CAS 66592-87-8

Cefadroxil monohydrate

Description:

Cefadroxil monohydrate is a semisynthetic antibiotic belonging to the cephalosporin class, primarily used to treat bacterial infections. It is characterized by its broad-spectrum activity against both Gram-positive and Gram-negative bacteria, making it effective for various infections, including those of the skin, respiratory tract, and urinary system. The chemical structure of cefadroxil includes a beta-lactam ring, which is essential for its antibacterial action, as it inhibits bacterial cell wall synthesis. Cefadroxil monohydrate appears as a white to off-white crystalline powder and is soluble in water, which facilitates its formulation in oral dosage forms. The monohydrate form indicates that it contains one molecule of water for each molecule of cefadroxil, influencing its stability and solubility. Commonly administered orally, cefadroxil is generally well-tolerated, though potential side effects may include gastrointestinal disturbances and allergic reactions. Its pharmacokinetics involve absorption in the gastrointestinal tract, with peak plasma concentrations occurring within a few hours post-administration.

Formula: C₁₆H₁₇N₃O₅S

InChI: InChI=1/C16H17N3O5S.H2O/c1-7-6-25-15-11(14(22)19(15)12(7)16(23)24)18-13(21)10(17)8-2-4-9(20)5-3-8;/h2-5,10-11,15,20H,6,17H2,1H3,(H,18,21)(H,23,24);1H2/t10?,11-,15-;/m1./s1

InChI key: InChIKey=NBFNMSULHIODTC-CYJZLJNKSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC([C@H](N)C3=CC=C(O)C=C3)=O)C2=O)(SCC1C)[H].O

Synonyms:

• (6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate (1:1)
• (6R,7R)-7-{[amino(4-hydroxyphenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-{[amino(4-hydroxyphenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-((amino(4-hydroxyphenyl)acetyl)amino)-3-methyl-8-oxo, monohydrate, (6R-(6alpha,7beta(R*)))-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-, hydrate (1:1), (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-amino(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-, monohydrate, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[amino(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-, monohydrate, [6R-[6α,7β(R*)]]-
• 7-{[Amino(4-Hydroxyphenyl)Acetyl]Amino}-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
• Cefadroxil Micronised Powder
• Duricef
• Ultracef
• Cefadroxil monohydrate
• (6R,7R)-7-[[(2R)-Amino-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Monohydrate
• CEFADROXIL
• Cefradroxil
• AMOXYCILLIN
• CEFADDROXIL
• Cefa-Drops
• Cefadroxil hydrate
• (6R,7R)-7-[(R)-2-AMINO-2-(4-HYDROXY-PHENYL)-ACETYLAMINO]-3-METHYL-8-OXO-5-THIA-1-AZA-BICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID
• CEFAMOX
• MJF-11567-3
• monohydrate,(6r-(6-alpha,7-beta(r*)))-l)acetyl)amino)-3-methyl-8-oxo
• (6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate
• Baxan
• 7-[[2-Amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 7-(2R)-amino(4-hydroxyphenyl)acetylamino-3-methyl-8-oxo-, monohydrate, (6R,7R)-
• p-Hydroxycephalexine Monohydrate
• Duracef
• 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((amino(4-hydroxyphenyl)acetyl) amino)-3-methyl-8-oxo-, monohydrate, (6R-(6-alpha,7-beta(R*)))

Cefadroxil Monohydrate

CAS: 66592-87-8

Color and Shape: Neat

Ref: 61-FOR0972.00

Cefadroxil

CAS: 66592-87-8

Cefadroxil

Formula: C₁₆H₁₇N₃O₅S

Purity: 93.8%

Color and Shape: White

Molecular weight: 363.08889

Ref: 47-784

CEFADROXIL CRS

CAS: 66592-87-8

CEFADROXIL CRS

Ref: 41-C0650000

Cefadroxil

CAS: 66592-87-8

Antibiotics nesoi

Formula: C₁₆H₁₇N₃O₅S·H₂O

Color and Shape: White Light Yellow Powder

Molecular weight: 363.08889

Ref: 45-1097104

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2R)-amino(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-,monohydrate, (6R,7R)-

CAS: 66592-87-8

Formula: C₁₆H₁₉N₃O₆S

Purity: 97%

Color and Shape: Solid

Molecular weight: 381.4036

Ref: IN-DA01CCHV

Cefadroxil monohydrate

CAS: 66592-87-8

Formula: C₁₆H₁₇N₃O₅S·H₂O

Purity: 98.0 - 102.0 %

Color and Shape: White or off-white powder

Molecular weight: 381.40

Ref: 7W-GA2276

(6R,7R)-7-((R)-2-Amino-2-(4-Hydroxyphenyl)Acetamido)-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Hydrate

CAS: 66592-87-8

(6R,7R)-7-((R)-2-Amino-2-(4-Hydroxyphenyl)Acetamido)-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Hydrate

Purity: 97%

Molecular weight: 381.4g/mol

Ref: 54-OR1028850

Cefadroxil Monohydrate

Controlled Product

CAS: 50370-12-2, 66592-87-8

Formula: C₁₆H₁₇N₃O₅S

Color and Shape: Neat

Molecular weight: 363.39

Ref: 86-MM0972.00

Cefadroxil Monohydrate

CAS: 66592-87-8

Formula: C₁₆H₁₇N₃O₅S·H₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 381.41

Ref: 3B-C3951

Cefadroxil Monohydrate

Controlled Product

CAS: 66592-87-8

Applications Cefadroxil is a semi-synthetic cephalosporin antibiotic. Antibacterial.
References Buck, R.E., et al.: Antimicrob. Agents Chemother., 11, 324 (1977);

Formula: C₁₆H₁₇N₃O₅S·H₂O

Color and Shape: White

Molecular weight: 381.40

Ref: TR-C235750

Cefadroxil monohydrate

CAS: 66592-87-8

Cefadroxil monohydrate is a hydrated form of cefadroxil with similar action and applications as cefadroxil.

Formula: C₁₆H₁₇N₃O₅S•H₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 381.41 g/mol

Ref: 3D-AC19845

Cefadroxil Monohydrate (CFD), 95%

CAS: 66592-87-8

Formula: C₁₆H₁₇N₃O₅S·H₂O

Purity: min. 95%

Color and Shape: White to off - white, Crystalline powder

Molecular weight: 381.40

Ref: SR-15689

Cefadroxil monohydrate, Antibiotic for Culture Media Use Only

CAS: 66592-87-8

Cefadroxil is a broad-spectrum bactericidal antibiotic that belongs to the cephalosporin family. It is a semi-synthetic penicillin and inhibits bacterial cell wall synthesis through binding to one or more of the penicillin-binding proteins (PBPs). Cefadroxil monohydrate is used as an antibiotic for culture media and has been proven to be effective against methicillin-resistant Staphylococcus aureus (MRSA). In addition, the drug has been shown to have no significant effect on blood tests or microscopic studies.

Formula: C₁₆H₁₉N₃O₆S

Purity: Min. 97.0 Area-%

Molecular weight: 381.40 g/mol

Ref: 3D-Q-200807

Cefadroxil (hydrate)

CAS: 66592-87-8

Cefadroxil is a first generation aminocephalosporin with good patient compliance, a long-acting therapeutic effect, high solubility and relatively broad spectrum of anti-bacterial activity. Cefadroxil is also a substrate of the intestinal peptide transporter PepT1, which is primarily responsible for the drug's uptake across the apical membrane of small intestine.

Formula: C₁₆H₁₉N₃O₆S

Color and Shape: White Crystalline Solid

Molecular weight: 381.404

Ref: TM-T0366L