CAS 66584-72-3

Ansamitocin P 3

Description:

Ansamitocin P3 is a potent antitumor agent derived from the bacterium *Nocardia sp.* It belongs to the class of compounds known as ansamycins, which are characterized by their complex polycyclic structures. This compound exhibits a unique mechanism of action by inhibiting microtubule polymerization, thereby disrupting mitotic spindle formation and leading to cell cycle arrest in cancer cells. Ansamitocin P3 is known for its high cytotoxicity against various cancer cell lines, making it a subject of interest in cancer research. The compound is typically studied in the context of drug development due to its potential therapeutic applications. Its solubility and stability can vary depending on the formulation and conditions, which are critical factors in its efficacy as a therapeutic agent. Additionally, like many natural products, Ansamitocin P3 may exhibit specific pharmacokinetic properties, influencing its absorption, distribution, metabolism, and excretion in biological systems. Overall, Ansamitocin P3 represents a significant area of study in the search for effective cancer treatments.

Formula: C₃₂H₄₃ClN₂O₉

InChI: InChI=1S/C32H43ClN2O9/c1-17(2)29(37)43-25-15-26(36)35(6)21-13-20(14-22(40-7)27(21)33)12-18(3)10-9-11-24(41-8)32(39)16-23(42-30(38)34-32)19(4)28-31(25,5)44-28/h9-11,13-14,17,19,23-25,28,39H,12,15-16H2,1-8H3,(H,34,38)/b11-9+,18-10+/t19-,23+,24-,25+,28+,31+,32+/m1/s1

InChI key: InChIKey=OPQNCARIZFLNLF-JBHFWYGFSA-N

SMILES: C[C@]12[C@@](O1)([C@H](C)[C@@]3(C[C@](O)([C@H](OC)/C=C/C=C(\C)/CC4=CC(N(C)C(=O)C[C@@H]2OC(C(C)C)=O)=C(Cl)C(OC)=C4)NC(=O)O3)[H])[H]

Synonyms:

• 2′-De(acetylmethylamino)-2′-methylmaytansine
• 4,24-Dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosane, maytansine deriv.
• Ansamitocin P 3
• Maytansinol isobutyrate
• Maytansine, 2′-de(acetylmethylamino)-2′-methyl-

Maytansinol isobutyrate

CAS: 66584-72-3

Formula: C₃₂H₄₃ClN₂O₉

Purity: 95%

Color and Shape: Solid

Molecular weight: 635.1448

Ref: IN-DA00FC1E

Ansamitocin p-3

CAS: 66584-72-3

Ansamitocin p-3

Formula: C₃₂H₄₃ClN₂O₉

Purity: ≥98%

Molecular weight: 635.14

Ref: 54-BUP03704

Ansamitocin P-3

CAS: 66584-72-3

Formula: C₃₂H₄₃ClN₂O₉

Purity: Ansamitocin P-3: ≥ 80.0%

Color and Shape: White to off-white powder

Molecular weight: 635.14

Ref: 7W-GL3182

Ansamitocin P3

CAS: 66584-72-3

Formula: C₃₂H₄₃ClN₂O₉

Purity: 95%~99%

Molecular weight: 635.151

Ref: BP-BPK001

Ansamitocin P 3

CAS: 66584-72-3

Formula: C₃₂H₄₃ClN₂O₉

Molecular weight: 635.15

Ref: 4Z-M-116036

Ansamitocin P-3

CAS: 66584-72-3

(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-Cchloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl isobutyrate

Formula: C₃₂H₄₃ClN₂O₉

Purity: 98% P-3 major, mix(P-0, P-1, P-2, P-3, P-3’, P-4, P-4’)

Molecular weight: 635.14

Ref: IN-DG630809

Ansamitocin P-3

CAS: 66584-72-3

Ansamitocin P-3

Formula: C₃₂H₄₃ClN₂O₉

Purity: 98%

Color and Shape: Solid

Molecular weight: 635.14482

Ref: 54-BIM0141

Ansamitocin p-3

CAS: 66584-72-3

Ansamitocin p-3 (Maytansinol isobutyrate) is an inhibitor of microtubule with IC50 of 3.4 μM for tubulin polymerization.

Formula: C₃₂H₄₃ClN₂O₉

Purity: 99.93%

Color and Shape: Solid

Molecular weight: 635.14

Ref: TM-T22262

Ansamitocin P-3

CAS: 66584-72-3

Ansamitocin P-3 is a mutant strain of Actinosynnema pretiosum that was originally isolated from the soil near a coal mine in China. The strain has been expressed as a piperidine molecule and maytansinol (a molecule found in the Chinese herb, mayten). The Ansamitocin P-3 molecule has shown anticancer activity against human cancer cells, with IC50 values of 0.2 and 0.5 μM for human breast cancer cells and lung cancer cells, respectively. It also has antiviral activity against HIV-1 with an EC50 value of 3.2 μM.

Formula: C₃₂H₄₃ClN₂O₉

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 635.14 g/mol

Ref: 3D-FA35435