-
• 1H-Naphtho[2,1-b]pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-
• 1H-Naphtho[2,1-b]pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-
• 3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate
• 7-beta-Acetoxy-8,13-epoxy-1-alpha,6-beta,9-alpha-trihydroxylabd-14-en-11-one
• Boforsin
• Coleonol
• Colforsina
• Colforsina [Spanish]
• Colforsine
• Colforsine [French]
• Colforsinum
• Colforsinum [Latin]
• ForsLean
• Forskolin
• Hl 362
• L 75 1362B
• M 410
• Nsc 357088
• Nsc 375489

Forskolin

CAS: 66575-29-9

Formula: C₂₂H₃₄O₇

Purity: >95.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 410.51

Ref: 3B-F0855

Forskolin, 98+%

CAS: 66575-29-9

Forskolin (coleonol), 66575-29-9, is a labdane diterpenoid isolated from the Indian Coleus plant which acts as an adenylyl cyclase activator. Learn more.

Formula: C₂₂H₃₄O₇

Purity: 98+%

Color and Shape: Powder, White

Molecular weight: 410.51

Ref: 02-J63292

Forskolin

CAS: 66575-29-9

Forskolin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₂₂H₃₄O₇

Purity: (HPLC) ≥99%

Color and Shape: Powder

Molecular weight: 410.51

Ref: 11-3733S

Forskolin (7β-acetoxy-8,13-epoxy-1α,6β,9α-trihydroxy-labd-14-en-11-one)

CAS: 66575-29-9

Heterocyclic compounds with oxygen hetero-atom(s) only nesoi

Formula: C₂₂H₃₄O₇

Color and Shape: White Crystalline Powder

Molecular weight: 410.23045

Ref: 45-1283244

Forskolin

CAS: 66575-29-9

Formula: C₂₂H₃₄O₇

Purity: 97%

Color and Shape: Solid

Molecular weight: 410.5012

Ref: IN-DA003QOW

Forskolin

CAS: 66575-29-9

Forskolin

Purity: ≥98%

Molecular weight: 410.5g/mol

Ref: 54-BUP17787

Forskolin from coleus forskohlii

CAS: 66575-29-9

Forskolin from coleus forskohlii

Formula: C₂₂H₃₄O₇

Purity: By hplc: >98% (Typical Value in Batch COA)

Color and Shape: white powder

Molecular weight: 410.50g/mol

Ref: 54-BIF1031

Forskolin

CAS: 66575-29-9

Formula: C₂₂H₃₄O₇

Purity: ≥ 98.0% (anhydrous basis)

Color and Shape: White to off-white powder

Molecular weight: 410.51

Ref: 7W-GP2059

Forskolin

CAS: 66575-29-9

Oridonin has anticancer activity, might be useful as adjunctive therapy for individuals with lymphoid malignancies, including the lethal disease adult T-cell leukemia.It inhibits tumor growth in glioma by inducing cell cycle arrest and apoptosis, inhibits BxPC-3 cell growth through cell apoptosis.

Formula: C₂₂H₃₄O₇

Purity: 95%~99%

Molecular weight: 410.507

Ref: BP-BP0593

Forskolin

CAS: 66575-29-9

Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM).

Formula: C₂₂H₃₄O₇

Purity: 98.83% - 99.96%

Color and Shape: Less Crystalline Solid Colorless Crystalline Solid

Molecular weight: 410.50

Ref: TM-T2939

Forskolin

CAS: 66575-29-9

Formula: C₂₂H₃₄O₇

Molecular weight: 410.51

Ref: 4Z-F-238001

Forskolin

CAS: 66575-29-9

Oxygen-heterocyclic compound

Formula: C₂₂H₃₄O₇

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 410.51

Ref: 5G-89664

Forskolin

CAS: 66575-29-9

Applications Forskolin is a diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties. Forskolin resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cAMP.
References Lindner, E., et al.: Arzneim.-Forsch., 28, 284 (1984), Hoever, G., et al.: J. Med. Chem., 48, 1256 (2005), Lai, S., et al.: Eur. J. Clin. Microbiol. Infect. Dis., 24, 5831 (2005),

Formula: C₂₂H₃₄O₇

Color and Shape: Neat

Molecular weight: 410.50

Ref: TR-F701800

Forskolin

CAS: 66575-29-9

Forskolin is a diterpene compound from Asian medicinal plant Coleus forskohlii. It is an activator of adenylate cyclase, causing increase in cellular levels of cAMP. It has anti-neuroinflammatory activity since it reduced microglial activation and astrocyte activation in the brain of rodent models for cerebral amyloidosis. Forskolin also reduced amyloid beta plaques deposition in cortex and hippocampus.

Formula: C₂₂H₃₄O₇

Purity: Min. 97 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 410.5 g/mol

Ref: 3D-FF23593

Forskolin - Bio-X ™

CAS: 66575-29-9

Forskolin is a compound derived from the medicinal plant Coleus forskohlii. As an activator of adenylate cyclase, Forskolin causes increases cellular levels of cAMP, and can be used in cell physiology research. It also has antihypertensive, platelet aggregation inhibitory and smooth muscle relaxant effects.

Formula: C₂₂H₃₄O₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 410.5 g/mol

Ref: 3D-BF164487

Forskolin

CAS: 66575-29-9

Purity: 97%

Molecular weight: 410.51

Ref: 10-M04088